En 2018 hubo en el mundo 1,7 millones de muertes por c\u00e1ncer de pulm\u00f3n, el equivalente a la poblaci\u00f3n de la ciudad de Barcelona. La alta tasa de mortalidad de los pacientes con c\u00e1ncer de pulm\u00f3n refleja la necesidad de desarrollar nuevas terapias m\u00e1s eficaces.<\/p>\n
\u00a0<\/p>\n
Un estudio, liderado por el Dr. \u00c1ngel R. Nebreda investigador del Instituto de Investigaci\u00f3n Biom\u00e9dica (IRB Barcelona), en el que han colaborado el Dr. Mariano Barbacid del Centro Nacional de Investigaciones Oncol\u00f3gicas (CNIO) y el Dr. Alberto Villanueva del programa del IDIBELL ONCOBELL (ProCure-ICO), y que se ha publicado en la revista PNAS. Demuestra que la prote\u00edna p38 es uno de los pilares en los que se sustentan las c\u00e9lulas tumorales de pulm\u00f3n. En concreto, el trabajo se centra en c\u00e9lulas que expresan el oncog\u00e9n Kras, causante de la transformaci\u00f3n de una c\u00e9lula sana en una c\u00e9lula tumoral y cuyas mutaciones son las responsables del 25% de los casos de c\u00e1ncer de pulm\u00f3n.<\/p>\n
\u00a0<\/p>\n
La importancia de este trabajo reside en que \u201cmuestra c\u00f3mo los tumores se aprovechan, para su progresi\u00f3n, de una prote\u00edna que en principio proteg\u00eda a las c\u00e9lulas sanas del pulm\u00f3n\u201d se\u00f1ala Jessica Vitos, primera autora del art\u00edculo. El resultado del estudio puede tener aplicaci\u00f3n terap\u00e9utica, \u201cya que los compuestos qu\u00edmicos que inhiban la funci\u00f3n de p38 interferir\u00edan con el crecimiento de los tumores de pulm\u00f3n\u201d, contin\u00faa.<\/p>\n
\u00a0<\/p>\n
El estudio ha contado con financiaci\u00f3n del Consejo Europeo de Investigaci\u00f3n (ERC), el Ministerio de Ciencia, Innovaci\u00f3n y Universidades, la Ag\u00e8ncia de Gesti\u00f3 d’Ajuts Universitaris i de Recerca de la Generalitat de Catalunya (AGAUR) y la Fundaci\u00f3n BBVA.<\/p>\n","protected":false},"excerpt":{"rendered":"
Los estudios realizados muestran que los pacientes con niveles m\u00e1s bajos de esta prote\u00edna presentan mejores pron\u00f3sticos.<\/p>\n","protected":false},"author":6,"featured_media":10073,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[184,206],"tags":[],"publishpress_future_action":{"enabled":false,"date":"2024-05-04 17:30:52","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10072"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=10072"}],"version-history":[{"count":1,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10072\/revisions"}],"predecessor-version":[{"id":23462,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/posts\/10072\/revisions\/23462"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/10073"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=10072"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/categories?post=10072"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=10072"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}