{"id":11361,"date":"2012-01-31T00:00:00","date_gmt":"2012-01-30T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/es\/blog\/2012\/01\/31\/francesc-posas-la-investigacion-basica-permite-disenar-aplicaciones-clinicas-mucho-mas-precisas\/"},"modified":"2023-03-02T16:33:36","modified_gmt":"2023-03-02T15:33:36","slug":"francesc-posas-la-investigacion-basica-permite-disenar-aplicaciones-clinicas-mucho-mas-precisas","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2012\/01\/francesc-posas-la-investigacion-basica-permite-disenar-aplicaciones-clinicas-mucho-mas-precisas\/","title":{"rendered":"Francesc Posas: \u201cLa investigaci\u00f3n b\u00e1sica permite dise\u00f1ar aplicaciones cl\u00ednicas mucho m\u00e1s precisas\u201d"},"content":{"rendered":"<p>\u201cEntender como las c\u00e9lulas responden a situaciones de estr\u00e9s, como se dan cuenta de que existe una situaci\u00f3n peligrosa y los mecanismos que ponen en marcha para responder\u201d. Este es uno de los objetivos del laboratorio que dirige Francesc Posas en la <a href=\"http:\/\/www.upf.edu\/cexs\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"enllac\">Universidad Pompeu Fabra<\/span><\/a>. M\u00e1s concretamente, estudian las funciones de las quinasas en estos mecanismos de respuesta al estr\u00e9s. Lo ha explicado en el ciclo de seminarios IDIBELL el 27 de enero.<\/p>\n<p>El grupo de Posas trabaja con quinasas en c\u00e9lulas de levadura y de mam\u00edferos. La levadura es un modelo f\u00e1cilmente modificable, que permite trabajar muy r\u00e1pidamente e identificar mecanismos que despu\u00e9s trasladan a c\u00e9lulas de mam\u00edferos. \u201cEntender c\u00f3mo funcionan las quinasas para responder a situaciones de estr\u00e9s, nos permitir\u00e1 entender situaciones de enfermedad. Las quinasas regulan la progresi\u00f3n del ciclo celular, y la desregulaci\u00f3n de este ciclo es lo que puede crear problemas graves en el organismo\u201d.<\/p>\n<p>\u201cEn todo caso\u201d ha advertido Posas \u201chemos visto que las quinasas en c\u00e9lulas de mam\u00edferos, como la p38, adem\u00e1s de regular la respuesta a l estr\u00e9s cumplen otras funciones en procesos inflamatorios y otros. Esto es importante a la hora de buscar aplicaciones cl\u00ednicas\u201d. Seg\u00fan Posas, entender c\u00f3mo funcionan estas mol\u00e9culas y sus v\u00edas de se\u00f1alizaci\u00f3n nos permitir\u00e1n \u201cdiseccionar los procesos de la enfermedad y dise\u00f1ar aplicaciones cl\u00ednicas mucho m\u00e1s precisas, que inhibir directamente la quinasa, afectando a sus otras funciones\u201d.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u201cEntender como las c\u00e9lulas responden a situaciones de estr\u00e9s, como se dan cuenta de que existe una situaci\u00f3n peligrosa y los mecanismos que ponen en marcha para responder\u201d. Este es uno de los objetivos del laboratorio que dirige Francesc Posas en la Universidad Pompeu Fabra. M\u00e1s concretamente, estudian las funciones de las quinasas en estos [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":22239,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-11361","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2024-11-29 18:47:12","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11361","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=11361"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11361\/revisions"}],"predecessor-version":[{"id":22240,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11361\/revisions\/22240"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/22239"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=11361"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=11361"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=11361"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}