{"id":10734,"date":"2015-07-31T00:00:00","date_gmt":"2015-07-30T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/es\/blog\/2015\/07\/31\/descubren-la-perdida-de-un-gen-supresor-de-tumores-en-cancer-de-pulmon-de-celula-pequena\/"},"modified":"2020-05-20T15:55:23","modified_gmt":"2020-05-20T13:55:23","slug":"descubren-la-perdida-de-un-gen-supresor-de-tumores-en-cancer-de-pulmon-de-celula-pequena","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2015\/07\/descubren-la-perdida-de-un-gen-supresor-de-tumores-en-cancer-de-pulmon-de-celula-pequena\/","title":{"rendered":"Descubren la p\u00e9rdida de un gen supresor de tumores en c\u00e1ncer de pulm\u00f3n de c\u00e9lula peque\u00f1a"},"content":{"rendered":"<p>El c\u00e1ncer de pulm\u00f3n de c\u00e9lula peque\u00f1a es un tipo especial dentro de los tumores que aparecen en estos \u00f3rganos y constituyen el 15% de los mismos. Aparece casi exclusivamente en fumadores y suele debutar en el estadio de enfermedad diseminada, es decir, con la presencia de met\u00e1stasis. Se caracteriza por responder inicialmente bien a la quimioterapia, pero antes de un a\u00f1o el tumor reaparece y baja la supervivencia. <b><br \/> En comparaci\u00f3n al resto de tipos de c\u00e1ncer de pulm\u00f3n, el de c\u00e9lula peque\u00f1a no dispone de un tratamiento molecular personalizado, en parte debido a la dificultad de obtener material biol\u00f3gico para su estudio. Hoy, un art\u00edculo publicado en <em>Cancer Research, <\/em>la revista oficial de la Sociedad Americana para la Investigaci\u00f3n del C\u00e1ncer (AACR),<em> <\/em>dirigido por Manel Esteller, Director del Programa de Epigen\u00e9tica y Biolog\u00eda del C\u00e1ncer del Instituto de Investigaci\u00f3n Biom\u00e9dica de Bellvitge (IDIBELL), Investigador ICREA y Profesor de Gen\u00e9tica de la Universidad de Barcelona, proporciona una nueva alteraci\u00f3n gen\u00e9tica en este tipo c\u00e1ncer de pulm\u00f3n que ser\u00eda un buen candidato para el desarrollo de f\u00e1rmacos espec\u00edficos. <b><br \/> &#8220;Nuestras c\u00e9lulas tienen dos copias de cada gen. Y hemos descubierto que un 10% de los tumores de pulm\u00f3n de c\u00e9lula peque\u00f1a pierden ambas copias de un gen anti-c\u00e1ncer denominado KAT6B\u201d declara Manel Esteller, director del estudio. <b><br \/> &#8220;El gen identificado origina una prote\u00edna que es una histona acetiltransferasa, que nos podemos imaginar que es como una llave que abre nuestro ADN para que se expresen otros genes supresores de tumores. Cuando falta en una c\u00e9lula, su ADN se cierra sobre s\u00ed mismo y no deja expresarse a estos genes protectores, acelerando el proceso tumoral\u201d se\u00f1ala Esteller y concluye: \u201cpor suerte, parece ser que estas c\u00e9lulas tumorales a las que les falta este gen ser\u00edan m\u00e1s sensibles a un f\u00e1rmaco llamado irinotecan que act\u00faa a nivel del ADN. Nos gustar\u00eda comprobar ahora que los pacientes con esta alteraci\u00f3n tambi\u00e9n son mas sensibles a este compuesto en futuros ensayos cl\u00ednicos\u201d. <b><br \/> <strong>Art\u00edculo<\/strong>: <b><br \/> Simo-Riudalbas L, Perez-Salvia M, Setien F, Villanueva A, Moutinho C, Martinez-Cardus A, Moran S, Berdasco M, Gomez A, Vidal E, Soler M, Heyn H, Vaquero A, de la Torre C, Barcelo-Batllori S, Vidal A, Roz L, Pastorino U, Szakszon K, Borck G, Moura C, Carneiro F, Zondervan I, Savola S, Iwakawa R, Kohno T, Yokota J, <strong><span style=\"text-decoration: underline\">Esteller M.<\/span><\/strong> KAT6B is a tumor suppressor histone H3 lysine 23 acetyltransferase undergoing genomic loss in small cell lung cancer. <strong><em>Cancer Research<\/em><\/strong>, pii: canres.3702.2014, 2015.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Art\u00edculo Esteller M. Cancer Research<\/p>\n","protected":false},"author":6,"featured_media":10735,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[184,286],"tags":[],"class_list":["post-10734","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-area-cancer","category-epigenetica-del-cancer-cancer"],"publishpress_future_action":{"enabled":false,"date":"2025-05-03 01:09:15","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10734","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=10734"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10734\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/10735"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=10734"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=10734"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=10734"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}