{"id":2669,"date":"2019-10-07T14:19:01","date_gmt":"2019-10-07T12:19:01","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2669"},"modified":"2024-06-20T12:51:24","modified_gmt":"2024-06-20T10:51:24","slug":"fisiologia-y-patologia-de-la-relacion-funcional-glia-neurona","status":"publish","type":"page","link":"https:\/\/idibell.cat\/es\/investigacion\/area-de-medicina-traslacional\/programa-de-genes-enfermedad-y-terapia\/fisiologia-y-patologia-de-la-relacion-funcional-glia-neurona\/","title":{"rendered":"Fisiolog\u00eda y Patolog\u00eda de la Relaci\u00f3n Funcional Glia-neurona"},"content":{"rendered":"\n<h1>\n\t\tFisiolog\u00eda y patolog\u00eda de la relaci\u00f3n funcional glia-neurona\n\t<\/h1>\n<h3>\n\t\tResumen\n\t<\/h3>\n\t<p>El cloruro es el ani\u00f3n m\u00e1s abundante en organismos. Los canales de cloro de membrana plasm\u00e1ticos de la familia CLC i LRRC8 son importantes para varias funciones fisiol\u00f3gicas, como la regulaci\u00f3n de la excitabilidad a las c\u00e9lulas nerviosas y el m\u00fasculo, tanto para la regulaci\u00f3n del volumen celular como para el transporte transepitelial. Los roles fisiol\u00f3gicos de varios canales de cloro son ilustrados en enfermedades hereditarias humanas causadas por mutaciones en los genes o subunidades auxiliares que regulan sus funciones. El objetivo del grupo es, pues, intentar comprender la regulaci\u00f3n del canal de cloro para proporcionar soluciones terap\u00e9uticas a los pacientes afectados. Utilizamos un enfoque multidisciplinar aplicando m\u00e9todos de imagen, electrofisiolog\u00eda y bioqu\u00edmica en\u00a0 modelos de ratones y pez cebra.<\/p>\n<h2>73<\/h2>\n<h2>Publicaciones<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/es\/wp-content\/uploads\/sites\/4\/2020\/04\/rat_hippocampus_stained_with_antibody_to_neun_green_myelin_basic_protein_red_and_dna_blue.jpg\" alt=\"rat_hippocampus_stained_with_antibody_to_neun_green_myelin_basic_protein_red_and_dna_blue\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"rat_hippocampus_stained_with_antibody_to_neun_green_myelin_basic_protein_red_and_dna_blue\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">L\u00edneas estrat\u00e9gicas<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\"><i>Expand<\/i><\/a>\n\t\t\t\t\tPapel de canales de cloruro gliales en la homeostasis del cerebro.<br \/>\nEnfermedades gen\u00e9ticas raras causadas por la disfunci\u00f3n de canales de cloruro.<br \/>\nRegulaci\u00f3n de canales i\u00f3nicos por prote\u00ednas reguladoras. Estructura-funci\u00f3n de canales i\u00f3nicos y desarrollo de inhibidores espec\u00edficos dirigidos a canales i\u00f3nicos\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Publicaciones seleccionadas<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>MAYAYO VALLVERDU,C;FERIGLE BURGADA,L;VECINO PEREZ,M;Lara,J;NUNES MARTINEZ,V;Estevez Povedano,R, <strong>Characterization of an MLC patient carrying two MLC1 variants showing radiological improvement<\/strong>, Brain Disord, 2023;11100079-doi:10.1016\/j.dscb.2023.100079<\/li>\n<li>Wang,BB;Xu,H;Isenmann,S;Huang,C;Elorza Vidal,X;Rychkov,GY;Est\u00e9vez,R et al, <strong>Ubr1-induced selective endophagy\/autophagy protects against the endosomal and Ca(2+)-induced proteostasis disease stress<\/strong>., Cell. Mol. Life Sci., 2022;79(3):167-167, doi:10.1007\/s00018-022-04191-8<\/li>\n<li>Pla Casillanis,A;Ferigle,L;Alonso Gard\u00f3n,M;Xicoy Espaulella,E;Errasti Murugarren,E;Marazziti,D;Est\u00e9vez,R, <strong>GPR37 Receptors and Megalencephalic Leukoencephalopathy with Subcortical Cysts<\/strong>., Int. J. Mol. Sci., 2022;23(10):doi:10.3390\/ijms23105528<\/li>\n<li>Formaggio,F;Fazzina,M;Est\u00e9vez,R;Caprini,M;Ferroni,S, <strong>Dynamic expression of homeostatic ion channels in differentiated cortical astrocytes in vitro<\/strong>., Pflugers Arch., 2022;474(2):243-260, doi:10.1007\/s00424-021-02627-x<\/li>\n<li>Alonso Gardon M, Elorza Vidal X, Castellanos A, La Sala G, Armand Ugon M, Gilbert A, Di Pietro C, Pla Casillanis A, Ciruela F, Gasull X, Nunes V, Martinez A, Schulte U, Cohen Salmon M, Marazziti D, Estevez R. <strong>Identification of the GlialCAM interactome: the G protein-coupled receptors GPRC5B and GPR37L1 modulate megalencephalic leukoencephalopathy proteins<\/strong>. Hum. Mol. Genet. 2021;30(17):1649-1665. doi:10.1093\/hmg\/ddab155.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Proyectos seleccionados<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<p>&#8211; 18MAR001. Development of novel inhibitors of the chloride channel LRRC8\/VRAC, a novel player in ischemia. (201710.30). FUNDACIO IDIBELL; FUNDACI\u00d3 LA MARAT\u00d3 DE TV3; UNIVERSITAT DE BARCELONA. Importe Concedido:199.936,53\u20ac 2018-2021. IP:ESTEVEZ POVEDANO,RAUL.<\/p>\n<p>&#8211; Regulation of chloride channels in health and disease. UB. MICINN. 242000 \u20ac. 2019-2021<\/p>\n<p>&#8211; Estudios iniciales para determinar la estructura 3D de MLC1. CIBERER. 40000 \u20ac 2020-2021<\/p>\n<p>&#8211; Characterization of a zebrafish model of myotonia congenita. CIBERER. 