{"id":25418,"date":"2025-01-09T10:41:07","date_gmt":"2025-01-09T09:41:07","guid":{"rendered":"https:\/\/idibell.cat\/es\/?page_id=25418"},"modified":"2025-03-17T10:22:06","modified_gmt":"2025-03-17T09:22:06","slug":"cancer-pancreatico","status":"publish","type":"page","link":"https:\/\/idibell.cat\/es\/investigacion\/area-de-cancer\/programa-de-mecanismos-moleculares-y-terapia-experimental-en-oncologia-oncobell\/cancer-pancreatico\/","title":{"rendered":"C\u00e1ncer pancre\u00e1tico"},"content":{"rendered":"\n<h1>\n\t\tC\u00e1ncer pancre\u00e1tico\n\t<\/h1>\n<h3>\n\t\tResumen\n\t<\/h3>\n\t<p>Nuestro laboratorio se centra en comprender c\u00f3mo se regula la heterogeneidad de los pacientes con PDAC y c\u00f3mo las complejas interacciones con y dentro del microambiente tumoral afectan el resultado de la enfermedad y la respuesta al tratamiento. Para abordar estas cuestiones, mantenemos colaboraciones activas con socios cl\u00ednicos y utilizamos modelos humanos primarios in vitro e in vivo, tecnolog\u00edas \u00f3micas de \u00faltima generaci\u00f3n y an\u00e1lisis bioinform\u00e1ticos de datos de pacientes p\u00fablicos y autogenerados. Nuestro grupo tiene como objetivo comprender los tumores de c\u00e1ncer de p\u00e1ncreas en su conjunto con el objetivo de definir nuevas terapias que se traduzcan en un beneficio mensurable en los pacientes con PDAC.<\/p>\n<h2>29<\/h2>\n<h2>Publicaciones<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/es\/wp-content\/uploads\/sites\/4\/2025\/01\/Pancreatic-Cancer.jpg\" alt=\"Pancreatic-Cancer\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"Pancreatic-Cancer\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">L\u00edneas estrat\u00e9gicas<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>El papel multifac\u00e9tico de los fibroblastos asociados al c\u00e1ncer en la promoci\u00f3n de la agresividad del c\u00e1ncer de p\u00e1ncreas<\/li>\n<li>La v\u00eda de gu\u00eda axonal determina el microambiente inmunosupresor del <strong>c\u00e1ncer de p\u00e1ncreas<\/strong><\/li>\n<li>Los modelos multicelulares SMART in vitro y los explantes derivados de pacientes como plataformas para el estudio de la medicina personalizada del c\u00e1ncer de p\u00e1ncreas.<\/li>\n<li>El impacto de la c\u00e9lula de origen en la patobiolog\u00eda y la gesti\u00f3n cl\u00ednica del adenocarcinoma ductal de p\u00e1ncreas<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Publicaciones seleccionadas<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Pe\u00f1uelas-Haro I, Espinet E#. <strong>A novel empeROR of pancreatic malignancy<\/strong>. EMBO Journal. 2023 Jul 17;42(14):e114282. doi: 10.15252\/embj.2023114282<\/li>\n<li>Espinet E, Klein L, Pure E, Singh SK. <strong>Mechanisms of PDAC subtype heterogeneity and therapy response. <\/strong>Trends in Cancer. 2022 Dec;8(12):1060-1071. doi: 10.1016\/j.trecan.2022.08.005<\/li>\n<li>Wiedmann L*, De Angelis Rigotti F*, Vaquero-Siguero N, Donato E, Espinet E, Moll I, Alsina-Sanchis E, Bohnenberger H, Fernandez-Florido E, M\u00fclfarth R, Vacca M, Gerwing J, Conradi LC, Str\u00f6bel P, Trumpp A, Mogler C, Fischer A#, Rodriguez-Vita J#. <strong>HAPLN1 is a driver for peritoneal carcinomatosis in pancreatic cancer<\/strong>. Nature Communications. 2023 Apr 24;14(1):2353. doi: 10.1038\/s41467-023-38064-w.<\/li>\n<li>Liffers SV*, Godfrey L*, Frohn L, Haeberle L, Yavas A, Vesce R, Goering W, Opitz FV, Stoecklein N, Knoefel WT, Schlitter AM, Kl\u00f6ppel G, Espinet E, Trumpp A, Siveke JT, Esposito I. <strong>Molecular heterogeneity and commonalities in pancreatic cancer precursors with gastric and intestinal phenotype. <\/strong>Gut. 2023 Mar;72(3):522-534. doi: 10.1136\/gutjnl-2021-326550<\/li>\n<li>Krebs N*, Klein L*, Wegwitz F, Espinet E, Maurer HC, Tu M, Penz F, K\u00fcffer S, Xu X, Bohnenberger H, Cameron S, Brunner M, Neesse A, Kishore U, Hessmann E, Trumpp T, Str\u00f6bel P, Brekken RA, Ellenrieder V, Singh SK. <strong>Axon Guidance Receptor ROBO3 Establishes Basal-like Phenotypic State and Therapeutic Vulnerabilities in Pancreatic Cancer. <\/strong>JCI Insight.2022 Aug 22;7(16):e154475. doi: 10.1172\/jci.insight.154475.