El campo de estudio de Piero Crespo del Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria (IBBTEC) es la regulaci\u00f3n de las se\u00f1ales Ras-ERK. El 19 de abril explic\u00f3 los \u00faltimos avances de su investigaci\u00f3n en una conferencia enmarcada en el ciclo de seminarios IDIBELL.<\/p>\n
Su trabajo se centra en el estudio de los mecanismos de regulaci\u00f3n de Ras en particular en c\u00f3mo la localizaci\u00f3n subcelular y el confinamiento de las se\u00f1ales inciden en las funciones biol\u00f3gicas y bioqu\u00edmicas de estas prote\u00ednas, tanto en contextos fisiol\u00f3gicos como patol\u00f3gicos.<\/p>\n
Seg\u00fan Piero Crespo \u201cla ruta de se\u00f1alizaci\u00f3n Ras-ERK est\u00e1 activada aproximadamente en el 50% de los tumores humanos.
\nNosotros estamos buscando nuevos tipos de f\u00e1rmacos para bloquear las se\u00f1ales que fluyen a trav\u00e9s de esta v\u00eda de se\u00f1alizaci\u00f3n\u201d.<\/p>\n
\u201cNos interesa encontrar dos tipos de inhibidores\u201d ha explicado Crespo \u201cpor un lado, que act\u00faen sitio-espec\u00edficamente bloqueando subse\u00f1ales en lugar de la se\u00f1al total, y por otro encontrar inhibidores que funcionen mediante el bloqueo prote\u00edna-prote\u00edna en vez de inhibir la actividad catab\u00f3lica de las prote\u00ednas involucradas en la ruta Ras-ERK\u201d.<\/p>\n","protected":false},"excerpt":{"rendered":"
El campo de estudio de Piero Crespo del Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria (IBBTEC) es la regulaci\u00f3n de las se\u00f1ales Ras-ERK. El 19 de abril explic\u00f3 los \u00faltimos avances de su investigaci\u00f3n en una conferencia enmarcada en el ciclo de seminarios IDIBELL. Su trabajo se centra en el estudio de los mecanismos de […]<\/p>\n","protected":false},"author":6,"featured_media":19620,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-11173","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2024-11-28 22:15:25","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11173","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=11173"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11173\/revisions"}],"predecessor-version":[{"id":19621,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11173\/revisions\/19621"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/19620"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=11173"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=11173"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=11173"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}