{"id":2137,"date":"2019-10-02T00:58:47","date_gmt":"2019-10-01T22:58:47","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=2137"},"modified":"2024-01-11T08:50:11","modified_gmt":"2024-01-11T07:50:11","slug":"bases-celulares-y-moleculares-de-los-trastornos-sensoriales","status":"publish","type":"page","link":"https:\/\/idibell.cat\/es\/investigacion\/area-de-neurociencias\/programa-de-neurociencias\/bases-celulares-y-moleculares-de-los-trastornos-sensoriales\/","title":{"rendered":"Bases Celulares y Moleculares de los Trastornos Sensoriales"},"content":{"rendered":"\n
El grupo afronta los retos de curar los trastornos sensoriales y preservar las funciones sensoriales durante el envejecimiento mediante el estudio de modelos animales originales en sistema vestibular y retina. El grupo desarrolla modelos que permiten la obtenci\u00f3n de informaci\u00f3n con relevancia terap\u00e9utica sobre estos sistemas sensoriales tan complejos gracias a la utilizaci\u00f3n de metodolog\u00edas de primera l\u00ednea, como la microscopia de fluorescencia de super-resoluci\u00f3n, el RNA-seq, o la prote\u00f3mica.<\/p>\n
Barrallo Gimeno A, Llorens J. Hair cell toxicology: With the help of a little fish<\/strong>. Front. Cell. Dev. Biol. 2022;10doi:10.3389\/fcell.2022.1085225.<\/p>\n Garg G, Finger PT, Kivel\u00e4 TT, Simpson ER, Gallie BL, Saakyan S, Amiryan AG, Valskiy V, Chin KJ, Semenova E, Seregard S, Fil\u00ec M, Wilson M, Haik B, Caminal JM, Catala Mora J, Guti\u00e9rrez C, Pelayes DE, Folgar AM, Jager MJ, Dogrus\u00f6z M, Luyten GPM, Singh AD, Suzuki S, AJCC Ophthalmic Oncology Task F. Patients presenting with metastases: stage IV uveal melanoma, an international study<\/strong>. Br J Ophthalmol. 2022;106(4):510-517. doi:10.1136\/bjophthalmol-2020-317949.<\/p>\n Caminal JM, Lorenzo D, Gutierrez C, Slocker A, Piulats JM, Cobos E, Garcia Bru P, Morwani R, Santamaria JF, Arias L. Local Resection in Choroidal Melanoma: A Review<\/strong>. J. Clin. Med. 2022;11(23):doi:10.3390\/jcm11237156.<\/p>\n Garcia Tornel A, Millan M, Rubiera M, Bustamante A, Requena M, Dorado L, Oliv\u00e9 Gadea M, Jim\u00e9nez X, Soto A, Querol M, Hern\u00e1ndez P\u00e9rez M, Gomis M, Cardona P, Urra X, Purroy F, Silva Y, Ustrell X, Esteve P, Salvat Plana M, Gallofr\u00e9 M, Molina C, D\u00e1valos A, Jovin T, Abilleira S, Ribo M, P\u00e9rez de la Ossa N, RACECAT Trial I. Workflows and Outcomes in Patients With Suspected Large Vessel Occlusion Stroke Triaged in Urban and Nonurban Areas<\/strong>. Stroke. 2022;doi:10.1161\/STROKEAHA.122.040768.<\/p>\n Gabrielle PH, Nguyen V, Arnould L, Viola F, Zarranz Ventura J, Barthelmes D, Creuzot Garcher C, Gillies M, Fight Retinal Blindness! Study G. Incidence, Risk Factors, and Outcomes of Rhegmatogenous Retinal Detachment after Intravitreal Injections of Anti-VEGF for Retinal Diseases: Data from the Fight Retinal Blindness! Registry<\/strong>. Ophthalmol Retina. 2022;6(11):1044-1053. doi:10.1016\/j.oret.2022.05.008.<\/p>\n\t\t\t\t\tProyectos seleccionados<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t PUB22015. Aplicaci\u00f3 de noves tecnologies moleculars en el diagn\u00f2stic gen\u00e8tic de les distr\u00f2fies heredit\u00e0ries de retina<\/strong>. Hospital Universitario de Bellvitge. Budget: 20000. 2022-2025. PI: Cobos Mart\u00edn, Estefan\u00eda.<\/p>\n2022-222-1. RETROSPECTIVE CHART REVIEW STUDY COMBINED WITH CROSS-SECTIONAL PATIENT AND CAREGIVER SURVEYS TO DOCUMENT AND DESCRIBE THE DISEASE-RELATED CLINICAL, INDIVIDUAL, SOCIO-DEMOGRAPHIC CHARACTERISTICS OF PATIENTS WITH X-LINKED RETINITIS PIGMENTOSA (XLRP) AND THE IMPACT OF XLRP ON PATIENTS AND THEIR CAREGIVERS<\/strong>. PCI2020-120681-2. Vestibular loss and spatial orientation<\/strong>. ERA-NET Neuron (Agencia Estatal de Investigaci\u00f3n). Budget: 150000. 2021-2024. PI: Llorens Baucells, Jordi.<\/p>\n PID2021-124678OB-I00. New molecular mechanisms in chronic vestibular damage<\/strong>. Agencia Estatal de Investigaci\u00f3n. Budget: 96800. 2022-2025. PI: Llorens Baucells, Jordi i Barrallo Gimeno, Alejandro.<\/p>\n PID2020-115431RB-I00. Retinal adaptation to light and pan-disease therapeutic targets in inherited blindness: IMPDH1 and energy metabolism<\/strong>. Agencia Estatal de Investigaci\u00f3n. Budget: 120000. 2021-2024. PI: M\u00e9ndez Zunzunegui, Ana.<\/p>\n 202007-30-31. A patient centered research: awareness of patient needs, clinical phenotyping and molecular parthenogenesis in Neurofibromatosis type 2<\/strong>. Fundaci\u00f3 La Marat\u00f3 de TV3. Budget: 142485,90. 2021-2024. PI: Llorens Baucells, Jordi.