{"id":11207,"date":"2013-02-05T00:00:00","date_gmt":"2013-02-04T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/es\/blog\/2013\/02\/05\/el-proyecto-europeo-coltheres-clasifica-el-cancer-colorectal-en-tres-subtipos\/"},"modified":"2022-02-23T12:56:03","modified_gmt":"2022-02-23T11:56:03","slug":"el-proyecto-europeo-coltheres-clasifica-el-cancer-colorectal-en-tres-subtipos","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2013\/02\/el-proyecto-europeo-coltheres-clasifica-el-cancer-colorectal-en-tres-subtipos\/","title":{"rendered":"El proyecto europeo COLTHERES clasifica el c\u00e1ncer colorectal en tres subtipos"},"content":{"rendered":"<p>Los investigadores del proyecto europeo <a href=\"http:\/\/www.coltheres.org\/2013\/02\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"enllac\">COLTHERES <\/span><\/a> han presentado en el Congreso de la <a class=\"enllac\" href=\"http:\/\/www.asco.org\/\" target=\"_blank\" rel=\"noopener noreferrer\">American Society of Clinical Oncology<\/a> Gastrointestinal Cancers, celebrado entre el 24 y el 26 de enero, los resultados preliminares del programa que tiene como objetivo fomentar los ensayos cl\u00ednicos de terapias personalizadas en c\u00e1ncer colorectal.<\/p>\n<p>Los investigadores han desarrollado un nuevo sistema de clasificaci\u00f3n que categoriza los tumores colorectales en tres subtipos completamente diferentes seg\u00fan su patr\u00f3n deexpresi\u00f3n gen\u00e9tica. El objetivo final es utilizar esta nueva clasificaci\u00f3n en la toma de decisiones terap\u00e9uticas.<\/p>\n<p>Josep Tabernero, director cl\u00ednico del <a href=\"http:\/\/www.vhio.net\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"enllac\">Instituto de Oncolog\u00eda del Vall d\u2019Hebr\u00f3n<\/span><\/a>, ha sido el encargado de presentar el estudio en el congreso de la ASCO GI. Tabernero ha explicado que esta categorizaci\u00f3n \u201cpodr\u00eda ser cl\u00ednicamente relevante, puesto que los tumores difieren en su biolog\u00eda y en su desarrollo en los pacientes y, por lo tanto requieren diferentes estrategias de tratamiento\u201d. Los pacientes con subtipos C son los de peor pron\u00f3stico y responden mal al tratamiento de quimioterapia con fluorouracilo, mientras que los subtipos A y B tienen mejores resultados.<\/p>\n<p><strong>\u00bfQu\u00e9 es COLTHERES?<\/strong><\/p>\n<p>En el proyecto COLTHERES participan hospitales y centros de investigaci\u00f3n traslacional de seis pa\u00edses europeos y su objetivo final es desarrollar terapias personalizadas en c\u00e1ncer de colon. El consorcio est\u00e1 integrado por unidades cl\u00ednicas pioneras en test de biomarcadores en terapias personalizadas y grupos de investigaci\u00f3n l\u00edderes en investigaci\u00f3n traslacional y con una trayectoria probada a la hora de desarrollar diagn\u00f3sticos para terapias contra el c\u00e1ncer.<\/p>\n<p>El Programa de Epigen\u00e9tica y Biolog\u00eda del C\u00e1ncer del IDIBELL, liderado por Manel Esteller, forma parte de este proyecto que cuenta con expertos internacionales en los campos de la gen\u00e9tica funcional, la epigen\u00f3mica, la farmacogen\u00e9tica y la oncolog\u00eda cl\u00ednica. La aportaci\u00f3n del IDIBELL es obtener perfiles epigen\u00f3micos de los pacientes y de los modelos experimentales para encontrar nuevos biomarcadores de pron\u00f3stico y de resistencia a f\u00e1rmacos en c\u00e1ncer colorectal.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Los investigadores del proyecto europeo COLTHERES han presentado en el Congreso de la American Society of Clinical Oncology Gastrointestinal Cancers, celebrado entre el 24 y el 26 de enero, los resultados preliminares del programa que tiene como objetivo fomentar los ensayos cl\u00ednicos de terapias personalizadas en c\u00e1ncer colorectal. Los investigadores han desarrollado un nuevo sistema [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":19864,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[286],"tags":[],"class_list":["post-11207","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-epigenetica-del-cancer-cancer"],"publishpress_future_action":{"enabled":false,"date":"2025-06-30 10:03:44","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11207","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=11207"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11207\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/19864"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=11207"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=11207"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=11207"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}