{"id":11103,"date":"2013-10-18T00:00:00","date_gmt":"2013-10-17T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/es\/blog\/2013\/10\/18\/alteraciones-en-la-funcion-de-la-proteina-dicer-generan-celulas-madre-y-promueven-la-metastasis-en-cancer-de-colon\/"},"modified":"2020-05-22T10:57:40","modified_gmt":"2020-05-22T08:57:40","slug":"alteraciones-en-la-funcion-de-la-proteina-dicer-generan-celulas-madre-y-promueven-la-metastasis-en-cancer-de-colon","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2013\/10\/alteraciones-en-la-funcion-de-la-proteina-dicer-generan-celulas-madre-y-promueven-la-metastasis-en-cancer-de-colon\/","title":{"rendered":"Alteraciones en la funci\u00f3n de la prote\u00edna DICER generan c\u00e9lulas madre y promueven la met\u00e1stasis en c\u00e1ncer de colon"},"content":{"rendered":"<p>Investigadores del grupo de Epigen\u00e9tica del C\u00e1ncer, liderado por Manel Esteller y del grupo de Envejecimiento y C\u00e1ncer, liderado por Purificaci\u00f3n Mu\u00f1oz, del Instituto de Investigaci\u00f3n Biom\u00e9dica de Bellvitge (IDIBELL), han demostrado que c\u00e9lulas de c\u00e1ncer de colon con una funci\u00f3n alterada de la prote\u00edna DICER, responsable del procesamiento y maduraci\u00f3n de microARNs, incrementa el contenido de c\u00e9lulas madre tumorales y potencia el desarrollo de met\u00e1stasis en h\u00edgado. <b><br \/> <strong>MicroARNs<\/strong> <b><br \/> Los microARNs (miARN) juegan un papel importante en las c\u00e9lulas, regulando la expresi\u00f3n de determinados genes. Estos miARNs son producidos como largas mol\u00e9culas de ARN, que, para ser funcionales, necesitan ser procesadas y maduradas por un complejo de prote\u00ednas del cual forma parte DICER. En estudios anteriores, se demostr\u00f3 que alteraciones en la producci\u00f3n y maduraci\u00f3n de determinados miARNs promueve el desarrollo de c\u00e1ncer. <b><br \/> En este art\u00edculo, publicado en la revista Oncogene, los investigadores demuestran que la p\u00e9rdida de funci\u00f3n de DICER conduce a un desequilibrio global en la producci\u00f3n de miARNSs y concretamente en aquellos que regulan la funci\u00f3n de las c\u00e9lulas madre tumorales y que controlan el proceso de transici\u00f3n epitelio-mes\u00e9nquima, proceso asociado con la migraci\u00f3n de c\u00e9lulas tumorales. En consecuencia, las c\u00e9lulas tumorales con una funci\u00f3n deficiente en DICER presentan una mayor capacidad para generar tumores e inducir el desarrollo de met\u00e1stasis. <b><br \/> <strong>Las c\u00e9lulas madre tumorales controlan el crecimiento tumoral y el desarrollo de met\u00e1stasis<\/strong> <b><br \/> En la mayor\u00eda de los tumores hay c\u00e9lulas que muestran propiedades similares a las c\u00e9lulas madre adultas que hay en todos los tejidos. A esta poblaci\u00f3n de c\u00e9lulas se les llama c\u00e9lulas madre tumorales y se considera que son responsables del crecimiento tumoral y de la generaci\u00f3n de met\u00e1stasis. Estas c\u00e9lulas pierden caracter\u00edsticas de c\u00e9lulas epiteliales, asociadas al proceso de transici\u00f3n epitelio-mes\u00e9nquima y ser\u00edan las c\u00e9lulas responsables de iniciar el crecimiento de la met\u00e1stasis tras su migraci\u00f3n desde el tumor primario. <b><br \/> En este art\u00edculo se demuestra que la prote\u00edna DICER regula propiedades de las c\u00e9lulas madre de tumores de colon y que alteraciones en su funci\u00f3n tienen importantes consecuencias, promoviendo la progresi\u00f3n tumoral. <b><br \/> <strong>Referencia del art\u00edculo<\/strong> <b><br \/> <b><br \/>V, Carmona FJ, Ramalho-Carvalho J, Heyn H, Villanueva A, Mu\u00f1oz P and Esteller M. <strong>Impaired DICER1 function promotes stemness and metastasis in colon cancer<\/strong>. <em>Oncogene,<\/em> doi: 10.1038\/onc.2013.398, 2013.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>MicroARNs Las c\u00e9lulas madre tumorales controlan el crecimiento tumoral y el desarrollo de met\u00e1stasis Referencia del art\u00edculo Impaired DICER1 function promotes stemness and metastasis in colon cancer<\/p>\n","protected":false},"author":6,"featured_media":11104,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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