{"id":11114,"date":"2013-09-27T00:00:00","date_gmt":"2013-09-26T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/es\/blog\/2013\/09\/27\/un-estudio-del-idibell-cuestiona-el-dogma-que-afirma-que-cuando-les-faltan-nutrientes-las-celulas-se-comen-a-si-mismas\/"},"modified":"2021-11-17T17:25:28","modified_gmt":"2021-11-17T16:25:28","slug":"un-estudio-del-idibell-cuestiona-el-dogma-que-afirma-que-cuando-les-faltan-nutrientes-las-celulas-se-comen-a-si-mismas","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2013\/09\/un-estudio-del-idibell-cuestiona-el-dogma-que-afirma-que-cuando-les-faltan-nutrientes-las-celulas-se-comen-a-si-mismas\/","title":{"rendered":"Un estudio del IDIBELL cuestiona el dogma que afirma que cuando les faltan nutrientes las c\u00e9lulas se comen a s\u00ed mismas"},"content":{"rendered":"<p>La autofagia es un mecanismo de protecci\u00f3n que utilizan las c\u00e9lulas en situaciones de estr\u00e9s. Degradan sus org\u00e1nulos y los reciclan para generar energ\u00eda y sobrevivir. Hasta ahora se cre\u00eda que en todas las situaciones de falta de nutrientes, las c\u00e9lulas iniciaban la autofagia. Un estudio del Instituto de Investigaci\u00f3n Biom\u00e9dica de Bellvitge (IDIBELL) liderado por Cristina Mu\u00f1oz-Pinedo cuestiona este dogma.<\/p>\n<p>\u00abHemos comprobado en diversas l\u00edneas celulares que la falta de glucosa no induce la autofagia\u201d ha explicado la investigadora. Los resultados del estudio se han publicado en la revista Journal of Biological Chemistry.<\/p>\n<p>\u201cLos inhibidores de la autofagia se est\u00e1n proponiendo como nuevos f\u00e1rmacos antitumorales, ya que se cree que la autofagia es un mecanismo de protecci\u00f3n de las c\u00e9lulas tumorales para poder seguir creciendo en ambientes pobres en nutrientes\u201d contin\u00faa Mu\u00f1oz-Pinedo \u201cy el hecho de que la privaci\u00f3n de glucosa, un nutriente esencial, no conduzca a la autofagia hace que debamos replantearnos el papel de este mecanismo como respuesta a la falta de nutrientes\u201d.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Referencia del art\u00edculo<\/strong><br \/>\nRam\u00edrez-Peinado S., Le\u00f3n-Annicchiarico C.L., Galindo-Moreno J., Caro-Maldonado A., Prehm J.H., Ryan K.M. and Mu\u00f1oz-Pinedo C. Glucose starved cells din not engage in pro-survival autophagy. The Journal of Biological Chemistry. 2013 sep 6. <a class=\"enllac\" href=\"http:\/\/www.jbc.org\/content\/early\/2013\/09\/06\/jbc.M113.490581.abstract\">http:\/\/www.jbc.org\/content\/early\/2013\/09\/06\/jbc.M113.490581.abstract<\/a><b><b><b><strong><b><br \/>\n<\/b><\/strong><\/b><\/b><\/b><\/p>\n","protected":false},"excerpt":{"rendered":"<p>La autofagia es un mecanismo de protecci\u00f3n que utilizan las c\u00e9lulas en situaciones de estr\u00e9s. Degradan sus org\u00e1nulos y los reciclan para generar energ\u00eda y sobrevivir. Hasta ahora se cre\u00eda que en todas las situaciones de falta de nutrientes, las c\u00e9lulas iniciaban la autofagia. Un estudio del Instituto de Investigaci\u00f3n Biom\u00e9dica de Bellvitge (IDIBELL) liderado [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":19032,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[184,245,281],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-15 17:21:37","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11114"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=11114"}],"version-history":[{"count":3,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11114\/revisions"}],"predecessor-version":[{"id":19033,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/11114\/revisions\/19033"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/19032"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=11114"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=11114"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=11114"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}