La revista Nature ha publicado en el primer n\u00famero de mayo un comentario del director del grupo de investigaci\u00f3n de Metabolismo y C\u00e1ncer del IDIBELL, George Thomas, y del investigador del mismo grupo Antonio Gentilella. Los investigadores hablan sobre dos estudios publicados en el mismo n\u00famero de la revista, sobre la prote\u00edna quinasa mTOR, un regulador clave para la s\u00edntesis de las prote\u00ednas. La quinasa mTOR regula la transici\u00f3n de varias prote\u00ednas que promueven la progresi\u00f3n del ciclo celular. Un funcionamiento an\u00f3malo de mTOR est\u00e1 relacionado con numerosas enfermedades, particularmente el c\u00e1ncer.<\/p>\n
Los dos trabajos comentados por los investigadores del IDIBELL se refieren a estudios realizados con una tecnolog\u00eda novedosa de traslaci\u00f3n activa de ARN mensajero, seguido de la inhibici\u00f3n de mTOR a trav\u00e9s de dos f\u00e1rmacos, que ha permitido obtener una nueva visi\u00f3n de la funci\u00f3n de esta prote\u00edna clave. En el art\u00edculo, titulado \u00abthe director ‘s cut\u00bb (la versi\u00f3n del director), Thomas y Gentilella destacan que los resultados de los estudios comentados \u00absugieren la existencia de un c\u00f3digo definido de mTOR que podr\u00eda modular los efectos de esta prote\u00edna seg\u00fan diferentes circunstancias celulares \u00ab.<\/p>\n
Los dos investigadores se han incorporado recientemente en el IDIBELL, procedentes del Instituto de Enfermedades Metab\u00f3licas de la Universidad de Cincinnati, y forman parte del nuevo grupo de Metabolismo y C\u00e1ncer en el centro de investigaci\u00f3n de Bellvitge.<\/p>\n
<\/p>\n
Referencia del art\u00edculo<\/strong><\/b><\/p>\n Gentilella A, Thomas G. Cancer biology: The director’s cut. Nature. 2012 May 2;485(7396):50-1. doi: 10.1038\/485050a.<\/p>\n","protected":false},"excerpt":{"rendered":" Referencia del art\u00edculo<\/p>\n","protected":false},"author":6,"featured_media":21318,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[184,251,281],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-19 06:00:09","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11320"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=11320"}],"version-history":[{"count":3,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11320\/revisions"}],"predecessor-version":[{"id":21320,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11320\/revisions\/21320"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/21318"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=11320"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=11320"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=11320"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}