{"id":10881,"date":"2014-12-12T00:00:00","date_gmt":"2014-12-11T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/es\/blog\/2014\/12\/12\/la-manipulacion-de-pequenos-arns-endogenos-permite-recuperar-una-infertilidad-transgeneracional-progresiva-en-c-elegans\/"},"modified":"2020-05-21T09:12:45","modified_gmt":"2020-05-21T07:12:45","slug":"la-manipulacion-de-pequenos-arns-endogenos-permite-recuperar-una-infertilidad-transgeneracional-progresiva-en-c-elegans","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2014\/12\/la-manipulacion-de-pequenos-arns-endogenos-permite-recuperar-una-infertilidad-transgeneracional-progresiva-en-c-elegans\/","title":{"rendered":"La manipulaci\u00f3n de peque\u00f1os ARNs end\u00f3genos permite recuperar una infertilidad transgeneracional progresiva en C.elegans"},"content":{"rendered":"

Cada d\u00eda se sabe m\u00e1s sobre la estructura de los genomas y su influencia en la regulaci\u00f3n de la expresi\u00f3n de los genes. En la investigaci\u00f3n de los componentes de los genomas, el modelo de nematodo C.elegans<\/em> es pionero ya que su genoma fue el primero de un organismo multicelular en ser secuenciado.
El estudio publicado por la revista Cell Reports, es el resultado de la colaboraci\u00f3n del equipo de Juli\u00e1n Cer\u00f3n en el grupo de quimiorresistencia y factores predictores de respuesta tumoral y medio ambiente estromal del IDIBELL con los grupos de Ben Lehner y Juan Valc\u00e1rcel del Centro de Regulaci\u00f3n Gen\u00f3mica (CRG). Los investigadores han descrito la influencia de genes antisentido y de peque\u00f1os ARN de interferencia end\u00f3genos (siRNAs) en la regulaci\u00f3n del gen TOR, un gen altamente conservado en eucariotas que regula el crecimiento y el metabolismo de organismos en respuesta a nutrientes.
Los autores del estudio han demostrado que este mecanismo influye en la fertilidad del animal. \u00abSi manipulamos la expresi\u00f3n de TOR y el balance de sus isoformas\u00bb explic\u00f3 Cer\u00f3n \u00absomos capaces de revertir la infertilidad que se transmite epigen\u00e9ticamente entre generaciones de animales mutados\u00bb.
Co-option of the Pirna Pathway for Germline-Specific Alternative Splicing of C. elegans TOR. Barber\u00e1n-Soler S, Fontrodona L, Rib\u00f3 A, Lamm AT, Iannone C, Cer\u00f3n J, Lehner B, Valc\u00e1rcel J. Cell Reports. 2014 Sep 10. PII: S2211-1247 (14) 00679-2.<\/p>\n","protected":false},"excerpt":{"rendered":"

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