<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Proyectos seleccionados<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"-1\"><i title=\"Expand\">Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>La Caixa Foundation. The cell of origin of Pancreatic Cancer: novel opportunities for the early diagnosis and treatment. Joint proposal, 4 PIs from Spain and Portugal. <strong>PL.<\/strong> 319.540\u20ac individual budget (total joint funding budget 1M\u20ac).<\/li>\n<li><strong>TRANSCAN-3<\/strong>. Targeting ROBOs and SLIT guidance cues in the immune-suppressive stromal context of pancreatic cancer (TRanSLIT). Joint proposal, 6 PIs from transnational groups (France, Italy, Belgium, Germany). ERA-NET.<strong> PI.<\/strong> 302.600\u20ac individual budget (total joint funding budget 1.464.400\u20ac). 2022-2025.<\/li>\n<li>PID2021-124520OA-I00. <strong>Proyectos de Generaci\u00f3n de Conocimiento<\/strong>. Interferon signaling activation of the Pancreatic Ductal AdenoCarcinoma stroma (InterferONinPDAC). Spanish Ministry for Science and Innovation. PI. 193.600\u20ac. 2022-2025.<\/li>\n<li><strong>SGR-Cat2021.<\/strong> C\u00e0ncer de la Dona. Generalitat de Catalunya &#8211; AGAUR. <strong>Co-PI.<\/strong> Leading applicant: Ruth Rodriguez Barrueco. 40.000\u20ac. 2023-2025.<br \/>\nRYC-2020- 029767-I. <strong>Ram\u00f3n y Cajal contract.<\/strong> Spanish Ministry for Science and Innovation.<strong> PI.<\/strong> 324.250\u20ac. 2022-2027.<\/li>\n<\/ul>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/es\/wp-content\/uploads\/sites\/4\/2022\/06\/Elisa-Espinet-150x150.jpg\" alt=\"Elisa-Espinet\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Elisa-Espinet\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tEspinet Hern\u00e1ndez, Elisa\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:eespinet@idibell.cat\" title=\"eespinet@idibell.cat\"  target=\"_blank\"  rel=\"noopener\">\n\t\teespinet@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tInvestigadores principales\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/es\/wp-content\/uploads\/sites\/4\/2022\/06\/Elisa-Espinet-150x150.jpg\" alt=\"Elisa-Espinet\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Elisa-Espinet\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tEspinet Hern\u00e1ndez, Elisa\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:eespinet@idibell.cat\" title=\"eespinet@idibell.cat\"  target=\"_blank\"  rel=\"noopener\">\n\t\teespinet@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/es\/wp-content\/uploads\/sites\/4\/2019\/09\/laquente-saez-berta-150x150.jpg\" alt=\"laquente-saez-berta\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"laquente-saez-berta\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tLaquente S\u00e1ez, Berta\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:blaquente@idibell.cat\" title=\"blaquente@idibell.cat\"  target=\"_blank\"  rel=\"noopener\">\n\t\tblaquente@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\tENLACES RELACIONADOS\n\t<\/h4>\n\t\t\t\t<a href=\"https:\/\/pancreaticcancerlab.ub.edu\/\"  target=\"_blank\" rel=\"noopener\"  itemprop=\"url\">\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/es\/wp-content\/uploads\/sites\/4\/2025\/01\/pancreaticcancerlab_color_-150x150.png\" alt=\"pancreaticcancerlab_color_\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"pancreaticcancerlab_color_\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t<\/a>\n<h4>\n\t\t<a