{"id":10942,"date":"2014-07-24T00:00:00","date_gmt":"2014-07-23T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/es\/blog\/2014\/07\/24\/nuevas-regiones-del-material-genetico-implicadas-en-el-desarrollo-de-cancer-de-colon\/"},"modified":"2020-05-22T08:32:58","modified_gmt":"2020-05-22T06:32:58","slug":"nuevas-regiones-del-material-genetico-implicadas-en-el-desarrollo-de-cancer-de-colon","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2014\/07\/nuevas-regiones-del-material-genetico-implicadas-en-el-desarrollo-de-cancer-de-colon\/","title":{"rendered":"Nuevas regiones del material gen\u00e9tico implicadas en el desarrollo de c\u00e1ncer de colon"},"content":{"rendered":"<p>La mayor parte de las investigaciones sobre los genes en c\u00e1ncer humano, se han centrado en las en las regiones del genoma llamadas codificantes (exones) que son las que se traducen en forma de amino\u00e1cidos y por tanto de prote\u00ednas. Pero justo antes de cada gen, existe una regi\u00f3n reguladora o activadora que controla la expresi\u00f3n y actividad del gen colindante. Hasta ahora, se conoc\u00eda muy poco del papel que ejerc\u00edan dichos fragmento del ADN en el desarrollo de tumores. <b><br \/> Un art\u00edculo publicado hoy en <strong><em>Nature<\/em><\/strong><em> <\/em>con la colaboraci\u00f3n del grupo de Manel Esteller, Director del Programa de Epigen\u00e9tica y Biolog\u00eda del C\u00e1ncer del Instituto de Investigaciones Biom\u00e9dicas de Bellvitge (IDIBELL), Investigador ICREA y Profesor de Gen\u00e9tica de la Universidad de Barcelona, \u200b\u200b demuestra que estas regiones se encuentran tambi\u00e9n alteradas en c\u00e1ncer. <b><br \/> \u00abLos resultados del estudio de <strong><em>Nature <\/em><\/strong>revelan que las regiones reguladoras que preceden al gen como tal, son variables, pueden mutar y modificarse qu\u00edmicamente, como por ejemplo con la metilaci\u00f3n del ADN, en las c\u00e9lulas de la transformaci\u00f3n tumoral\u201d declara Manel Esteller, co-autor del estudio. <b><br \/> \u00abEstudiando una extensa cohorte de pacientes de c\u00e1ncer de colon, un tipo de tumor muy frecuente en nuestra sociedad, nos dimos cuenta de que \u00e9stas zonas de control de los genes estaban tan lesionadas como los genes y causaban una funci\u00f3n alterada del gen diana. Adem\u00e1s el trabajo muestra una nueva lista de genes implicados en la aparici\u00f3n del c\u00e1ncer, desconocidos hasta ahora, que son aberrantes simplemente por un mal control de estas regiones promotoras\u201d. <b><br \/> Estos descubrimientos pueden tener una importancia profunda en la comprensi\u00f3n de la biolog\u00eda del c\u00e1ncer ya que subrayan la necesidad no s\u00f3lo de centrarse en la regi\u00f3n de los genes m\u00e1s cl\u00e1sica (exoma), sino tambi\u00e9n interrogarnos sobre las regiones reguladoras de oncogenes y genes supresores de tumores. <b><br \/> <b><br \/> Ongen H, Andersen CL, Bramsen JB, Oster B, Rasmussen MH, Ferreira PG, Sandoval J, Vidal E, Whiffin N, Planchon A, Padioleau I, Bielser D, Romano L, Tomlinson I, Houlston RS, Esteller M, Orntoft TF, Dermitzakis ET. Putative cis-regulatory drivers in colorectal cancer. <strong><em><span style=\"text-decoration: underline\">Nature<\/span><\/em><\/strong>, DOI: 10.1038\/nature13602, 2014<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nature Nature Referencia del art\u00edculo Referencia del art\u00edculo Nature<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[184,286],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-10 14:15:30","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10942"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=10942"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10942\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=10942"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=10942"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=10942"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}