{"id":1865,"date":"2019-09-26T13:10:14","date_gmt":"2019-09-26T11:10:14","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=1865"},"modified":"2025-04-09T16:06:06","modified_gmt":"2025-04-09T14:06:06","slug":"metabolismo-del-cancer","status":"publish","type":"page","link":"https:\/\/idibell.cat\/es\/investigacion\/area-de-cancer\/programa-de-mecanismos-moleculares-y-terapia-experimental-en-oncologia-oncobell\/metabolismo-del-cancer\/","title":{"rendered":"Metabolismo del c\u00e1ncer"},"content":{"rendered":"\n
El grupo de Metabolismo y C\u00e1ncer incluye a los doctores George Thomas, Sara Kozma, Albert Tauler y Antonio Gentilella. El programa se centra en la se\u00f1alizaci\u00f3n de quinasas del complejo 1 de la diana de Rapamicina (mTORC1) en c\u00e9lulas de mam\u00edferos y sus principales respuestas metab\u00f3licas en cascada, incluida la biog\u00e9nesis de los ribosomas, el control de la traslaci\u00f3n, la reprogramaci\u00f3n metab\u00f3lica, la autofagia, el transporte lisos\u00f3mico y la proliferaci\u00f3n celular. El objetivo del grupo es revelar vulnerabilidades metab\u00f3licas en el c\u00e1ncer para promover nuevos tratamientos cl\u00ednicos, utilizando el c\u00e1ncer colorrectal (CCR) y otros modelos tumorales impulsados \u200b\u200bpor c-MYC e interactuando con onc\u00f3logos y compa\u00f1\u00edas farmac\u00e9uticas.<\/p>\n
Lluch A, Veiga SR, Latorre J, Moreno Navarrete JM, Bonifaci N, Nguyen VD, Zhou Y, Horing M, Liebisch G, Olkkonen VM, Llobet Navas D, Thomas G, Rodriguez Barrueco R, Fern\u00e1ndez Real JM, Kozma SC, Ortega FJ. A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis<\/strong>. JCI Insight. 2022;7(14):doi:10.1172\/jci.insight.150461.<\/p>\n Almacellas E, Garcia Cajide M, Tauler A, Mauvezin C. Analysis of Autophagic Vesicles in Mitotic Cells<\/strong>. Methods Mol Biol. 2022;2445127-137. doi:10.1007\/978-1-0716-2071-7_9.<\/p>\n Pons C, Almacellas E, Tauler A, Mauvezin C. Detection of Nuclear Biomarkers for Chromosomal Instability<\/strong>. Methods Mol Biol. 2022;2445117-125. doi:10.1007\/978-1-0716-2071-7_8.<\/p>\nDomostegui A, Peddigari S, Mercer CA, Iannizzotto F, Rodriguez ML, Garcia Cajide M, Amador V, Diepstraten ST, Kelly GL, Salazar R, Kozma SC, Kusnadi EP, Kang J, Gentilella A, Pearson RB, Thomas G, Pelletier J. Almacellas E, Pelletier J, Day C, Ambrosio S, Tauler A, Mauvezin C. Lysosomal degradation ensures accurate chromosomal segregation to prevent chromosomal instability<\/strong>. Autophagy. 2021;17(3):796-813. doi:10.1080\/15548627.2020.1764727.<\/p>\n <\/p>\n <\/p>\n\n\t\t\t\t\tProyectos aseleccionados<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t Metabolismo del c\u00e1ncer Resumen El grupo de Metabolismo y C\u00e1ncer incluye a los doctores George Thomas, Sara Kozma, Albert Tauler y Antonio Gentilella. El programa se centra en la se\u00f1alizaci\u00f3n de quinasas del complejo 1 de la diana de Rapamicina (mTORC1) en c\u00e9lulas de mam\u00edferos y sus principales respuestas metab\u00f3licas en cascada, incluida la biog\u00e9nesis […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"unboxed","site-sidebar-style":"unboxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-1865","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2025-05-20 11:42:46","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/1865","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=1865"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/1865\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/448"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=1865"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nImpaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death<\/strong>. Blood. 2021;137(24):3351-3364. doi:10.1182\/blood.2020007452.\n\n
\nEl Dr. Tauler ha trabajado extensamente en la v\u00eda glicol\u00edtica y su control por se\u00f1ales mitog\u00e9nicos. Algunos de sus trabajos sobre la bi-funcionalidad PF2K forman parte de los principales libros de texto de Bioqu\u00edmica.\n\t\t\t\t\n
\n\t\tGentilella, Antonio\n\t<\/h4>\n
\n\t\t\n\t\tagentilella@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tInvestigadores principales\n\t<\/h2>\n\t\t\t\t
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\n\t\tGentilella, Antonio\n\t<\/h4>\n
\n\t\t\n\t\tagentilella@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t
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\n\t\tTauler Girona, Albert\n\t<\/h4>\n
\n\t\t\n\t\tatauler@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t
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\n\t\tPelletier, Joffrey\n\t<\/h4>\n
\n\t\t\n\t\tjpelletier@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tENLACES RELACIONADOS\n\t<\/h4>\n
\n\t\t\n\t\t@A_Gentilella\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tEquipo\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tJefes\/as de grupo\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as principales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as postdoctorales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as predoctorales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tSoporte cient\u00edfico\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tEstudiantes\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as em\u00e9ritos\/as\t\t\t\t<\/a>\n\t\t\t\t\t\tJefes\/as de grupo\n\t\t\t\t\t\t\t\t\t\t\t
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\n\t\tNoticias relacionadas\n\t<\/h2>\n\t\t\n\t\t\t\t<\/a>\n\t\t\tCrean dos nuevas herramientas de edici\u00f3n gen\u00e9tica a partir de microorganismos del fondo del oc\u00e9ano: la CRISPR de Ast\u00e9rix y Ob\u00e9lix<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t03\/04\/2025\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa Dra. Roser Velasco, coautora principal de una gu\u00eda internacional sobre manejo de complicaciones neurol\u00f3gicas en tratamientos con c\u00e9lulas CAR-T<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t02\/04\/2025\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa terapia g\u00e9nica revierte en modelos animales la sintomatolog\u00eda de una enfermedad neurol\u00f3gica minoritaria<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t31\/03\/2025\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tUn estudio multic\u00e9ntrico alerta sobre el aumento de infecciones graves por Streptococcus dysgalactiae en Espa\u00f1a<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t24\/03\/2025\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIDIBELL acerca la neurociencia a la ciudadan\u00eda en el marco de la Semana del Cerebro en L’Hospitalet<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t14\/03\/2025\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIDIBELL y el Ayuntamiento de L’Hospitalet firman un convenio de colaboraci\u00f3n para promover la divulgaci\u00f3n cient\u00edfica<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t13\/03\/2025\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tDescubren el papel clave de los macr\u00f3fagos en la regeneraci\u00f3n intestinal tras la radioterapia y la enfermedad inflamatoria intestinal<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t12\/03\/2025\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tPresencia de profesionales del IDIBELL y el HUB en el nuevo ranking de mujeres investigadoras del CSIC<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t07\/03\/2025\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLas altas temperaturas podr\u00edan afectar a la funci\u00f3n cerebral en preadolescentes<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t06\/03\/2025\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tTres proyectos de investigaci\u00f3n en VPH reciben 1.7M de euros para mejorar la prevenci\u00f3n y el tratamiento de la infecci\u00f3n<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t05\/03\/2025\t\t\t\t\t\t\t\n\t\t\n\n","protected":false},"excerpt":{"rendered":"