{"id":2605,"date":"2019-10-06T23:36:11","date_gmt":"2019-10-06T21:36:11","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2605"},"modified":"2024-06-27T15:55:10","modified_gmt":"2024-06-27T13:55:10","slug":"senalizacion-celular-y-biologia-del-hueso","status":"publish","type":"page","link":"https:\/\/idibell.cat\/es\/investigacion\/area-de-medicina-traslacional\/programa-de-diabetes-y-metabolismo\/senalizacion-celular-y-biologia-del-hueso\/","title":{"rendered":"Se\u00f1alizaci\u00f3n Celular y Biolog\u00eda del Hueso"},"content":{"rendered":"\n
Relevancia fisiol\u00f3gica y patol\u00f3gica de las ubicuitina ligasas HERC en inflamaci\u00f3n, diferenciaci\u00f3n y carcinog\u00e9nesis.<\/p>\n
2. Fisopatolog\u00eda \u00f3sea, regeneraci\u00f3n \u00f3sea y osteointegraci\u00f3n (Francesc Ventura)<\/p>\n
Fisiopatolog\u00eda \u00f3sea, regeneraci\u00f3n \u00f3sea y osteointegraci\u00f3n: Reprogramaci\u00f3n metab\u00f3lica en el desarrollo \u00f3seo.<\/p>\n
Fisiopatolog\u00eda y alternativas terap\u00e9uticas para el tratamiento de la fibrodisplasia osificante progresiva (FOP).<\/p>\n
C\u00e9lulas madre y generaci\u00f3n de andamios como estrategia terap\u00e9utica para la ingenier\u00eda de tejido \u00f3seo.<\/p>\n\t\t\t\t\tPublicaciones seleccionadas<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t Se\u00f1alizaci\u00f3n celular y biolog\u00eda del hueso Resumen Nuestro objetivo es comprender las v\u00edas de se\u00f1alizaci\u00f3n involucradas en la comunicaci\u00f3n celular. Nos centramos en c\u00f3mo las alteraciones en la se\u00f1alizaci\u00f3n pueden alterar el metabolismo, la fisiopatolog\u00eda y la regeneraci\u00f3n \u00f3sea, con el objetivo de encontrar nuevas terapias mediante la modificaci\u00f3n de estas v\u00edas. Este grupo es […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":540,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-2605","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2025-04-10 22:52:29","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/2605","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=2605"}],"version-history":[{"count":9,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/2605\/revisions"}],"predecessor-version":[{"id":24688,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/2605\/revisions\/24688"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/540"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=2605"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}\n
\nLa ubicuitina ligasa HERC2 es esencial para el desarrrollo embrionario y regula la coordinaci\u00f3n motora.
\nLa funci\u00f3n de p38 i PI3K es necesaria para el desarrollo i home\u00f3stasis \u00f3sea.
\nTratamiento combinado con BMP i Wnt mejora la regeneraci\u00f3n tisular \u00f3sea a partir de c\u00e9lulas madre mesenquimales.\n\t\t\t\t\n
\n\t\tVentura Pujol, Francesc\n\t<\/h4>\n
\n\t\t\n\t\tfventura@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tInvestigadores principales\n\t<\/h2>\n\t\t\t\t
\n
\n\t\tVentura Pujol, Francesc\n\t<\/h4>\n
\n\t\t\n\t\tfventura@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t
\n
\n\t\tRosa L\u00f3pez, Jos\u00e9 Luis\n\t<\/h4>\n
\n\t\t\n\t\tjlrosa@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t
\n
\n\t\tManzanares C\u00e9spedes, Cristina\n\t<\/h4>\n
\n\t\t\n\t\tcmanzanares@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tEquipo\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tJefes\/as de grupo\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as principales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as postdoctorales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as predoctorales\t\t\t\t<\/a>\n\t\t\t\t\t\tJefes\/as de grupo\n\t\t\t\t\t\t\t\t\t\t\t
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\n\t\tNoticias relacionadas\n\t<\/h2>\n\t\t\n\t\t\t\t<\/a>\n\t\t\tInvestigadores del IDIBELL y la UB encuentran que la deficiencia de la prote\u00edna HERC1 provoca osteopenia<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t03\/03\/2023\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tNuevas claves moleculares sobre un trastorno del neurodesarrollo con similitudes con s\u00edndrome de Angelman<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t15\/11\/2022\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tDescubren un mecanismo esencial para el mantenimiento de la densidad \u00f3sea<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t10\/12\/2021\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tNuevos descubrimientos sobre la funci\u00f3n supresora de tumores de las prote\u00ednas HERC<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t20\/02\/2020\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tInvestigadores del IDIBELL y la Universidad de Barcelona describen un nuevo tratamiento que podr\u00eda hacer frente a dos enfermedades \u00f3seas<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t02\/08\/2019\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tDescriben nuevo regulador de la actividad de una prote\u00edna inactiva en m\u00e1s del 50% de los tumores en humanos<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t21\/07\/2014\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tUna mutaci\u00f3n gen\u00e9tica causa un retraso mental muy similar al del s\u00edndrome de Angelman en individuos de la comunidad Amish<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t12\/03\/2013\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa Marat\u00f3 de TV3 financia cuatro proyectos de investigadores del IDIBELL<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t06\/11\/2012\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tInvestigadores del IDIBELL y de la UB identifican un gen que causa problemas de movimiento en ratones<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t12\/01\/2010\t\t\t\t\t\t\t\n\t\t\n\n","protected":false},"excerpt":{"rendered":"