40000 \u20ac 2021-2022<\/p>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/10\/estevez-povedano-raul-150x150.jpg\" alt=\"Estevez Povedano, Raul\" itemprop=\"image\" title=\"estevez-povedano-raul\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tEstevez Povedano, Raul\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:restevez@idibell.cat\" title=\"restevez@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\trestevez@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tInvestigadores principales\n\t<\/h2>\n\t\t\t\t<img decoding=\"async\" src=\"https:\/\/idibell.cat\/wp-content\/uploads\/2019\/10\/estevez-povedano-raul-150x150.jpg\" alt=\"Estevez Povedano, Raul\" itemprop=\"image\" title=\"estevez-povedano-raul\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tEstevez Povedano, Raul\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:restevez@idibell.cat\" title=\"restevez@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\trestevez@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/es\/wp-content\/uploads\/sites\/4\/2023\/11\/Tania-Lopez-Hernandez.jpg\" alt=\"Tania-L\u00f3pez-Hern\u00e1ndez\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Tania-L\u00f3pez-Hern\u00e1ndez\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tL\u00f3pez Hern\u00e1ndez, Tania\n\t<\/h4>\n<h2>\n\t\tEquipo\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tJefes\/as de grupo\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadores\/as principales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadores\/as postdoctorales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadores\/as predoctorales\t\t\t\t<\/a>\n\t\t\t\t\t\tJefes\/as de grupo\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Estevez Povedano, Raul<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadores\/as principales\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>L\u00f3pez Hern\u00e1ndez, Tania<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadores\/as postdoctorales\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Gait\u00e1n Pe\u00f1as, H\u00e9ctor<\/li>\n<li>Pla Casillanis, Adri\u00e0<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadores\/as predoctorales\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Ferigle Burgada, Laura<\/li>\n<\/ul>\n<h2>\n\t\tNoticias relacionadas\n\t<\/h2>\n\t<meta itemscope 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itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/11340\" content=\"Un paso m\u00e1s en la investigaci\u00f3n de nuevos tratamientos contra el edema cerebral\" \/><meta itemprop=\"datePublished\" content=\"2012-03-19\" \/><meta itemprop=\"dateModified\" content=\"2023-03-02\" \/><meta itemprop=\"name\" content=\"IDIBELL\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/es\/wp-content\/uploads\/sites\/4\/2023\/03\/cropped-Marca-B.png\"\/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/es\/author\/erigin\/\" \/><meta itemprop=\"name\" content=\"Idibell\" \/><meta itemprop=\"url\" content=\"https:\/\/idibell.cat\/es\/wp-content\/uploads\/sites\/4\/2012\/03\/Clipboard-3.jpg\" \/><meta itemprop=\"width\" content=\"1366\" \/><meta itemprop=\"height\" content=\"768\" \/><meta itemprop=\"interactionType\" content=\"https:\/\/schema.org\/CommentAction\" \/><meta itemprop=\"userInteractionCount\" content=\"0\" \/>\t\n\t\t\t\t<a href=\"https:\/\/idibell.cat\/es\/2012\/03\/un-paso-mas-en-la-investigacion-de-nuevos-tratamientos-contra-el-edema-cerebral\/\" title=\"Un paso m\u00e1s en la investigaci\u00f3n de nuevos tratamientos contra el edema cerebral\"><\/a>\n\t\t\t<a href=\"https:\/\/idibell.cat\/es\/2012\/03\/un-paso-mas-en-la-investigacion-de-nuevos-tratamientos-contra-el-edema-cerebral\/\" title=\"Un paso m\u00e1s en la investigaci\u00f3n de nuevos tratamientos contra el edema cerebral\">Un paso m\u00e1s en la investigaci\u00f3n de nuevos tratamientos contra el edema cerebral<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/es\/author\/erigin\/\">Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t19\/03\/2012\t\t\t\t\t\t\t\n\t\t<!-- .pp-content-posts -->\n\n","protected":false},"excerpt":{"rendered":"<p>Fisiolog\u00eda y patolog\u00eda de la relaci\u00f3n funcional glia-neurona Resumen El cloruro es el ani\u00f3n m\u00e1s abundante en organismos. Los canales de cloro de membrana plasm\u00e1ticos de la familia CLC i LRRC8 son importantes para varias funciones fisiol\u00f3gicas, como la regulaci\u00f3n de la excitabilidad a las c\u00e9lulas nerviosas y el m\u00fasculo, tanto para la regulaci\u00f3n del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":552,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-2669","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2024-12-29 12:42:47","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/2669","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=2669"}],"version-history":[{"count":7,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/2669\/revisions"}],"predecessor-version":[{"id":24640,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/2669\/revisions\/24640"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/552"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=2669"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}