{"id":2764,"date":"2019-10-07T23:45:16","date_gmt":"2019-10-07T21:45:16","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2764"},"modified":"2024-12-17T12:43:25","modified_gmt":"2024-12-17T11:43:25","slug":"enfermedades-sistemicas-vasculares-y-envejecimiento","status":"publish","type":"page","link":"https:\/\/idibell.cat\/es\/investigacion\/area-de-medicina-traslacional\/programa-de-enfermedades-cardiovasculares-respiratorias-sistemicas-y-de-envejecimiento-celular\/enfermedades-sistemicas-vasculares-y-envejecimiento\/","title":{"rendered":"Enfermedades Sist\u00e9micas, Vasculares y Envejecimiento"},"content":{"rendered":"\n
El grupo de Enfermedades Sist\u00e9micas, Vasculares y Envejecimiento estudia el impacto y el tratamiento de las enfermedades sist\u00e9micas (es decir, enfermedades que afectan a m\u00e1s de un \u00f3rgano) desde la perspectiva cl\u00ednica y epidemiol\u00f3gica hasta el entorno del laboratorio. Su \u00e1rea de experiencia incluye los campos de las enfermedades autoinmunes sist\u00e9micas, la enfermedad tromboemb\u00f3lica venosa, el envejecimiento (principalmente insuficiencia card\u00edaca cr\u00f3nica) y las telangiectasias hereditarias hemorr\u00e1gicas y otras enfermedades raras vasculares. En cuanto a las enfermedades raras, este grupo tambi\u00e9n estudia estas enfermedades desde la investigaci\u00f3n b\u00e1sica, con modelos celulares y animales. De hecho, practicamos una verdadera investigaci\u00f3n traslacional, transfiriendo los conocimientos de un entorno de laboratorio a uno cl\u00ednico, evitando cualquier brecha en la transici\u00f3n entre ambos entornos.<\/p>\n
Arribas V, Onetti Y, Ramiro-Pareta M, Villacampa P, Beck H, Alberola M, Esteve-Codina A, Merkel A, Sperandio M, Mart\u00ednez-Estrada OM, Schmid B, Montanez E. Endothelial TDP-43 controls sprouting angiogenesis and vascular barrier integrity, and its deletion triggers neuroinflammation<\/strong>. JCI Insight. 2024 Feb 1:e177819. doi: 10.1172\/jci.insight.177819. Epub ahead of print. PMID: 38300714.<\/p>\n Cand\u00e1s-Est\u00e9banez B, Fern\u00e1ndez-Cid\u00f3n B, Corbella E, Teb\u00e9 C, Fanlo-Maresma M, Esteve-Luque V, Salas-Salvad\u00f3 J, Fit\u00f3 M, Riera-Mestre A, Ros E, Pint\u00f3 X. The Impact of the Mediterranean Diet and Lifestyle Intervention on Lipoprotein Subclass Profiles among Metabolic Syndrome Patients: Findings of a Randomized Controlled Trial.<\/strong> Int J Mol Sci. 2024 Jan 22;25(2):1338. doi: 10.3390\/ijms25021338. PMID: 38279337; PMCID: PMC10817060.<\/p>\n Genet G, Genet N, Paila U, Cain SR, Cwiek A, Chavkin NW, Serbulea V, Figueras A, Cerd\u00e0 P, McDonnell SP, Sankaranarayanan D, Huba M, Nelson EA, Riera-Mestre A, Hirschi KK. Induced Endothelial Cell CycleArrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia<\/strong>. Circulation. 2023 Dec 21. doi: 10.1161\/CIRCULATIONAHA.122.062952. Epub ahead of print. PMID: 38126211.<\/p>\n Bastard P, Vazquez S, Liu J, Laurie MT, Wang CY, Gervais A, Le Voyer T, Bizien L, Zamecnik C, Philippot Q, Rosain J, Catherinot E, Willmore A, Mitchell AM, Bair R, Gar\u00e7on P, Kenney H, Fekkar A, Salagianni M, Poulakou G, Siouti E, Sahanic S, Tancevski I, Weiss G, Nagl L, Manry J, Duvlis S, Arroyo S\u00e1nchez D, Paz Artal E, Rubio L, Perani C, Bezzi M, Sottini A, Quaresima V, Roussel L, Vinh DC, Reyes LF, Garzaro M, Hatipoglu N, Boutboul D, Tandjaoui Lambiotte Y, Borghesi A, Aliberti A, Cassaniti I, Venet F, Monneret G, Halwani R, Sharif Askari NS, Danielson J, Burrel S, Morbieu C, Stepanovskyy Y, Bondarenko A, Volokha A, Boyarchuk O, Gagro A, Neuville M, Neven B, Hernu R, Bal A, Novelli A, Novelli G, Saker K, Ailioaie O, Antol\u00ed A, Jeziorski E, Rocamora Blanch G, Teixeira C, Delaunay C, Lhuillier M, Le Turnier P, Zhang Y, Mahevas M, Pan Hammarstr\u00f6m Q, Abolhassani H, Bompoil T, Dorgham K, COVID HGE consortium \u2020, French COVID study group \u2020, COMET consortium \u2020, Gorochov G, Laouenan C, Rodr\u00edguez Gallego C, NGLFP, Renia L, Pujol A, Belot A, Raffi F, Allende LM, Martinez Picado J, Ozcelik T, Keles S, Imberti L, Notarangelo LD, Troya J, Solanich X, Zhang SY, Puel A, Wilson MR, Trouillet Assant S, Abel L, Jouanguy E, Ye CJ, Cobat A, Thompson LM, Andreakos E, Zhang Q, Anderson MS, Casanova JL, DeRisi JL. Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs<\/strong>. Sci. Immunol. 2022;doi:10.1126\/sciimmunol.abp8966.<\/p>\n Corsonello A, Soraci L, \u00c4rnl\u00f6v J, Carlsson AC, Roller Wirnsberger R, Wirnsberger G, Mattace Raso F, Tap L, Formiga F, Moreno Gonz\u00e1lez R, Kostka T, Guligowska A, Artzi Medvedik R, Melzer I, Weingart C, Sieber C, Lattanzio F, Screening for among Older People across Europe (SCOPE) study investigators CKD. The relevance of geriatric assessments on the association between chronic kidney disease stages and mortality among older people: a secondary analysis of a multicentre cohort study.<\/strong> Age Ageing. 2022;51(7):doi:10.1093\/ageing\/afac168.<\/p>\n\t\t\t\t\tProyectos seleccionados<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t PI23\/00651. Papel de los autoanticuerpos que neutralizan interferones de tipo I en el lupus eritematoso sist\u00e9mico<\/strong>. AES2023. Budget: 202.500,00 \u20ac. 2024-2026. PI:\u00a0 Solanich Moreno, Xavier<\/p>\n PID2022-141840OB-I00. Deciphering the role of TDP-43 in angiogenesis, vascular barrier and homostasis of blood vessels under both physiological and pathological conditions.