{"id":10708,"date":"2015-10-08T00:00:00","date_gmt":"2015-10-07T22:00:00","guid":{"rendered":"https:\/\/idibell.cat\/es\/blog\/2015\/10\/08\/identifican-un-despertador-de-un-oncogen-causante-de-leucemia\/"},"modified":"2020-05-20T15:15:31","modified_gmt":"2020-05-20T13:15:31","slug":"identifican-un-despertador-de-un-oncogen-causante-de-leucemia","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2015\/10\/identifican-un-despertador-de-un-oncogen-causante-de-leucemia\/","title":{"rendered":"Identifican un \u2018despertador\u2019 de un oncog\u00e9n causante de leucemia"},"content":{"rendered":"<p>En los \u00faltimos treinta a\u00f1os se han descrito en el campo de la oncolog\u00eda una gran cantidad de mutaciones en genes implicados en m\u00faltiples v\u00edas celulares. La capacidad actual de secuenciar todo el material gen\u00e9tico de un tumor ha provocado que se hayan identificado un n\u00famero a\u00fan mayor de mutaciones en los tumores humanos. Sin embargo, sabemos muy poco de cu\u00e1les son las consecuencias para la actividad de las c\u00e9lulas de estos cambios en la estructura y composici\u00f3n del ADN.<b><br \/> <b><br \/> Hoy, un art\u00edculo publicado en<em> Oncogene, <\/em>dirigido por Manel Esteller, director del Programa de Epigen\u00e9tica y Biolog\u00eda del C\u00e1ncer del IDIBELL, Investigador ICREA y Profesor de Gen\u00e9tica de la Universidad de Barcelona, muestra como una mutaci\u00f3n en un gen tiene como consecuencia la activaci\u00f3n de un gen desencadenante de leucemia. <b><br \/> \u00abRecientemente se ha descubierto la existencia de mutaciones en el gen DNMT3A en leucemias. Parec\u00eda que la historia se paraba aqu\u00ed. Pero como este gen se encarga de silenciar a otros genes que no deben estar activos en la c\u00e9lula, nos preguntamos qu\u00e9 secuencia de ADN estaba siendo \u201c<em>despertada<\/em>\u201d por la mutaci\u00f3n en las leucemias\u201d ha explicado Manel Esteller, director del estudio. <b><br \/> <b><br \/> \u00abAnalizando todo el genoma de c\u00e9lulas leuc\u00e9micas portadoras de la mutaci\u00f3n, nos dimos cuenta de que el gen diana activado era el denominado oncog\u00e9n MEIS1. Se trata de un poderoso gen inductor de leucemia mieloide aguda del cual se sab\u00eda su funci\u00f3n proleuc\u00e9mica, pero no como se pon\u00eda en marcha. La mutaci\u00f3n del otro gen lo explica\u2026\u201d se\u00f1ala el investigador. <b><br \/> \u201cPodemos imaginarlo como un castillo con naipes. Si quitas la carta de la fila inferior (DNMT3A) acaban cayendo todas las capas superiores, como es el caso del oncog\u00e9n MEIS1. El hallazgo, adem\u00e1s de su utilidad en la predicci\u00f3n de pacientes con leucemias de mal pron\u00f3stico, sugiere que este subtipo de leucemia podr\u00eda ser sensible a f\u00e1rmacos que tuvieran como diana los dos genes estudiados\u201d. <strong>Art\u00edculo<\/strong>: <b><br \/> Ferreira HJ, Heyn H, Vizoso M, Moutinho C, Vidal E, Gomez A, Martinez-Cardus A, Simo-Riudalbas L, Moran S, Jost E, <strong>Esteller M<\/strong>. DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia. <strong><em>Oncogene<\/em><\/strong>, October 5th, 2015.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Art\u00edculo Esteller M Oncogene<\/p>\n","protected":false},"author":6,"featured_media":10709,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[184,286],"tags":[],"class_list":["post-10708","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-area-cancer","category-epigenetica-del-cancer-cancer"],"publishpress_future_action":{"enabled":false,"date":"2024-12-30 01:32:27","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10708","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=10708"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10708\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/10709"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=10708"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=10708"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=10708"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}