El oncog\u00e9n MED12 es b\u00e1sico en el control de respuesta a nuevos f\u00e1rmacos oncol\u00f3gicos, seg\u00fan un estudio publicado en Cell y realizado por investigadores del IDIBELL y del ICO en colaboraci\u00f3n con investigadores del Instituto Holand\u00e9s del C\u00e1ncer (NKI), en \u00c1msterdam.<\/p>\n
Esta investigaci\u00f3n, publicada en Cell, ha demostrado que el oncog\u00e9n MED12 tiene un papel clave en el control de la respuesta a diferentes f\u00e1rmacos oncol\u00f3gicos. Para desarrollar el estudio, los investigadores emplearon un modelo precl\u00ednico de pulm\u00f3n, con translocaci\u00f3n de ALK, muy sensible a crizotinib. Este f\u00e1rmaco es un inhibidor de ALK selectivo para la prote\u00edna de fusi\u00f3n generada al producirse dicha translocaci\u00f3n.<\/p>\n
La investigaci\u00f3n ha sido coordinada por el responsable cl\u00ednico y de investigaci\u00f3n de c\u00e1ncer de colon del ICO-Hospitalet e investigador del grupo de C\u00e1ncer Colorrectal del IDIBELL, Ram\u00f3n Salazar, que se plante\u00f3 c\u00f3mo identificar mecanismos de resistencia a critozinib. Para ello colabor\u00f3 con un grupo de investigaci\u00f3n de Ren\u00e9 Bernards, del Instituto Holand\u00e9s del C\u00e1ncer (NKI), experto en interpretar los mecanismos de resistencia para poder desarrollar hip\u00f3tesis y trasladarlas a ensayos cl\u00ednicos de combinaci\u00f3n de f\u00e1rmacos.<\/p>\n
En la investigaci\u00f3n se confirm\u00f3 un mecanismo de acci\u00f3n com\u00fan de resistencia a m\u00faltiples f\u00e1rmacos inhibidores de varias v\u00edas que acaban en ERK (quinasa regulada por se\u00f1al extracelular). En los experimentos de inmunoprecipitaci\u00f3n conjunta se confirm\u00f3 una acci\u00f3n postranscripcional a nivel prote\u00f3mico y en el citoplasma. De este modo, en cuanto se pone en contacto un modelo MED12KD aumenta la expresi\u00f3n del receptor de TGF-beta en la membrana al disminuir la coprecipitaci\u00f3n del citoplasma, una v\u00eda de resistencia muy conocida de m\u00faltiples receptores.<\/p>\n","protected":false},"excerpt":{"rendered":"
El oncog\u00e9n MED12 es b\u00e1sico en el control de respuesta a nuevos f\u00e1rmacos oncol\u00f3gicos, seg\u00fan un estudio publicado en Cell y realizado por investigadores del IDIBELL y del ICO en colaboraci\u00f3n con investigadores del Instituto Holand\u00e9s del C\u00e1ncer (NKI), en \u00c1msterdam. Esta investigaci\u00f3n, publicada en Cell, ha demostrado que el oncog\u00e9n MED12 tiene un papel […]<\/p>\n","protected":false},"author":6,"featured_media":20289,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[184,296,281],"tags":[],"class_list":["post-11264","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-area-cancer","category-cancer-colorectal-2","category-programa-de-mecanismos-moleculares-y-terapia-experimental-en-oncologia-oncobell"],"publishpress_future_action":{"enabled":false,"date":"2025-03-02 12:59:42","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11264","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=11264"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11264\/revisions"}],"predecessor-version":[{"id":20290,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11264\/revisions\/20290"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/20289"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=11264"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=11264"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=11264"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}