{"id":10636,"date":"2016-02-12T00:00:00","date_gmt":"2016-02-11T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/es\/blog\/2016\/02\/12\/eva-gonzalez-suarez-obtiene-una-consolidator-grant-del-european-research-council\/"},"modified":"2020-05-20T10:50:16","modified_gmt":"2020-05-20T08:50:16","slug":"eva-gonzalez-suarez-obtiene-una-consolidator-grant-del-european-research-council","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2016\/02\/eva-gonzalez-suarez-obtiene-una-consolidator-grant-del-european-research-council\/","title":{"rendered":"Eva Gonz\u00e1lez Su\u00e1rez obtiene una Consolidator Grant del European Research Council"},"content":{"rendered":"<p><strong>La jefa del grupo de Transformaci\u00f3n y Met\u00e1stasis del PEBC-IDIBELL, Eva Gonz\u00e1lez Su\u00e1rez ha recibido una ERC Consolidator Grant del European Research Council (ERC) para desarrollar su proyecto PLEIO-RANK dirigido a desarrollar una terapia \u00fanica capaz de reducir la met\u00e1stasis y la mortalidad en tumores s\u00f3lidos. La beca supone una financiaci\u00f3n de 2 millones de Euros para los pr\u00f3ximos cinco a\u00f1os.<\/strong> <b><br \/> <b><br \/> Miles de pacientes de c\u00e1ncer en todo el mundo est\u00e1n tomando inhibidores de RANKL para el manejo de las met\u00e1stasis \u00f3seas, basado en el papel clave de RANKL y su receptor, RANK, en los osteoclastos. \u201cHemos demostrado\u201d explica la investigadora \u201cque la sobreexpresi\u00f3n de RANK induce stemness, interfiere en la diferenciaci\u00f3n en c\u00e9lulas epiteliales mamarias no transformadas y promueve los primeros pasos de la tumorog\u00e9nesis mamaria actuando como un mediador paracrino de la progesterona\u201d. <b><br \/> \u201cEl proyecto PLEIO-RANK\u201d a\u00f1ade \u201cpretende explorar el potencial terap\u00e9utico de la inhibici\u00f3n de la se\u00f1alizaci\u00f3n de RANK en otros tumores s\u00f3lidos, no s\u00f3lo como una estrategia preventiva, sino tambi\u00e9n durante la progresi\u00f3n del tumor, recurrencia y met\u00e1stasis. Vamos a diseccionar el papel de esta v\u00eda en las c\u00e9lulas tumorales y en el estroma circundante\u201d. La inhibici\u00f3n de RANK podr\u00eda convertirse en una terapia \u00fanica dirigida a reducir la met\u00e1stasis y la mortalidad en los tumores s\u00f3lidos por sus efectos antitumorales pleiotr\u00f3picos en las c\u00e9lulas cancerosas y del estroma. <b><br \/> Las Consolidator Grants tienen como objetivo impulsar la carrera de investigadores con talento y visi\u00f3n innovadora que hayan demostrado su potencial investigador y su madurez cient\u00edfica. <b><br \/> <a class=\"enllac\" href=\"https:\/\/erc.europa.eu\/media-and-events\/press-releases\">Enlace a la informaci\u00f3n difundida por la ERC<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>La jefa del grupo de Transformaci\u00f3n y Met\u00e1stasis del PEBC-IDIBELL, Eva Gonz\u00e1lez Su\u00e1rez ha recibido una ERC Consolidator Grant del European Research Council (ERC) para desarrollar su proyecto PLEIO-RANK dirigido a desarrollar una terapia \u00fanica capaz de reducir la met\u00e1stasis y la mortalidad en tumores s\u00f3lidos. La beca supone una financiaci\u00f3n de 2 millones de Euros para los pr\u00f3ximos cinco a\u00f1os.<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[184,223],"tags":[123],"publishpress_future_action":{"enabled":false,"date":"2024-05-11 13:38:00","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10636"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=10636"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10636\/revisions"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=10636"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=10636"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=10636"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}