<\/p>\n\t\t\t\t\tM\u00e1s informaci\u00f3n<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\tIdentificaci\u00f3n de nitrilos como nueva familia de compuestos con toxicidad vestibular. Bases Celulares y Moleculares de los Trastornos Sensoriales Resumen El grupo afronta los retos de curar los trastornos sensoriales y preservar las funciones sensoriales durante el envejecimiento mediante el estudio de modelos animales originales en sistema vestibular y retina. El grupo desarrolla modelos que permiten la obtenci\u00f3n de informaci\u00f3n con relevancia terap\u00e9utica sobre estos sistemas […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":503,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"publishpress_future_action":{"enabled":false,"date":"2024-05-07 14:35:56","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/2137"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=2137"}],"version-history":[{"count":5,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/2137\/revisions"}],"predecessor-version":[{"id":23678,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/2137\/revisions\/23678"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/503"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=2137"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n(EXPLORE XLRP 2 ). Budget: 7850. 2022- . PI: Cobos Mart\u00edn, Estefan\u00eda.\n
\nModelos animales de base para la ablaci\u00f3n de c\u00e9lulas capilares en el sistema vestibular del rat\u00f3n.
\nIdentificaci\u00f3n del desacoplamiento sin\u00e1ptico y extrusi\u00f3n de c\u00e9lulas capilares como principales acontecimientos en la toxicidad vestibular cr\u00f3nica.
\nCaracterizaci\u00f3n del papel de las prote\u00ednas GCAP en las respuestas ligeras.
\nIdentificaci\u00f3n de GCAP2 como mediador de da\u00f1os ligeros, involucrados en la fisiopatolog\u00eda de los trastornos gen\u00e9ticos \u00abligeros\u00bb.\n\t\t\t\t\n\n\t\tLlorens Baucells, Jordi\n\t<\/h4>\n
\n\t\t\n\t\tjllorens@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tInvestigadores principales\n\t<\/h2>\n\t\t\t\t\n
\n\t\tLlorens Baucells, Jordi\n\t<\/h4>\n
\n\t\t\n\t\tjllorens@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tMendez Zunzunegui, Ana\n\t<\/h4>\n
\n\t\t\n\t\tmendezzu@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tBarrallo Gimeno, Alejandro\n\t<\/h4>\n
\n\t\t\n\t\tabarrallo@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tCatala Mora, Jaume \n\t<\/h4>\n
\n\t\tENLACES RELACIONADOS\n\t<\/h4>\n
\n\t\t\n\t\tInstituto de Neurociencias UB\n\t\t<\/a>\n\t<\/h4>\n
\n\t\t\n\t\t@UBneuroscience\n\t\t<\/a>\n\t<\/h4>\n
\n\t\t\n\t\t@JordiLlorensUB\n\t\t<\/a>\n\t<\/h4>\n
\n\t\t\n\t\t@alexbarrallo\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tEquipo\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tJefes\/as de grupo\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as principales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as cl\u00ednico\/as\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as postdoctorales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as predoctorales\t\t\t\t<\/a>\n\t\t\t\t\t\tJefes\/as de grupo\n\t\t\t\t\t\t\t\t\t\t\t
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\n\t\tNoticias relacionadas\n\t<\/h2>\n\t\t\n\t\t\t\t<\/a>\n\t\t\tDescriben las v\u00edas de regulaci\u00f3n de un enzima clave en la excitaci\u00f3n de las c\u00e9lulas fotorreceptoras de la retina<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t24\/04\/2020\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tEncuentran la prote\u00edna responsable de la muerte celular causante de un tipo de ceguera<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t13\/02\/2020\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tDeterminan las causas moleculares de la recuperaci\u00f3n del sentido del equilibrio en casos de ototoxicidad<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t06\/10\/2015\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa ONCE y el IDIBELL colaboran en un proyecto sobre ceguera hereditaria<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t19\/03\/2015\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa Fundaci\u00f3n Ram\u00f3n Areces financia un proyecto sobre ceguera hereditaria del IDIBELL<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t09\/02\/2015\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tDescriben un mecanismo relevante en ciertos tipos de ceguera hereditaria<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t25\/07\/2014\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa ONCE y el IDIBELL colaboran en un proyecto sobre ceguera hereditaria<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t05\/03\/2014\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa intoxicaci\u00f3n por compuestos industriales puede provocar efectos similares a la ELA<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t17\/07\/2012\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tJordi Llorens nombrado presidente de la Internacional Neurotoxicology Association<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t20\/06\/2011\t\t\t\t\t\t\t\n\t\t\n\n","protected":false},"excerpt":{"rendered":"