Investigadores del Instituto de Investigaci\u00f3n Biom\u00e9dica de Bellvitge (IDIBELL) liderados por el jefe del grupo de investigaci\u00f3n en sarcomas, Oscar Mart\u00ednez-Tirado, han descubierto uno de los mecanismos que desencadenan la angiog\u00e9nesis (formaci\u00f3n de nuevos vasos sangu\u00edneos) en torno a las c\u00e9lulas tumorales del Sarcoma de Ewing, un c\u00e1ncer infantil muy agresivo.<\/p>\n
La angiog\u00e9nesis es un proceso clave en el crecimiento, proliferaci\u00f3n y migraci\u00f3n de los tumores s\u00f3lidos. Las c\u00e9lulas tumorales necesitan nuevos vasos sangu\u00edneos que les aporten el ox\u00edgeno y los nutrientes extras que necesitan para desarrollarse a un ritmo tan r\u00e1pido.<\/p>\n
El grupo de Oscar Mart\u00ednez-Tirado ha descrito en varios estudios las funciones de la prote\u00edna caveolina-1 en Sarcoma de Ewing: \u00abHemos visto que tiene un papel tumorog\u00e9nico en este tipo de tumor, que participa en la resistencia a la quimioterapia, que favorece la met\u00e1stasis y en este trabajo hemos demostrado que juega un papel fundamental en el proceso angiog\u00e9nico\u00bb.<\/p>\n
Los investigadores comprobaron que, en l\u00edneas celulares modificadas gen\u00e9ticamente para no expresar la caveolina-1, los tumores eran m\u00e1s peque\u00f1os, presentaban m\u00e1s necrosis y el \u00edndice de vascularizaci\u00f3n era significativamente m\u00e1s bajo que en l\u00edneas con caveolina-1. \u00abPor lo tanto, la falta de caveolina-1 impide la angiog\u00e9nesis\u00bb ha afirmado Mart\u00ednez-Tirado. El investigador explic\u00f3 que aunque la caveolina-1 parece ser una posible diana terap\u00e9utica para combatir el sarcoma de Ewing, su localizaci\u00f3n, la hace de muy dif\u00edcil acceso \u201cas\u00ed que tenemos que buscar prote\u00ednas que se unen la caveolina-1 y puedan adoptar este papel\u00bb. En este sentido, el estudio describe c\u00f3mo la caveolina-1 interacciona con otra prote\u00edna llamada EphA2 activando una ruta de se\u00f1alizaci\u00f3n que induce la angiog\u00e9nesis, m\u00e1s concretamente la migraci\u00f3n de las c\u00e9lulas que deben formar los vasos hacia el tumor. Seg\u00fan explic\u00f3 Mart\u00ednez-Tirado \u00abesta prote\u00edna es un receptor de membrana que s\u00ed podr\u00eda ser un buen candidato para ser diana terap\u00e9utica\u00bb.<\/p>\n
Este hallazgo abre la puerta a futuras posibles terapias. \u00abAhora debemos estudiar si adem\u00e1s de estar implicada en la angiog\u00e9nesis, la prote\u00edna EphA2 es tumorog\u00e8nica per se<\/em>. Si lo es, estamos ante la diana perfecta. Nuestra idea de futuro es poder utilizar esta prote\u00edna como veh\u00edculo para liberar dentro de las c\u00e9lulas tumorales sustancias t\u00f3xicas\u201d explic\u00f3 Oscar Mart\u00ednez-Tirado.<\/p>\n En este trabajo tambi\u00e9n han participado investigadores del Hospital Vall d’Hebron, del Hospital Universitario de Salamanca y del Hospital San Joan de D\u00e9u de Barcelona.<\/p>\n Referencia del art\u00edculo<\/strong> Investigadores del Instituto de Investigaci\u00f3n Biom\u00e9dica de Bellvitge (IDIBELL) liderados por el jefe del grupo de investigaci\u00f3n en sarcomas, Oscar Mart\u00ednez-Tirado, han descubierto uno de los mecanismos que desencadenan la angiog\u00e9nesis (formaci\u00f3n de nuevos vasos sangu\u00edneos) en torno a las c\u00e9lulas tumorales del Sarcoma de Ewing, un c\u00e1ncer infantil muy agresivo. La angiog\u00e9nesis es un […]<\/p>\n","protected":false},"author":6,"featured_media":19062,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[184,281,241],"tags":[],"class_list":["post-11122","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-area-cancer","category-programa-de-mecanismos-moleculares-y-terapia-experimental-en-oncologia-oncobell","category-sarcoma"],"publishpress_future_action":{"enabled":false,"date":"2024-09-15 00:47:25","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11122"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=11122"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11122\/revisions"}],"predecessor-version":[{"id":19063,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11122\/revisions\/19063"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/19062"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=11122"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=11122"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=11122"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nS\u00e1inz-Jaspeado M., Huertas-Mart\u00ednez J., Lagares-Tena L., Liberal J.M., Mateo-Lozano S., de \u00c1lava E., de Torres C., Mora J., Garcia del Muro X. and Mart\u00ednez-Tirado O. EphA2-induced angiogenesis in Ewing sarcoma celles works through bGFG production and is dependent on caveolin-1. PLoS ONE. August 2013<\/p>\n","protected":false},"excerpt":{"rendered":"