Un estudio internacional liderado por el investigador Miguel \u00c1ngel Pujana del Instituto de Investigaci\u00f3n Biom\u00e9dica de Bellvitge (IDIBELL) y del Instituto Catal\u00e1n de Oncolog\u00eda (ICO) describe un nuevo m\u00e9todo que podr\u00eda permitir la identificaci\u00f3n de interacciones gen\u00e9ticas asociadas con el riesgo de sufrir c\u00e1ncer.
Los estudios de asociaciones gen\u00e9ticas a nivel gen\u00f3mico global (ie GWAS) han permitido identificar docenas de variantes gen\u00e9ticas comunes asociadas al riesgo de padecer c\u00e1ncer en la poblaci\u00f3n general. Sin embargo, estas variantes explican s\u00f3lo una peque\u00f1a fracci\u00f3n de la heredabilidad de la enfermedad. La otra fracci\u00f3n se atribuye a otros factores, entre los cuales encontrar\u00edamos las interacciones gen\u00e9ticas. En este tipo de interacciones, el efecto combinado de dos alelos\/ mutaciones\/ genes es diferente del de cada uno de ellos por separado.
En el estudio que ha publicado la edici\u00f3n electr\u00f3nica de la revista Carcinogenesis se describe c\u00f3mo a trav\u00e9s de la integraci\u00f3n de informaci\u00f3n gen\u00e9tica obtenida por GWAS con datos de expresi\u00f3n g\u00e9nica en tumores se pueden identificar interacciones gen\u00e9ticas asociadas al riesgo de padecer c\u00e1ncer. El m\u00e9todo se ha utilizado en c\u00e1ncer de mama y de p\u00e1ncreas, y puede ser extensible a diferentes tipos de neoplasias incrementando as\u00ed el conocimiento sobre la heredabilidad de la enfermedad. <\/p>\n","protected":false},"excerpt":{"rendered":"
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