{"id":11350,"date":"2012-02-29T00:00:00","date_gmt":"2012-02-28T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/es\/blog\/2012\/02\/29\/luis-serrano-modificar-la-concentracion-de-una-proteina-un-cambio-epigenetico-puede-dar-como-resultado-una-enfermedad\/"},"modified":"2023-03-02T14:51:28","modified_gmt":"2023-03-02T13:51:28","slug":"luis-serrano-modificar-la-concentracion-de-una-proteina-un-cambio-epigenetico-puede-dar-como-resultado-una-enfermedad","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2012\/02\/luis-serrano-modificar-la-concentracion-de-una-proteina-un-cambio-epigenetico-puede-dar-como-resultado-una-enfermedad\/","title":{"rendered":"Luis Serrano: \u201cModificar la concentraci\u00f3n de una prote\u00edna, un cambio epigen\u00e9tico, puede dar como resultado una enfermedad\u201d"},"content":{"rendered":"<p>El director del <a href=\"http:\/\/pasteur.crg.es\/portal\/page\/portal\/Internet\/02_Research\/01_Programmes\/06_Systems_Biology\/01_Design_of_Biological_Systems\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"enllac\">Centro de Regulaci\u00f3n Gen\u00f3mica<\/span><\/a> (CRG) de Barcelona, Luis Serrano, explic\u00f3 los \u00faltimos avances de su grupo de investigaci\u00f3n en Biolog\u00eda de Sistemas en una conferencia del ciclo de seminarios IDIBELL el 24 de febrero.<\/p>\n<p>Uno de los puntos de inter\u00e9s del equipo de Serrano es estudiar las prote\u00ednas, no como mol\u00e9culas aisladas, sino como partes de un sistema que es m\u00e1s que la suma de sus componentes biol\u00f3gicos. \u201clas prote\u00ednas no est\u00e1n solas en la c\u00e9lula, siempre est\u00e1n ligadas a otras prote\u00ednas, formando diversos complejos&#8230; y la competencia entre estas prote\u00ednas para unirse a otras afecta a las v\u00edas de se\u00f1alizaci\u00f3n y puede derivar en alteraciones de la expresi\u00f3n g\u00e9nica\u201d.<\/p>\n<p>Por eso es por lo que una de las l\u00edneas de investigaci\u00f3n de Serrano es estudiar c\u00f3mo la concentraci\u00f3n de prote\u00ednas en la c\u00e9lula puede provocar enfermedades: \u201cHAsta hace unos a\u00f1os se pensaba que las enfermedades eran resultado de una mutaci\u00f3n gen\u00e9tica, ahora estamos demostrando que basta con variar la concentraci\u00f3n de una prote\u00edna, y esto es un cambio epigen\u00e9tico, para tener como resultado una enfermedad sin necesidad de ninguna mutaci\u00f3n inicial\u201d.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>El director del Centro de Regulaci\u00f3n Gen\u00f3mica (CRG) de Barcelona, Luis Serrano, explic\u00f3 los \u00faltimos avances de su grupo de investigaci\u00f3n en Biolog\u00eda de Sistemas en una conferencia del ciclo de seminarios IDIBELL el 24 de febrero. Uno de los puntos de inter\u00e9s del equipo de Serrano es estudiar las prote\u00ednas, no como mol\u00e9culas aisladas, [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":22201,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-11350","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2025-04-25 21:59:27","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11350","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=11350"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11350\/revisions"}],"predecessor-version":[{"id":22202,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11350\/revisions\/22202"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/22201"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=11350"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=11350"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=11350"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}