La conferencia \u00abBAF60c-MyoD complex poises chromatin for myogenic differentiation\u00bb de la Dra. S\u00f2nia Forcales, investigadora del Instituto de Medicina Predictiva y Personalizada del C\u00e1ncer (IMPPC), que tuvo lugar el pasado 22 de noviembre en la Sala de Actos de la Universidad de Barcelona (Campus Bellvitge) se centr\u00f3 en el papel de BAF60c en la diferenciaci\u00f3n muscular y la distrofia muscular.<\/p>\n
La Dra. Forcales se centr\u00f3 en las distrofias musculares (DMD). Hay m\u00e1s de 30 tipos de DMD y no existe una cura, s\u00f3lo tratamiento con finalidad paliativa. El proceso de degeneraci\u00f3n es insuficiente para hacer coincidir el ritmo de la degeneraci\u00f3n en la DMD. \u00abNosotros usamos un sistema in vitro<\/em> para estudiar un posible proceso de regeneraci\u00f3n. Quer\u00edamos comprender los cambios epigen\u00e9ticos que ocurren en la expresi\u00f3n g\u00e9nica para diferenciarse o multiplicarse. Existen tres BAF espec\u00edficas que codifican genes: a, b y c. Pero el BAF60c es el m\u00e1s abundante y tiene un papel esencial para la diferenciaci\u00f3n miog\u00e9nica\u00bb, dijo la investigadora.<\/p>\n \u00bfCu\u00e1l es el papel de BAF60c para el transcriptosoma miog\u00e9nico?<\/strong><\/p>\n La regulaci\u00f3n a la baja de BAF60c evita la uni\u00f3n de un transcriptosoma miog\u00e9nico activo. Tambi\u00e9n es importante para cualquier etapa del montaje. \u00abHay diferentes complejos en mioblastos y miotubos asociadas al BAF60c. Nuestros colaboradores en China encontraron que BAF60c preferentemente interact\u00faa con el MyoD homod\u00edmero. BAF60c y MyoD interact\u00faa en bioblastos \u00ab, dijo Forcales.<\/p>\n \u00abVimos que el complejo BAF60c-Myoden induce la reprogramaci\u00f3n de c\u00e9lulas madre para miosferas. El BAF60c es necesario para la diferenciaci\u00f3n muscular\u00bb, concluy\u00f3 la investigadora del IMPPC.<\/p>\n","protected":false},"excerpt":{"rendered":" La conferencia \u00abBAF60c-MyoD complex poises chromatin for myogenic differentiation\u00bb de la Dra. S\u00f2nia Forcales, investigadora del Instituto de Medicina Predictiva y Personalizada del C\u00e1ncer (IMPPC), que tuvo lugar el pasado 22 de noviembre en la Sala de Actos de la Universidad de Barcelona (Campus Bellvitge) se centr\u00f3 en el papel de BAF60c en la diferenciaci\u00f3n […]<\/p>\n","protected":false},"author":6,"featured_media":20038,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[184,395,281],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-14 19:13:36","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11226"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=11226"}],"version-history":[{"count":3,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11226\/revisions"}],"predecessor-version":[{"id":20039,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11226\/revisions\/20039"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/20038"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=11226"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=11226"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=11226"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}