{"id":10881,"date":"2014-12-12T00:00:00","date_gmt":"2014-12-11T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/es\/blog\/2014\/12\/12\/la-manipulacion-de-pequenos-arns-endogenos-permite-recuperar-una-infertilidad-transgeneracional-progresiva-en-c-elegans\/"},"modified":"2020-05-21T09:12:45","modified_gmt":"2020-05-21T07:12:45","slug":"la-manipulacion-de-pequenos-arns-endogenos-permite-recuperar-una-infertilidad-transgeneracional-progresiva-en-c-elegans","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2014\/12\/la-manipulacion-de-pequenos-arns-endogenos-permite-recuperar-una-infertilidad-transgeneracional-progresiva-en-c-elegans\/","title":{"rendered":"La manipulaci\u00f3n de peque\u00f1os ARNs end\u00f3genos permite recuperar una infertilidad transgeneracional progresiva en C.elegans"},"content":{"rendered":"<p>Cada d\u00eda se sabe m\u00e1s sobre la estructura de los genomas y su influencia en la regulaci\u00f3n de la expresi\u00f3n de los genes. En la investigaci\u00f3n de los componentes de los genomas, el modelo de nematodo <em>C.elegans<\/em> es pionero ya que su genoma fue el primero de un organismo multicelular en ser secuenciado. <b><br \/> El estudio publicado por la revista Cell Reports, es el resultado de la colaboraci\u00f3n del equipo de Juli\u00e1n Cer\u00f3n en el grupo de quimiorresistencia y factores predictores de respuesta tumoral y medio ambiente estromal del IDIBELL con los grupos de Ben Lehner y Juan Valc\u00e1rcel del Centro de Regulaci\u00f3n Gen\u00f3mica (CRG). Los investigadores han descrito la influencia de genes antisentido y de peque\u00f1os ARN de interferencia end\u00f3genos (siRNAs) en la regulaci\u00f3n del gen TOR, un gen altamente conservado en eucariotas que regula el crecimiento y el metabolismo de organismos en respuesta a nutrientes. <b><br \/> Los autores del estudio han demostrado que este mecanismo influye en la fertilidad del animal. \u00abSi manipulamos la expresi\u00f3n de TOR y el balance de sus isoformas\u00bb explic\u00f3 Cer\u00f3n \u00absomos capaces de revertir la infertilidad que se transmite epigen\u00e9ticamente entre generaciones de animales mutados\u00bb. <b><br \/> Co-option of the Pirna Pathway for Germline-Specific Alternative Splicing of C. elegans TOR. Barber\u00e1n-Soler S, Fontrodona L, Rib\u00f3 A, Lamm AT, Iannone C, Cer\u00f3n J, Lehner B, Valc\u00e1rcel J. Cell Reports. 2014 Sep 10. PII: S2211-1247 (14) 00679-2.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Referencia del art\u00edculo<\/p>\n","protected":false},"author":6,"featured_media":10882,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[186,298,297],"tags":[275],"class_list":["post-10881","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-area-medicina-traslacional","category-modelos-de-enfermedad-en-c-elegans-programa-de-genes-enfermedad-y-terapia","category-programa-de-genes-enfermedad-y-terapia","tag-medicina-traslacional"],"publishpress_future_action":{"enabled":false,"date":"2024-11-29 23:36:16","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10881","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=10881"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10881\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/10882"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=10881"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=10881"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=10881"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}