{"id":10520,"date":"2016-12-21T00:00:00","date_gmt":"2016-12-20T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/es\/blog\/2016\/12\/21\/describen-las-causas-de-la-resistencia-de-las-celulas-tumorales-a-la-terapia-con-inhibidores-de-mtor\/"},"modified":"2020-05-20T09:20:17","modified_gmt":"2020-05-20T07:20:17","slug":"describen-las-causas-de-la-resistencia-de-las-celulas-tumorales-a-la-terapia-con-inhibidores-de-mtor","status":"publish","type":"post","link":"https:\/\/idibell.cat\/es\/2016\/12\/describen-las-causas-de-la-resistencia-de-las-celulas-tumorales-a-la-terapia-con-inhibidores-de-mtor\/","title":{"rendered":"Describen las causas de la resistencia de las c\u00e9lulas tumorales a la terapia con inhibidores de mTOR"},"content":{"rendered":"<p>Investigadores del grupo de investigaci\u00f3n en c\u00e1ncer de mama del programa proCURE ICO-IDIBELL han descrito por primera vez por qu\u00e9 los tumores se adaptan y resisten a la terapia con inhibidores de mTOR, un tratamiento empleado en estadios avanzados de este tipos de c\u00e1ncer. Los resultados de este estudio internacional, publicados en la revista <em>Oncogene<\/em>, permiten establecer nuevos pasos hacia una selecci\u00f3n m\u00e1s personalizada de terapias en c\u00e1ncer. <b><br \/> La v\u00eda de se\u00f1alizaci\u00f3n molecular de mTOR posee un papel central en el c\u00e1ncer. Sin embargo, la inhibici\u00f3n de mTOR en monoterapia ha dado resultados muy limitados en la lucha contra diversos tipos tumorales. \u00abEn este estudio, demostramos que las c\u00e9lulas tumorales son capaces de adaptarse al tratamiento a trav\u00e9s de un cambio de fenotipo que las hace m\u00e1s agresivas y sostiene su potencial metast\u00e1sico\u00bb, explica el Dr. Miguel \u00c1ngel Pujana, \u00faltimo autor del estudio. <b><br \/> As\u00ed, la terapia con inhibidores induce una reorganizaci\u00f3n de la expresi\u00f3n g\u00e9nica que sustenta la v\u00eda de se\u00f1alizaci\u00f3n mTOR y permite a las c\u00e9lulas cancer\u00edgenas colonizar otros tejidos y \u00f3rganos. \u00abPor lo tanto, s\u00f3lo a trav\u00e9s de terapias combinadas que impidan la reorganizaci\u00f3n g\u00e9nica ser\u00e1 viable que los inhibidores de mTOR muestren beneficio de forma global\u00bb, concluye el investigador.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Investigadores del grupo de investigaci\u00f3n en c\u00e1ncer de mama del programa proCURE ICO-IDIBELL han descrito por primera vez por qu\u00e9 los tumores se adaptan y resisten a la terapia con inhibidores de mTOR, un tratamiento empleado en estadios avanzados de este tipos de c\u00e1ncer. Los resultados de este estudio internacional, publicados en la revista Oncogene, [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":10521,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[184,292,281],"tags":[],"class_list":["post-10520","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-area-cancer","category-cancer-de-mama-cancer-2","category-programa-de-mecanismos-moleculares-y-terapia-experimental-en-oncologia-oncobell"],"publishpress_future_action":{"enabled":false,"date":"2024-12-25 22:11:06","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10520","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=10520"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10520\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/10521"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=10520"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=10520"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=10520"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}