{"id":11157,"date":"2013-05-23T00:00:00","date_gmt":"2013-05-22T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/es\/blog\/2013\/05\/23\/desarrollan-un-modelo-de-radioterapia-que-permite-probar-en-ratones-nuevos-tratamientos-de-quimioterapia-contra-la-metastasis-cerebral\/"},"modified":"2021-12-01T17:33:59","modified_gmt":"2021-12-01T16:33:59","slug":"desarrollan-un-modelo-de-radioterapia-que-permite-probar-en-ratones-nuevos-tratamientos-de-quimioterapia-contra-la-metastasis-cerebral","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2013\/05\/desarrollan-un-modelo-de-radioterapia-que-permite-probar-en-ratones-nuevos-tratamientos-de-quimioterapia-contra-la-metastasis-cerebral\/","title":{"rendered":"Desarrollan un modelo de radioterapia que permite probar en ratones nuevos tratamientos de quimioterapia contra la met\u00e1stasis cerebral"},"content":{"rendered":"

Investigadores del IDIBELL han desarrollado un modelo terap\u00e9utico precl\u00ednico para probar nuevos tratamientos contra la met\u00e1stasis cerebral en pacientes de c\u00e1ncer de mama. Los resultados del estudio se han publicado en la revista International Journal of Molecular Sciences. En todo caso, la supervivencia en estas pacientes es de entre dos y diecis\u00e9is meses.<\/p>\n

Modelo precl\u00ednico de radioterapia<\/strong>
\nHasta ahora los modelos con ratones para tratar tumores con radioterapia implicaban irradiar todo el cuerpo del animal. La coordinadora del estudio, \u00c0ngels Sierra ha explicado que \u201ceste modelo limitaba mucho la supervivencia de los ratones y, adem\u00e1s, no se correspond\u00eda con el tratamiento que se usa en humanos\u201d. Los investigadores han ideado un modelo que, de forma precisa, permite irradiar el cerebro de ratones con la dosis adecuada sobre la zona del cerebro afectada por la met\u00e1stasis, de la manera m\u00e1s similar posible a como se hace en pacientes con c\u00e1ncer de mama que desarrollan met\u00e1stasis cerebral. \u201cEste nuevo modelo\u201d, ha dicho Sierra, \u201cnos permitir\u00e1 poder probar combinaciones de radio y quimioterapia experimental y saber si son candidatas a ser testadas en pacientes con un ensayo cl\u00ednico\u201d.<\/p>\n

Los investigadores del IDIBELL han probado una combinaci\u00f3n de radio y quimioterapia en qu\u00e9 los ratones control que no recib\u00edan ning\u00fan tratamiento y los que recib\u00edan s\u00f3lo radioterapia presentaban una supervivencia similar, mientras que los que hab\u00edan recibido la combinaci\u00f3n de radioterapia y un f\u00e1rmaco quimioterap\u00e9utico multiplicaban por cuatro su supervivencia.
\nSeg\u00fan ha explicado el primer firmante del art\u00edculo, Antonio Mart\u00ednez-Aranda, una de las bondades de este nuevo modelo es su reproducibilidad, es decir \u201cque otros grupos de investigaci\u00f3n podr\u00e1n utilizar este modelo precl\u00ednico para probar varias combinaciones de f\u00e1rmacos para tratar diferentes tipos de met\u00e1stasis\u201d.<\/p>\n

 <\/p>\n

Referencia del art\u00edculo<\/strong>
\nMart\u00ednez-Aranda A., Hern\u00e1ndez V., Pic\u00f3n C., Modolell I. And Sierra A. Development of a preclinical therapuetic model of human brain metastasis with chemoradiotherapy. Int. J. Mol. Sci.<\/em> 2013, 14<\/em>(4), 8306-8327; doi:10.3390\/ijms14048306<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Investigadores del IDIBELL han desarrollado un modelo terap\u00e9utico precl\u00ednico para probar nuevos tratamientos contra la met\u00e1stasis cerebral en pacientes de c\u00e1ncer de mama. Los resultados del estudio se han publicado en la revista International Journal of Molecular Sciences. En todo caso, la supervivencia en estas pacientes es de entre dos y diecis\u00e9is meses. Modelo precl\u00ednico […]<\/p>\n","protected":false},"author":6,"featured_media":19219,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[184,252,281,1],"tags":[275],"publishpress_future_action":{"enabled":false,"date":"2024-05-09 15:35:49","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11157"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=11157"}],"version-history":[{"count":3,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11157\/revisions"}],"predecessor-version":[{"id":19221,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11157\/revisions\/19221"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/19219"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=11157"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=11157"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=11157"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}