{"id":10755,"date":"2015-06-18T00:00:00","date_gmt":"2015-06-17T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/es\/blog\/2015\/06\/18\/hallan-una-diana-potencial-para-el-tratamiento-de-la-diabetes-tipo-2\/"},"modified":"2020-05-20T16:11:35","modified_gmt":"2020-05-20T14:11:35","slug":"hallan-una-diana-potencial-para-el-tratamiento-de-la-diabetes-tipo-2","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2015\/06\/hallan-una-diana-potencial-para-el-tratamiento-de-la-diabetes-tipo-2\/","title":{"rendered":"Hallan una diana potencial para el tratamiento de la diabetes tipo 2"},"content":{"rendered":"<p><b><br \/> Actualmente, hay m\u00e1s de 350 millones de diab\u00e9ticos tipo 2 y de acuerdo con la Organizaci\u00f3n Mundial de la Salud (OMS) para el a\u00f1o 2030 ser\u00e1 la s\u00e9ptima causa de muerte en todo el mundo. <b><br \/> La marca m\u00e1s caracter\u00edstica de la diabetes mellitus tipo 2 es la resistencia a la insulina que se ve inicialmente compensada por un aumento del tama\u00f1o de las c\u00e9lulas beta pancre\u00e1ticas, (encargadas de producir la insulina) hasta que \u00e9stas se colapsan y mueren y es cuando la enfermedad entra en un estado avanzado. <b><br \/> Investigadores del Laboratorio de Metabolismo y C\u00e1ncer del IDIBELL liderados por Sara Kozma han demostrado en modelos animales que la inhibici\u00f3n de la prote\u00edna S6K1 puede ser un potencial tratamiento para la diabetes tipo 2. <b><br \/> En un estudio publicado esta semana en la revista Journal Clinic of Investigation los investigadores han demostrado que los animales que no tienen S6K1, una prote\u00edna quinasa, son m\u00e1s sensibles a la insulina, por lo tanto necesitan menos y no desarrollan la diabetes. <b><br \/> <b><br \/> En estudios anteriores el grupo de Kozma hab\u00eda observado que los ratones deficientes en S6K1 eran m\u00e1s peque\u00f1os y que presentaban unos niveles circulantes de insulina por debajo de lo normal. \u00abDemostramos que las c\u00e9lulas beta de estos animales eran m\u00e1s peque\u00f1as y produc\u00edan menos insulina\u00bb explica la investigadora. \u00abTambi\u00e9n demostraron que en ausencia de S6K1, los tejidos perif\u00e9ricos del animal se hac\u00edan m\u00e1s sensibles a la insulina y no desarrollaban la enfermedad, incluso cuando se les somet\u00eda a una dieta rica en grasas\u00bb. <b><br \/> En este estudio, el grupo de Kozma ha utilizado la t\u00e9cnica de rescate embrionario para entender por qu\u00e9 las c\u00e9lulas beta de estos ratones eran m\u00e1s peque\u00f1as. Implantaron c\u00e9lulas madre embrionarias deficientes en S6K1 en placentas de ratones normales y vieron que aunque el embri\u00f3n alcanzaba un tama\u00f1o normal, sus c\u00e9lulas beta segu\u00edan siendo peque\u00f1as. Por lo tanto, el tama\u00f1o de las c\u00e9lulas beta es independiente del desarrollo del rat\u00f3n en el \u00fatero y es la ausencia de S6K1 los tejidos perif\u00e9ricos la que permite el aumento de la sensibilidad a la insulina del animal. De forma que, los inhibidores de esta prote\u00edna pueden servir como potenciales sensibilizadores a la insulina para proteger contra su insensibilidad y tratar la diabetes tipo 2. <b><br \/> <strong>Referencia del art\u00edculo<\/strong> <b><br \/> Sung Hee Um, Melanie Sticker-Jantscheff, Chau Gia Cac, Kristina Vintersten, Matthias Mueller, Yann-Gael Gangloff, Ralf H. Adams, Jean-Francois Spetz, Lynda Elghazi, T. Paul Pflug, Mario Pende, Ernesto Bernal-MIZRACHI, Albert Tauler, Matthias H. Tsch\u00f6p, George Thomas and Sara C. Kozma. S6K1 controls pancreatic \u03b2 cell Independently of size intrauterine growth restriction. Journal of Clinical<b><br \/>Investigation. 2015 doi: 10.1172 \/ JCI77030<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La inhibici\u00f3n de la prote\u00edna S6K1 hace a los animales m\u00e1s sensibles a la insulina. \u00bfPodr\u00eda tratarse de una posible diana terap\u00e9utica para la diabetes tipo 2? Ratones m\u00e1s peque\u00f1os y con menos insulina Referencia del art\u00edculo<\/p>\n","protected":false},"author":6,"featured_media":10756,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[184,251,281],"tags":[],"class_list":["post-10755","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-area-cancer","category-metabolismo-y-cancer","category-programa-de-mecanismos-moleculares-y-terapia-experimental-en-oncologia-oncobell"],"publishpress_future_action":{"enabled":false,"date":"2024-12-30 01:45:47","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10755","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=10755"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10755\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/10756"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=10755"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=10755"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=10755"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}