La transcripci\u00f3n es uno de los mecanismos que ocurren en las c\u00e9lulas y que permite leer la informaci\u00f3n contenida en los genes. Un estudio encabezado por la Unidad de Biomarcadores y Susceptibilidad del Programa de Prevenci\u00f3n y Control del C\u00e1ncer del ICO-IDIBELL ha detectado grandes diferencias en los programas de regulaci\u00f3n transcripcional de las c\u00e9lulas normales y las c\u00e9lulas de tumores de colon.
En el estudio, que se ha publicado en la revista BMC Cancer, los investigadores han comparado los perfiles de expresi\u00f3n g\u00e9nica de un centenar de muestras de tumores de colon con el de sus cien parejas de tejido normal adyacente y han detectado diferencias en la actividad transcripcional y la interacci\u00f3n entre los propios genes. Se concluye con un mensaje de p\u00e9rdida global de la actividad transcripcional en las c\u00e9lulas tumorales de colon. Pero por otro lado, por ejemplo, se describen unos pocos factores de transcripci\u00f3n que aumentan considerablemente su actividad en las c\u00e9lulas tumorales respecto a las normales.
El estudio abre la puerta a una mejor compresi\u00f3n de las alteraciones en los programas que regulan la transcripci\u00f3n de las c\u00e9lulas tumorales de colon.
Cordero D, Sol\u00e9 X, Crous-Bou M, Sanz-Pamplona R, Par\u00e9-Brunet L, Guin\u00f3 E, Olivares D, Berenguer A, Santos C, Salazar R, Biondo S, Moreno V. Large differences in global transcriptional regulatory programs of normal and tumor colon cells.. BMC Cancer. 2014 Sep 24;14:708. doi: 10.1186\/1471-2407-14-708 <\/p>\n","protected":false},"excerpt":{"rendered":"
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