Investigadores del IDIBELL y del ICO han participado en un estudio internacional sobre la transcripci\u00f3n de genes mediante fosforilaci\u00f3n de sustratos espec\u00edficos relacionado con la progresi\u00f3n del c\u00e1ncer y la met\u00e1stasis. Esta investigaci\u00f3n ha sido publicada esta semana en la revista cient\u00edfica Cell Reports.
\nEl estudio, liderado por investigadores del Instituto Municipal de Investigaciones M\u00e9dicas (IMIM) y, donde han participado los investigadores Alberto Villanueva y Mar\u00eda Mart\u00ednez, del grupo de investigaci\u00f3n de Quimiorresistencia y Factores Predictores de Respuesta Tumoral y Medio Ambiente Estromal del IDIBELL y del ICO, ha determinado la funci\u00f3n que tiene una nueva variante de la enzima IKKalpha (IKK\u03b1) en la activaci\u00f3n de algunos de los genes involucrados en la progresi\u00f3n tumoral del c\u00e1ncer colorrectal.<\/p>\n
El grupo de investigaci\u00f3n, con el fin de profundizar en el conocimiento de la mec\u00e1nica entre la g\u00e9nesis tumoral y la actividad de IKK\u03b1, analiz\u00f3 288 muestras humanas de c\u00e1ncer de colon y encontr\u00f3 una asociaci\u00f3n significativa entre la presencia de IKK nuclear y malignidad. Se demostr\u00f3 que la enzima IKK\u03b1 nuclear regula la transcripci\u00f3n de genes mediante la fosforilaci\u00f3n de sustratos espec\u00edficos, lo que se relaciona con la progresi\u00f3n del c\u00e1ncer y la met\u00e1stasis. Es importante destacar que el n\u00facleo de las c\u00e9lulas tumorales contiene una isoforma activa de IKK\u03b1 con un peso molecular de 45kDa, conocida como P45-IKK\u03b1. En la mayor\u00eda de muestras humanas de c\u00e1ncer de colon se identific\u00f3 la presencia de P45-IKK\u03b1. Se demostr\u00f3 que el bloqueo espec\u00edfico de esta nueva forma de IKK\u03b1 evita el crecimiento de las c\u00e9lulas de este tipo de c\u00e1ncer. Los resultados podr\u00edan significar un adelanto para el dise\u00f1o de nuevos f\u00e1rmacos para inhibir esta enzima de forma efectiva y ser menos t\u00f3xicos para el resto de c\u00e9lulas del organismo.<\/p>\n
<\/p>\n
<\/p>\n
Refencia del art\u00edculo<\/strong><\/p>\n A Truncated Form of IKK\u03b1 Is Responsible for Specific Nuclear IKK Activity in Colorectal Cancer. Pol Margalef, Vanessa Fern\u00e1ndez-Majada, Alberto Villanueva, Ricard Garcia-Carbonell, Mar Iglesias, Laura L\u00f3pez, Mar\u00eda Mart\u00ednez-Iniesta, Jordi Vill\u00e0-Freixa, Mari Carmen Mulero, Montserrat Andreu, Ferran Torres, Marty W. Mayo, Anna Bigas, Lluis Espinosa. Cell Reports 2, 1-15, October 25, 2012. Investigadores del IDIBELL y del ICO han participado en un estudio internacional sobre la transcripci\u00f3n de genes mediante fosforilaci\u00f3n de sustratos espec\u00edficos relacionado con la progresi\u00f3n del c\u00e1ncer y la met\u00e1stasis. Esta investigaci\u00f3n ha sido publicada esta semana en la revista cient\u00edfica Cell Reports. El estudio, liderado por investigadores del Instituto Municipal de Investigaciones M\u00e9dicas […]<\/p>\n","protected":false},"author":6,"featured_media":20296,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[184,371,281,206],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-09 13:37:08","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11266"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=11266"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11266\/revisions"}],"predecessor-version":[{"id":20297,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11266\/revisions\/20297"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/20296"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=11266"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=11266"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=11266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n<\/b><\/b><\/b><\/p>\n","protected":false},"excerpt":{"rendered":"