<\/strong> (NeuVasTDP43). Budget: 200.000\u20ac. 2023-2026. PI: Monta\u00f1ez Miralles, Eloi.<\/p>\n CNS2023-144390. Caracterizaci\u00f3n de un nuevo modelo animal de fibrosis retinal mediada por pericitos.<\/strong> Consolidaci\u00f3n Investigadora 2023 (MCINN). Budget: 199.890,34 \u20ac 2023-2025. PI:\u00a0 Villacampa Alcubierre, Pilar.<\/p>\n PI23\/00164. Nuevo conocimiento en el desarrollo de malformaciones vasculares hep\u00e1ticas en los pacientes con Telangiectasia Hemorr\u00e1gica Hereditaria<\/strong> . Proyectos de investigaci\u00f3n en Salud (AES 2023).\u00a0 Budget: 167.500\u20ac. 2024-2027. PI: Riera Mestre, Antoni.<\/p>\n 2023-713-1. Desxifrar el paper de TDP-43 en la barrera vascular i l’estabilitat dels vasos sanguinis<\/strong>. La Marat\u00f3 TV3 2022. Budget: 120.000\u20ac. PI: Monta\u00f1ez Miralles, Eloi.<\/p>\n\t\t\t\t\n Enfermedades sist\u00e9micas, vasculares y envejecimiento Resumen El grupo de Enfermedades Sist\u00e9micas, Vasculares y Envejecimiento estudia el impacto y el tratamiento de las enfermedades sist\u00e9micas (es decir, enfermedades que afectan a m\u00e1s de un \u00f3rgano) desde la perspectiva cl\u00ednica y epidemiol\u00f3gica hasta el entorno del laboratorio. Su \u00e1rea de experiencia incluye los campos de las enfermedades […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":568,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-2764","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2024-12-25 07:24:06","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/2764","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=2764"}],"version-history":[{"count":10,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/2764\/revisions"}],"predecessor-version":[{"id":25323,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/2764\/revisions\/25323"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/568"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=2764"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\n\t\tRiera Mestre, Antoni\n\t<\/h4>\n
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\n\t\tInvestigadores principales\n\t<\/h2>\n\t\t\t\t\n
\n\t\tRiera Mestre, Antoni\n\t<\/h4>\n
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\n\t\t\n\t\txpinto@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tSolanich Moreno, Xavier\n\t<\/h4>\n
\n\t\t\n\t\txsolanich@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tMonta\u00f1ez Miralles, Eloi\n\t<\/h4>\n
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\n\t\tFormiga P\u00e9rez, Francesc\n\t<\/h4>\n
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\n\t\tEquipo\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tJefes\/as de grupo\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as principales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as cl\u00ednicos\/as\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as postdoctorales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as predoctorales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tSoporte cient\u00edfico\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tColaboradores\/as\t\t\t\t<\/a>\n\t\t\t\t\t\tJefes\/as de grupo\n\t\t\t\t\t\t\t\t\t\t\t
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\n\t\tNoticias relacionadas\n\t<\/h2>\n\t\t\n\t\t\t\t<\/a>\n\t\t\tBellvitge contribuye a una mejora significativa en el tratamiento del angioedema hereditario<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t05\/07\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa integridad de la barrera hematoencef\u00e1lica depende de una prote\u00edna que est\u00e1 alterada en algunas enfermedades neurodegenerativas<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t13\/03\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa IV Jornada de Enfermedades Minoritarias de Bellvitge reivindica el papel clave de los rean\u00e1lisis gen\u00e9ticos<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t24\/10\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tEl Dr. Riera-Mestre, elegido editor de la revista m\u00e1s prestigiosa en el \u00e1mbito de las enfermedades minoritarias<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t23\/06\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa Generalitat reconoce a 32 grupos del IDIBELL como Grupos de Investigaci\u00f3n Consolidados o Emergentes<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t18\/04\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa tesis doctoral del Dr. Xavier Solanich, galardonada por la SCBMI<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t02\/06\/2022\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLas vacunas contra el SARS-CoV-2 son seguras y eficaces en las personas con inmunodeficiencia<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t05\/05\/2022\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\t\u00a1Cerramos un 2021 lleno de ciencia!<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t30\/12\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa medicina personalizada, uno de los pilares del IDIBELL<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t16\/12\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tDescriben dos nuevas variantes del gen TLR7 que se asocian a formas graves de la COVID-19 en hombres j\u00f3venes y sanos<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t26\/07\/2021\t\t\t\t\t\t\t\n\t\t\n\n","protected":false},"excerpt":{"rendered":"