{"id":1865,"date":"2019-09-26T13:10:14","date_gmt":"2019-09-26T11:10:14","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=1865"},"modified":"2024-10-03T15:07:22","modified_gmt":"2024-10-03T13:07:22","slug":"metabolismo-y-cancer","status":"publish","type":"page","link":"https:\/\/idibell.cat\/es\/investigacion\/area-de-cancer\/programa-de-mecanismos-moleculares-y-terapia-experimental-en-oncologia-oncobell\/metabolismo-y-cancer\/","title":{"rendered":"Metabolismo y C\u00e1ncer"},"content":{"rendered":"\n
El grupo de Metabolismo y C\u00e1ncer incluye a los doctores George Thomas, Sara Kozma, Albert Tauler y Antonio Gentilella. El programa se centra en la se\u00f1alizaci\u00f3n de quinasas del complejo 1 de la diana de Rapamicina (mTORC1) en c\u00e9lulas de mam\u00edferos y sus principales respuestas metab\u00f3licas en cascada, incluida la biog\u00e9nesis de los ribosomas, el control de la traslaci\u00f3n, la reprogramaci\u00f3n metab\u00f3lica, la autofagia, el transporte lisos\u00f3mico y la proliferaci\u00f3n celular. El objetivo del grupo es revelar vulnerabilidades metab\u00f3licas en el c\u00e1ncer para promover nuevos tratamientos cl\u00ednicos, utilizando el c\u00e1ncer colorrectal (CCR) y otros modelos tumorales impulsados \u200b\u200bpor c-MYC e interactuando con onc\u00f3logos y compa\u00f1\u00edas farmac\u00e9uticas.<\/p>\n
Lluch A, Veiga SR, Latorre J, Moreno Navarrete JM, Bonifaci N, Nguyen VD, Zhou Y, Horing M, Liebisch G, Olkkonen VM, Llobet Navas D, Thomas G, Rodriguez Barrueco R, Fern\u00e1ndez Real JM, Kozma SC, Ortega FJ. A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis<\/strong>. JCI Insight. 2022;7(14):doi:10.1172\/jci.insight.150461.<\/p>\n Almacellas E, Garcia Cajide M, Tauler A, Mauvezin C. Analysis of Autophagic Vesicles in Mitotic Cells<\/strong>. Methods Mol Biol. 2022;2445127-137. doi:10.1007\/978-1-0716-2071-7_9.<\/p>\n Pons C, Almacellas E, Tauler A, Mauvezin C. Detection of Nuclear Biomarkers for Chromosomal Instability<\/strong>. Methods Mol Biol. 2022;2445117-125. doi:10.1007\/978-1-0716-2071-7_8.<\/p>\nDomostegui A, Peddigari S, Mercer CA, Iannizzotto F, Rodriguez ML, Garcia Cajide M, Amador V, Diepstraten ST, Kelly GL, Salazar R, Kozma SC, Kusnadi EP, Kang J, Gentilella A, Pearson RB, Thomas G, Pelletier J. Almacellas E, Pelletier J, Day C, Ambrosio S, Tauler A, Mauvezin C. Lysosomal degradation ensures accurate chromosomal segregation to prevent chromosomal instability<\/strong>. Autophagy. 2021;17(3):796-813. doi:10.1080\/15548627.2020.1764727.<\/p>\n <\/p>\n <\/p>\n\n\t\t\t\t\tProyectos aseleccionados<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t Metabolismo y c\u00e1ncer Resumen El grupo de Metabolismo y C\u00e1ncer incluye a los doctores George Thomas, Sara Kozma, Albert Tauler y Antonio Gentilella. El programa se centra en la se\u00f1alizaci\u00f3n de quinasas del complejo 1 de la diana de Rapamicina (mTORC1) en c\u00e9lulas de mam\u00edferos y sus principales respuestas metab\u00f3licas en cascada, incluida la biog\u00e9nesis […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-1865","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2024-11-25 00:39:27","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/1865","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=1865"}],"version-history":[{"count":13,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/1865\/revisions"}],"predecessor-version":[{"id":24929,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/1865\/revisions\/24929"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/448"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=1865"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nImpaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death<\/strong>. Blood. 2021;137(24):3351-3364. doi:10.1182\/blood.2020007452.\n\n
\nEl Dr. Tauler ha trabajado extensamente en la v\u00eda glicol\u00edtica y su control por se\u00f1ales mitog\u00e9nicos. Algunos de sus trabajos sobre la bi-funcionalidad PF2K forman parte de los principales libros de texto de Bioqu\u00edmica.\n\t\t\t\t\n\n\t\tThomas, George\n\t<\/h4>\n
\n\t\t\n\t\tgthomas@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tInvestigadores principales\n\t<\/h2>\n\t\t\t\t\n
\n\t\tThomas, George\n\t<\/h4>\n
\n\t\t\n\t\tgthomas@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tGentilella, Antonio\n\t<\/h4>\n
\n\t\t\n\t\tagentilella@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tTauler Girona, Albert\n\t<\/h4>\n
\n\t\t\n\t\tatauler@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tPelletier, Joffrey\n\t<\/h4>\n
\n\t\t\n\t\tjpelletier@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tENLACES RELACIONADOS\n\t<\/h4>\n
\n\t\t\n\t\t@A_Gentilella\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tEquipo\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tJefes\/as de grupo\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as principales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as postdoctorales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as predoctorales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tSoporte cient\u00edfico\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tEstudiantes\t\t\t\t<\/a>\n\t\t\t\t\t\tJefes\/as de grupo\n\t\t\t\t\t\t\t\t\t\t\t
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\n\t\tNoticias relacionadas\n\t<\/h2>\n\t\t\n\t\t\t\t<\/a>\n\t\t\tB-ACTIVE: plataforma de serious games para promover un comportamiento saludable en personas con c\u00e1ncer<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t02\/10\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tBellvitge lidera la creaci\u00f3n de una nueva herramienta m\u00e1s precisa para evaluar la toxicidad neurol\u00f3gica provocada por la quimioterapia<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t27\/09\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tUna nueva terapia personalizada a trav\u00e9s del perfil gen\u00f3mico puede mejorar la supervivencia en pacientes con c\u00e1ncer de origen desconocido<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t26\/09\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa acumulaci\u00f3n de hierro y el envejecimiento celular en la fibrosis hep\u00e1tica: nuevas perspectivas en el tratamiento<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t25\/09\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLos avances en biolog\u00eda qu\u00edmica se alimentan de la multidisciplinariedad y el trabajo en equipo<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t20\/09\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tFallece el neurocient\u00edfico Ernest Arenas<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t20\/09\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa Dra. Maria Molina, directora cient\u00edfica del IDIBELL, recibe la Medalla de Oro de la European Respiratory Society<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t09\/09\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tRelacionan por primera vez la contaminaci\u00f3n del aire ambiental con el uso de antibi\u00f3ticos<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t09\/09\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tSpadaHC, una nueva base de datos para mejorar la clasificaci\u00f3n de variantes en genes de c\u00e1ncer hereditario en la poblaci\u00f3n espa\u00f1ola<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t03\/09\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tBellvitge colidera un ensayo internacional que puede cambiar el tratamiento de la insuficiencia card\u00edaca<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t02\/09\/2024\t\t\t\t\t\t\t\n\t\t\n\n","protected":false},"excerpt":{"rendered":"