{"id":10644,"date":"2016-01-25T00:00:00","date_gmt":"2016-01-24T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/es\/blog\/2016\/01\/25\/c-elegans-como-modelo-en-el-estudio-del-cancer-en-las-revistas-genetics-y-nature-medicine\/"},"modified":"2020-05-20T12:47:47","modified_gmt":"2020-05-20T10:47:47","slug":"c-elegans-como-modelo-en-el-estudio-del-cancer-en-las-revistas-genetics-y-nature-medicine","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2016\/01\/c-elegans-como-modelo-en-el-estudio-del-cancer-en-las-revistas-genetics-y-nature-medicine\/","title":{"rendered":"C. elegans como modelo en el estudio del c\u00e1ncer, en las revistas Genetics y Nature Medicine"},"content":{"rendered":"<p>El nematodo <em>Caernorhabditis elegans<\/em> es usado el laboratorio del Dr. Juli\u00e1n Cer\u00f3n como modelo de estudio de enfermedades. El grupo acaba de publicar dos trabajos relacionados con c\u00e1ncer, uno en la <em>Genetics<\/em> y el otro en <em>Nature Medicine<\/em>. <b><br \/> El art\u00edculo publicado en <em>Genetics <\/em>es fruto de la tesis doctoral de la estudiante austriaca Iris Ertl, que ha sido dirigida por el Dr Cer\u00f3n. Iris y colaboradores han usado aproximaciones gen\u00e9ticas, transcript\u00f3micas y prote\u00f3micas para estudiar dos prote\u00ednas del complejo SWI\/SNF que son mutuamente excluyentes y que est\u00e1n conservadas desde levaduras hasta humanos. Las prote\u00ednas hom\u00f3logas humanas (SMARCD1, SMARCD2 y SMARCD3) se han encontrado desreguladas en distintos tipos de tumores de modo que este trabajo en <em>C. elegans<\/em> ayuda a explicar la especificidad de las patolog\u00edas relacionadas con estas prote\u00ednas y sugiere el estudio de interacciones sint\u00e9ticas letales como aproximaci\u00f3n terap\u00e9utica. Uno de los hallazgos m\u00e1s relevantes es la interacci\u00f3n f\u00edsica y funcional entre componentes del complejo SWI\/SNF y prote\u00ednas de la membrana nuclear. <b><br \/> Por otro lado, en un trabajo liderado por el Dr L\u00f3pez Ot\u00edn de la Universidad de Oviedo y publicado en <em>Nature Medicine<\/em>, se ha descubierto que la alteraci\u00f3n de la prote\u00edna AIRAPL causa neoplasmas proliferativos por medio de un mecanismo que depende de la v\u00eda de se\u00f1alizaci\u00f3n de la insulina. La Dra Montserrat Porta, por medio de la plataforma de <em>C. elegans<\/em>, ha realizado ensayos de longevidad y RNA de interferencia para demostrar que la relaci\u00f3n funcional entre la prote\u00edna AIRAPL y la v\u00eda metab\u00f3lica de la insulina ya existe en gusanos, lo cual sit\u00faa a <em>C. elegans <\/em>como modelo precl\u00ednico en el que manipular dicha relaci\u00f3n funcional. <b><br \/> <b><br \/> Referencias de los art\u00edculos: <b><br \/> Functional Interplay of Two Paralogs Encoding SWI\/SNF Chromatin-Remodeling Accessory Subunits During Caenorhabditis elegans Development. Ertl I, Porta-de-la-Riva M, G\u00f3mez-Orte E, Rubio K, Aristiz\u00e1bal-Corrales D, Cornes E, Fontrodona L, Osteikoetxea X, Ayuso C, Askjaer P, Cabello J, Cer\u00f3n J*. <strong><em>Genetics<\/em><\/strong>. 2016 Jan 6. pii: genetics.115.183533. <b><br \/> Loss of the proteostasis factor AIRAPL causes myeloid transformation by deregulating IGF-1 signaling. Osorio FG, Soria-Valles C, Santiago-Fern\u00e1ndez O, Bernal T,2, Mittelbrunn M, Colado E, Rodr\u00edguez F, Bonzon-Kulichenko E, V\u00e1zquez J, <strong>Porta-de-la-Riva M, Cer\u00f3n J,<\/strong> Fueyo A Li J, Green AR1, Freije JM, L\u00f3pez-Ot\u00edn C. <strong>Nature Medicine. <\/strong>2016 Jan;22(1):91-6.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Genetics Porta-de-la-Riva M, Cer\u00f3n J, Nature Medicine.<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[186,298,297],"tags":[275],"publishpress_future_action":{"enabled":false,"date":"2024-05-08 00:28:03","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10644"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=10644"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10644\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=10644"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=10644"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=10644"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}