{"id":11408,"date":"2011-06-21T00:00:00","date_gmt":"2011-06-20T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/es\/blog\/2011\/06\/21\/joan-x-comella-cuanto-mas-musculadas-estan-nuestras-neuronas-mas-proteccion-tienen-en-un-entorno-hostil\/"},"modified":"2020-05-26T11:43:26","modified_gmt":"2020-05-26T09:43:26","slug":"joan-x-comella-cuanto-mas-musculadas-estan-nuestras-neuronas-mas-proteccion-tienen-en-un-entorno-hostil","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2011\/06\/joan-x-comella-cuanto-mas-musculadas-estan-nuestras-neuronas-mas-proteccion-tienen-en-un-entorno-hostil\/","title":{"rendered":"Joan X. Comella: \u201cCuanto m\u00e1s \u2018musculadas\u2019 est\u00e1n nuestras neuronas, m\u00e1s protecci\u00f3n tienen en un entorno hostil\u201d"},"content":{"rendered":"<p><strong>El grupo de investigaci\u00f3n de Joan X. Comella se centra en caracterizar y  conocer los mecanismos moleculares de determinadas prote\u00ednas que  bloquean la muerte celular en el sistema nervioso. Una muerte celular  frecuentemente relacionada con procesos inflamatorios. \u201cEstas prote\u00ednas  protegen a las neuronas de la muerte celular\u201d ha explicado Comella en  una conferencia enmarcada en el ciclo de seminarios del IDIBELL el  pasado 17 de junio.<\/strong> <strong><br \/><\/strong> \u201cQueremos caracterizar estas prote\u00ednas, saber cu\u00e1les son los mecanismos que regulan sus niveles en el sistema nervioso\u201d ha explicado Comella porque, aunque en las enfermedades neurodegenerativas influyen otros muchos factores, el estado de la neurona antes de recibir la agresi\u00f3n neuroinflamatoria tambi\u00e9n puede ser importante: \u201cCuanto m\u00e1s \u2018musculadas\u2019 est\u00e1n nuestras neuronas, es decir cuando tienen niveles elevados de estas prote\u00ednas, est\u00e1n m\u00e1s protegidas en un entorno hostil, como son las situaciones de neuroinflamaci\u00f3n\u201d. <b><br \/> En este sentido, el grupo de se\u00f1alizaci\u00f3n celular y apoptosis que Joan X. Comella lidera en el Instituto de Investigaci\u00f3n del Vall d\u2019Hebr\u00f3n (VHIR) est\u00e1 trabajando, con la colaboraci\u00f3n de la Universidad de Barcelona, para obtener un modelo de ratones transg\u00e9nicos que sobreexpresen estas prote\u00ednas protectoras para observar de qu\u00e9 manera este aumento de la protecci\u00f3n act\u00faa sobre enfermedades neuronales como el Alzheimer o la isquemia. \u201cEn enfermedades como el Alzheimer hemos visto que la disminuci\u00f3n en la expresi\u00f3n de estas prote\u00ednas se produce justo antes de que las neuronas empiecen a morir. Esto sugiere, aunque no est\u00e1 demostrado, que la ca\u00edda de los niveles de prote\u00edna hace que las neuronas no puedan resistir la agresi\u00f3n y mueran\u201d por eso dice Comella, \u201clas queremos sobreexpressar de forma artificial y ver si as\u00ed las neuronas sobreviven\u201d. Si fuera as\u00ed, las prote\u00ednas serian candidatas a ser una diana terap\u00e9utica para prevenir o tratar estas enfermedades.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>El grupo de investigaci\u00f3n de Joan X. Comella se centra en caracterizar y  conocer los mecanismos moleculares de determinadas prote\u00ednas que  bloquean la muerte celular en el sistema nervioso. Una muerte celular  frecuentemente relacionada con procesos inflamatorios. \u201cEstas prote\u00ednas  protegen a las neuronas de la muerte celular\u201d ha explicado Comella en  una conferencia enmarcada en el ciclo de seminarios del IDIBELL el  pasado 17 de junio.<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-11408","post","type-post","status-publish","format-standard","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2025-04-25 15:45:24","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11408","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=11408"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11408\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=11408"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=11408"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=11408"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}