href=\"https:\/\/alipanc.org\/grupo\/laboratorio-cancer-pancreas\/\" title=\"ALIPANC\"  target=\"_blank\"  rel=\"noopener\">\n\t\tALIPANC\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/transpan.eu\/\" title=\"TRANSPAN COST action\"  target=\"_blank\"  rel=\"noopener\">\n\t\tTRANSPAN COST action \n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tEquipo\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tJefes\/as de grupo\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadores\/as principales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadores\/as postdoctorales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadores\/as predoctorales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-4\" data-index=\"4\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-4\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tSoporte cientifico \t\t\t\t<\/a>\n\t\t\t\t\t\tJefes\/as de grupo\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Espinet Hern\u00e1ndez, Elisa<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadores\/as principales\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Laquente S\u00e1ez, Berta<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadores\/as postdoctorales\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Pe\u00f1uelas Haro, Irene<\/li>\n<li>Pel\u00e1ez Llaneza, Nicol\u00e1s<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadores\/as predoctorales\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Jimenez Arriola, Martin<\/li>\n<li>Acu\u00f1a Pincay, Cristhian Ariel<\/li>\n<\/ul>\n\t\t\t\t\t\tSoporte cientifico \n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Venga Mendez, Anton<\/li>\n<\/ul>\n<h2>\n\t\tNoticias relacionadas\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/23853\" content=\"El IDIBELL celebra con \u00e9xito la 7\u00aa edici\u00f3n del sLHam de cient\u00edficas\" \/><meta itemprop=\"datePublished\" content=\"2024-02-11\" \/><meta 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href=\"https:\/\/idibell.cat\/es\/2023\/03\/la-asociacion-contra-el-cancer-en-barcelona-subvenciona-cuatro-proyectos-del-idibell-con-casi-500-000-euros\/\" title=\"La Asociaci\u00f3n Contra el C\u00e1ncer en Barcelona subvenciona cuatro proyectos del IDIBELL con casi 500.000 euros\">La Asociaci\u00f3n Contra el C\u00e1ncer en Barcelona subvenciona cuatro proyectos del IDIBELL con casi 500.000 euros<\/a>\n\t\t\tBy <a href=\"https:\/\/idibell.cat\/es\/author\/comunicacio\/\">comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t  |  \n\t\t\t\t\t\t\t\t\t14\/03\/2023\t\t\t\t\t\t\t\n\t\t<!-- .pp-content-posts -->\n\n","protected":false},"excerpt":{"rendered":"<p>C\u00e1ncer pancre\u00e1tico Resumen Nuestro laboratorio se centra en comprender c\u00f3mo se regula la heterogeneidad de los pacientes con PDAC y c\u00f3mo las complejas interacciones con y dentro del microambiente tumoral afectan el resultado de la enfermedad y la respuesta al tratamiento. Para abordar estas cuestiones, mantenemos colaboraciones activas con socios cl\u00ednicos y utilizamos modelos humanos [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"unboxed","site-sidebar-style":"unboxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-25418","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2025-04-09 21:50:46","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/25418","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=25418"}],"version-history":[{"count":18,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/25418\/revisions"}],"predecessor-version":[{"id":25815,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/25418\/revisions\/25815"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/448"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=25418"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}