{"id":10999,"date":"2014-04-09T00:00:00","date_gmt":"2014-04-08T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/es\/blog\/2014\/04\/09\/investigadores-del-idibell-describen-un-nuevo-gen-supresor-tumoral-en-el-higado\/"},"modified":"2020-05-22T09:03:12","modified_gmt":"2020-05-22T07:03:12","slug":"investigadores-del-idibell-describen-un-nuevo-gen-supresor-tumoral-en-el-higado","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2014\/04\/investigadores-del-idibell-describen-un-nuevo-gen-supresor-tumoral-en-el-higado\/","title":{"rendered":"Investigadores del IDIBELL describen un nuevo gen supresor tumoral en el h\u00edgado"},"content":{"rendered":"<p>Un estudio del Instituto de Investigaci\u00f3n Biom\u00e9dica de Bellvitge (IDIBELL) demuestra que la inhibici\u00f3n de NOX4 en c\u00e9lulas tumorales hep\u00e1ticas aumenta su capacidad proliferativa y por tanto su capacidad tumorog\u00e9nica. <b><br \/> El laboratorio de Claves Biol\u00f3gicas del Fenotipo Invasivo y Met\u00e1statico dirigido por Isabel Fabregat estudia las funciones de las NADPH oxidasas (NOX) en la fisiopatolog\u00eda del h\u00edgado. Las NOX forman una familia de enzimas capaces de producir estr\u00e9s oxidativo, que median un gran n\u00famero de procesos celulares. <b><br \/> El estudio,<b><br \/> que publica la revista Free Radical Biology and Medicine, describe el efecto supresor de tumores de una de estas NADPH oxidasas llamada NOX4. <b><br \/> \u201cHemos comprobado que si inhibimos NOX4 aumentan las capacidades proliferativa y tumorog\u00e9nica de distintas l\u00edneas celulares de hepatocarcinoma por lo que proponemos que NOX4 puede ser un supresor tumoral en el h\u00edgado\u201d ha explicado Fabregat. <b><br \/> El trabajo tambi\u00e9n ha comprobado que las c\u00e9lulas tumorales hep\u00e1ticas presentan una expresi\u00f3n menor de NOX4 que las c\u00e9lulas normales. <b><br \/> Actualmente existe un inter\u00e9s por encontrar f\u00e1rmacos inhibidores de NOX4 ya que se ha descrito que esta enzima est\u00e1 implicada en fibrosis hep\u00e1tica. Fabregat afirma que \u201ceste estudio profundiza en los efectos que la inhibici\u00f3n del NOX4 puede tener en la fisiopatolog\u00eda del h\u00edgado\u201d. <b><br \/> Crosas-Molist E., Bertran E., Sancho P., L\u00f3pez-Luque J., Fernando J., S\u00e1nchez A., Fern\u00e1ndez M, Navarro E. and Fabregat I. <strong>The NADPH oxidase NOX4 inhibits hepatocyte proliferation and liver cancer progression<\/strong>. Free Radical Biology and Medicine. <a title=\"Go to table of contents for this volume\/issue\" href=\"http:\/\/www.sciencedirect.com\/science\/journal\/08915849\/69\/supp\/C\">Volume 69<\/a>, April 2014, Pages 338\u2013347<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La enzima NOX4 inhibe el crecimiento de las c\u00e9lulas tumorales hep\u00e1ticas Referencia del art\u00edculo  The NADPH oxidase NOX4 inhibits hepatocyte proliferation and liver cancer progression<\/p>\n","protected":false},"author":6,"featured_media":11000,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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