C. elegans<\/em> sienta las bases para un modelo de estudio de respuesta de la quimioterapia en el contexto de un organismo vivo completo.<\/p>\nLas prote\u00ednas reguladoras 14-3-3, conservadas evolutivamente, se unen aprote\u00ednas de se\u00f1alizaci\u00f3n, afectando su estabilidad, actividad o localizaci\u00f3n celular. Por lo tanto, est\u00e1n involucradas en la regulaci\u00f3n de diversos procesos celulares, incluyendo la apoptosis, el ciclo celular y la respuesta al estr\u00e9s.<\/p>\n
Adem\u00e1s, los investigadores han encontrado que par-5 es necesario para la detenci\u00f3n del ciclo celular en respuesta al estr\u00e9s replicativo y las radiaciones ionizantes.<\/p>\n
Este estudio, que forma parte de la tesis de David Aristiz\u00e1bal, codirigida por el Dr. Cer\u00f3n y Dr. Scwhartz, fue financiado por el programa Marie Curie-IRG, y tambi\u00e9n, en parte, por el Centro de Investigaci\u00f3n de Redes de Bioingenier\u00eda, Biomateriales y Nanomedicina (CIBER-BBN).<\/p>\n
<\/p>\n
Referencia del art\u00edculo:<\/strong><\/p>\nThe 14-3-3 gene par-5 is required for germline development and DNA damage response in Caenorhabditis elegans. David Aristiz\u00e1bal-Corrales, Laura Fontrodona*, Montserrat Porta-de-la-Riva*, Angel Guerra-Moreno, Juli\u00e1n Cer\u00f3n<\/span>*(1) and Simo Schwartz<\/span>(1). J Cell Sci 2012 125:1716-1726
\n*Investigadores del IDIBELL (1) autores para correspondencia
\n<\/b><\/span><\/b><\/b><\/b><\/b><\/p>\n","protected":false},"excerpt":{"rendered":"Existen ciertas prote\u00ednas, como las 14-3-3, que conservan sus funciones b\u00e1sicas de control del ciclo celular en diversos organismos, que van desde gusanos hasta seres humanos. En un estudio dirigido por Juli\u00e1n Cer\u00f3n y Sim\u00f3 Schwartz Jr, investigadores del Instituto de Investigaci\u00f3n Biom\u00e9dica de Bellvitge (IDIBELL) y del Instituto de Investigaci\u00f3n Vall d’Hebron (VHIR) respectivamente, […]<\/p>\n","protected":false},"author":6,"featured_media":20887,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[186,298,297],"tags":[],"class_list":["post-11309","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-area-medicina-traslacional","category-modelos-de-enfermedad-en-c-elegans-programa-de-genes-enfermedad-y-terapia","category-programa-de-genes-enfermedad-y-terapia"],"publishpress_future_action":{"enabled":false,"date":"2024-09-15 02:16:26","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11309"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=11309"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11309\/revisions"}],"predecessor-version":[{"id":20888,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11309\/revisions\/20888"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/20887"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=11309"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=11309"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=11309"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}