{"id":10738,"date":"2015-07-27T00:00:00","date_gmt":"2015-07-26T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/es\/blog\/2015\/07\/27\/una-proteina-conservada-desde-bacterias-hasta-humanos-protege-de-los-golpes-de-calor\/"},"modified":"2020-05-20T16:00:19","modified_gmt":"2020-05-20T14:00:19","slug":"una-proteina-conservada-desde-bacterias-hasta-humanos-protege-de-los-golpes-de-calor","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2015\/07\/una-proteina-conservada-desde-bacterias-hasta-humanos-protege-de-los-golpes-de-calor\/","title":{"rendered":"Una prote\u00edna conservada desde bacterias hasta humanos protege de los golpes de calor"},"content":{"rendered":"<p>Investigadores del Instituto de Investigaci\u00f3n Biom\u00e9dica de Bellvitge (IDIBELL) en Barcelona, han descubierto que la prote\u00edna LSM-1 protege de los golpes de calor a los gusanos <em>Caernorhabditis elegans <\/em>que se utilizan como modelo animal en la investigaci\u00f3n. Solo los animales que tienen una mayor cantidad de esta prote\u00edna sobreviven a una subida dr\u00e1stica de la temperatura. <b><br \/> El grupo que lidera Juli\u00e1n Cer\u00f3n en el IDIBELL es especialista en <em>C. elegans<\/em>, un gusano milim\u00e9trico que se utiliza como modelo animal en la investigaci\u00f3n biom\u00e9dica. <b><br \/> En el estudio que publica la revista RNA, el investigador Eric Cornes observ\u00f3 que los gusanos transg\u00e9nicos que ten\u00edan niveles elevados de LSM-1 eran m\u00e1s resistentes a los <em>heat-shock<\/em>, termino en ingl\u00e9s usado para definir una subida brusca de la temperatura. Esta observaci\u00f3n fue corroborada aumentando los niveles de LSM-1 de distintas maneras y los resultados eran consistentes en todos los casos. Mientras una alta temperatura mataba al resto de gusanos, los que ten\u00edas niveles altos de LSM-1 sobreviv\u00edan. <b><br \/> \u201cLa asociaci\u00f3n de estos experimentos con las olas de calor veraniegas es inevitable ya que la prote\u00edna LSM-1 est\u00e1 conservada desde bacterias hasta humanos\u201d explica Juli\u00e1n Cer\u00f3n. <b><br \/> Cada a\u00f1o miles de muertes en el mundo son atribuibles<b><br \/> a las olas de calor. En 2003 en Europa murieron cerca de 70.000 personas por aspectos relacionados con las altas temperaturas. Y es que muchas patolog\u00edas se ven empeoradas por el calor. Adem\u00e1s, a la vista de los modelos de cambio clim\u00e1tico, el impacto negativo del calor sobre la salud est\u00e1 lejos de remitir. <b><br \/> Cuando los investigadores analizaron la secuencia de la prote\u00edna LSM-1, descubrieron que \u00e9sta ya exist\u00eda en las formas de vida m\u00e1s antigua: las arqueobacterias. LSM-1 tambi\u00e9n tiene la funci\u00f3n de proteger a las bacterias de los cambios en el ambiente. Por otro lado, en tumores humanos se ha descrito que esta prote\u00edna se encuentra presente a niveles por encima de los normales. Por lo tanto, se hipotetiza que altos niveles de esta prote\u00edna confieren capacidad para sobrevivir a c\u00e9lulas y organismos en ambientes desfavorables. <b><br \/> \u201cHemos relacionado a LSM-1 con una ruta metab\u00f3lica que est\u00e1 presente en todos los animales afirma el investigador Juli\u00e1n Cer\u00f3n. \u201cPor lo tanto, confiamos que este trabajo sirva para sentar las bases de nuevas l\u00edneas de investigaci\u00f3n que profundicen en la relaci\u00f3n de esta prote\u00edna con el metabolismo, la dieta, y la capacidad de sobrevivir a altas temperaturas\u201d <b><br \/> Cornes, E. Porta-de-la-Riva, M. Aristiz\u00e1bal-Corrales, D. Brokate-Llanos, AM. Garc\u00eda-Rodr\u00edguez, FJ. Ertl, I. D\u00edaz, M. Fontrodona, L. Reis, K. Johnsen, R. Baillie, D. Mu\u00f1oz, MJ. Sarov, M. Dupuy, D. Cer\u00f3n, J. <strong>Cytoplasmic LSM-1 protein regulates stress responses through the insulin\/IGF-1 signaling pathway in <em>C. elegans. <\/em><\/strong> Published in Advance July 6, 2015, doi: 10.1261\/rna.052324.115.<b><br \/> <b><br \/>RNA 2015. <a href=\"http:\/\/rnajournal.cshlp.org\/content\/early\/2015\/07\/03\/rna.052324.115?top=1\">http:\/\/rnajournal.cshlp.org\/content\/early\/2015\/07\/03\/rna.052324.115?top=1<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Protecci\u00f3n contra las altas temperaturas y olas de calor  Referencia  Cytoplasmic LSM-1 protein regulates stress responses through the insulin\/IGF-1 signaling pathway in C. elegans.<\/p>\n","protected":false},"author":6,"featured_media":10739,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[186,298,297],"tags":[275],"publishpress_future_action":{"enabled":false,"date":"2024-05-13 02:03:14","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10738"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=10738"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10738\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/10739"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=10738"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=10738"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=10738"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}