La t\u00e9cnica se basa en el uso de modelos ortot\u00f3picos (orthoxenograft\u00ae) de rat\u00f3n, mediante la implantaci\u00f3n de tumores humanos en el \u00f3rgano correspondiente del rat\u00f3n. As\u00ed, por ejemplo, cuando se hace una biopsia al paciente o se le extrae el tumor, se pueden implantar las c\u00e9lulas cancer\u00edgenas al mismo \u00f3rgano al rat\u00f3n.
De esta manera, el modelo animal reproduce las caracter\u00edsticas histol\u00f3gicas, gen\u00e9ticas y epigen\u00e9ticas de los tumores humanos, as\u00ed como los patrones de diseminaci\u00f3n del tumor, lo que no se consigue con otros m\u00e9todos de implantaci\u00f3n.
Por su parte, se puede aplicar el mismo tratamiento que recibe el paciente en el rat\u00f3n, y seguir su evoluci\u00f3n, lo que abre la puerta a valorar el riesgo de sufrir reca\u00eddas as\u00ed como el tratamiento m\u00e1s eficaz y con menos efectos secundarios en cada caso, consiguiendo una terapia personalizada, ya que cada paciente tendr\u00eda su modelo animal correspondiente.
El equipo del ICO-IDIBELL, en cola \u2022 raci\u00f3n con el CNIO de Madrid, y el Boston Childrens Hospital ha logrado con \u00e9xito obtener modelos en c\u00e1ncer de colon, pulm\u00f3n y ovario.<\/p>\n","protected":false},"excerpt":{"rendered":"
La implantaci\u00f3n de c\u00e9lulas cancer\u00edgenas del paciente en el mismo \u00f3rgano de ratones permite reproducir con mucha precisi\u00f3n la evoluci\u00f3n y malignidad del tumor Modelos ortot\u00f3picos<\/p>\n","protected":false},"author":6,"featured_media":10872,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[184],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-12 14:04:52","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10871"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=10871"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10871\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/10872"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=10871"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=10871"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=10871"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}