El c\u00e1ncer de mama es una enfermedad heterog\u00e9nea que abarca una gran variedad de subtipos, que son cl\u00ednica, morfol\u00f3gica y molecularmente diferentes. Es el tumor m\u00e1s frecuente en mujeres y a pesar de los avances actuales en su diagn\u00f3stico precoz y tratamiento, sigue siendo la principal causa de muerte en las mujeres con c\u00e1ncer.
El 15% de los casos recientemente diagnosticados son c\u00e1nceres de mama triple negativo, que se definen por su falta de expresi\u00f3n de receptores (receptor de estr\u00f3geno (ER), receptor de progesterona (PGR) y factor de crecimiento epid\u00e9rmico humano 2 (HER2). Hoy en d\u00eda el c\u00e1ncer de mama triple negativo es probablemente una de las \u00e1reas m\u00e1s activas de la investigaci\u00f3n en oncolog\u00eda debido a la falta de dianas terap\u00e9uticas y f\u00e1rmacos espec\u00edficos y el relativo mal pron\u00f3stico de las pacientes, especialmente aquellas con enfermedad en estadio avanzado que responden mal a la quimioterapia est\u00e1ndar y en las que el tumor progresa r\u00e1pidamente. El avance en el conocimiento de esta enfermedad compleja requiere un mejor conocimiento de su perfil molecular y el desarrollo de terapias espec\u00edficas dirigidas a dianas del c\u00e1ncer de mama triple negativo.
Investigadores del grupo de Gen\u00e9tica Humana del IDIBELL en colaboraci\u00f3n con investigadores del Instituto Catal\u00e1n de Oncolog\u00eda, el Centro tecnol\u00f3gico LEITAT y la Universidad de Barcelona han identificado un p\u00e9ptido (secuencia de amino\u00e1cidos) derivado de la prote\u00edna RCAN3 llamado R3178-210. Esta mol\u00e9cula inhibe significativamente el crecimiento tumoral y la angiog\u00e9nesis (formaci\u00f3n de nuevos vasos sangu\u00edneos que aportan nutrientes a las c\u00e9lulas tumorales) en un modelo de rat\u00f3n al que se ha implantado un tumor de mama triple negativo humano. Los resultados del estudio se han publicado en la revista Carcinogenesis.
\u00abNuestro trabajo no s\u00f3lo nos ha permitido averiguar nuevos mecanismos moleculares implicados en la progresi\u00f3n tumoral del c\u00e1ncer de mama\u00bb explica la investigadora Mercedes P\u00e9rez Riba, co-autora del estudio, \u00absino que muestra que el p\u00e9ptido R3178-210 posee potentes propiedades como supresor tumoral y, adem\u00e1s, es una nueva herramienta para el desarrollo de nuevos f\u00e1rmacos antitumorales potentes y espec\u00edficos\u00bb.
Sergio Mart\u00ednez-Hoyer, Sonia Sol\u00e9-S\u00e1nchez, Fernando Aguado, Sara Mart\u00ednez-Mart\u00ednez, Eva Serrano-Candelas, Jos\u00e9 Luis Hern\u00e1ndez, Mar Iglesias, Juan Miguel Redondo, Oriol Casanovas, Ramon Messeguer and Merced P\u00e9rez-Riba. A novel role for an RCAN3-derived peptide as a tumor suppressor in breast c\u00e1ncer. Carcinogenesis, 2015, 1-8. doi: 10.1093<\/p>\n","protected":false},"excerpt":{"rendered":"
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