{"id":1865,"date":"2019-09-26T13:10:14","date_gmt":"2019-09-26T11:10:14","guid":{"rendered":"https:\/\/idibell.cat\/?page_id=1865"},"modified":"2024-11-18T15:35:56","modified_gmt":"2024-11-18T14:35:56","slug":"metabolismo-del-cancer","status":"publish","type":"page","link":"https:\/\/idibell.cat\/es\/investigacion\/area-de-cancer\/programa-de-mecanismos-moleculares-y-terapia-experimental-en-oncologia-oncobell\/metabolismo-del-cancer\/","title":{"rendered":"Metabolismo del c\u00e1ncer"},"content":{"rendered":"\n
El grupo de Metabolismo y C\u00e1ncer incluye a los doctores George Thomas, Sara Kozma, Albert Tauler y Antonio Gentilella. El programa se centra en la se\u00f1alizaci\u00f3n de quinasas del complejo 1 de la diana de Rapamicina (mTORC1) en c\u00e9lulas de mam\u00edferos y sus principales respuestas metab\u00f3licas en cascada, incluida la biog\u00e9nesis de los ribosomas, el control de la traslaci\u00f3n, la reprogramaci\u00f3n metab\u00f3lica, la autofagia, el transporte lisos\u00f3mico y la proliferaci\u00f3n celular. El objetivo del grupo es revelar vulnerabilidades metab\u00f3licas en el c\u00e1ncer para promover nuevos tratamientos cl\u00ednicos, utilizando el c\u00e1ncer colorrectal (CCR) y otros modelos tumorales impulsados \u200b\u200bpor c-MYC e interactuando con onc\u00f3logos y compa\u00f1\u00edas farmac\u00e9uticas.<\/p>\n
Lluch A, Veiga SR, Latorre J, Moreno Navarrete JM, Bonifaci N, Nguyen VD, Zhou Y, Horing M, Liebisch G, Olkkonen VM, Llobet Navas D, Thomas G, Rodriguez Barrueco R, Fern\u00e1ndez Real JM, Kozma SC, Ortega FJ. A compound directed against S6K1 hampers fat mass expansion and mitigates diet-induced hepatosteatosis<\/strong>. JCI Insight. 2022;7(14):doi:10.1172\/jci.insight.150461.<\/p>\n Almacellas E, Garcia Cajide M, Tauler A, Mauvezin C. Analysis of Autophagic Vesicles in Mitotic Cells<\/strong>. Methods Mol Biol. 2022;2445127-137. doi:10.1007\/978-1-0716-2071-7_9.<\/p>\n Pons C, Almacellas E, Tauler A, Mauvezin C. Detection of Nuclear Biomarkers for Chromosomal Instability<\/strong>. Methods Mol Biol. 2022;2445117-125. doi:10.1007\/978-1-0716-2071-7_8.<\/p>\nDomostegui A, Peddigari S, Mercer CA, Iannizzotto F, Rodriguez ML, Garcia Cajide M, Amador V, Diepstraten ST, Kelly GL, Salazar R, Kozma SC, Kusnadi EP, Kang J, Gentilella A, Pearson RB, Thomas G, Pelletier J. Almacellas E, Pelletier J, Day C, Ambrosio S, Tauler A, Mauvezin C. Lysosomal degradation ensures accurate chromosomal segregation to prevent chromosomal instability<\/strong>. Autophagy. 2021;17(3):796-813. doi:10.1080\/15548627.2020.1764727.<\/p>\n <\/p>\n <\/p>\n\n\t\t\t\t\tProyectos aseleccionados<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t Metabolismo del c\u00e1ncer Resumen El grupo de Metabolismo y C\u00e1ncer incluye a los doctores George Thomas, Sara Kozma, Albert Tauler y Antonio Gentilella. El programa se centra en la se\u00f1alizaci\u00f3n de quinasas del complejo 1 de la diana de Rapamicina (mTORC1) en c\u00e9lulas de mam\u00edferos y sus principales respuestas metab\u00f3licas en cascada, incluida la biog\u00e9nesis […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"unboxed","site-sidebar-style":"unboxed","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-1865","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2024-12-29 12:56:23","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/1865","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=1865"}],"version-history":[{"count":18,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/1865\/revisions"}],"predecessor-version":[{"id":25125,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/1865\/revisions\/25125"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/448"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=1865"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nImpaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death<\/strong>. Blood. 2021;137(24):3351-3364. doi:10.1182\/blood.2020007452.\n\n
\nEl Dr. Tauler ha trabajado extensamente en la v\u00eda glicol\u00edtica y su control por se\u00f1ales mitog\u00e9nicos. Algunos de sus trabajos sobre la bi-funcionalidad PF2K forman parte de los principales libros de texto de Bioqu\u00edmica.\n\t\t\t\t\n\n\t\tGentilella, Antonio\n\t<\/h4>\n
\n\t\t\n\t\tagentilella@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tInvestigadores principales\n\t<\/h2>\n\t\t\t\t\n
\n\t\tGentilella, Antonio\n\t<\/h4>\n
\n\t\t\n\t\tagentilella@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tTauler Girona, Albert\n\t<\/h4>\n
\n\t\t\n\t\tatauler@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t\n
\n\t\tPelletier, Joffrey\n\t<\/h4>\n
\n\t\t\n\t\tjpelletier@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tENLACES RELACIONADOS\n\t<\/h4>\n
\n\t\t\n\t\t@A_Gentilella\n\t\t<\/a>\n\t<\/h4>\n
\n\t\tEquipo\n\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t\t\tJefes\/as de grupo\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as principales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as postdoctorales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as predoctorales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tSoporte cient\u00edfico\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tEstudiantes\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\tInvestigadores\/as em\u00e9ritos\/as\t\t\t\t<\/a>\n\t\t\t\t\t\tJefes\/as de grupo\n\t\t\t\t\t\t\t\t\t\t\t
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\n\t\tNoticias relacionadas\n\t<\/h2>\n\t\t\n\t\t\t\t<\/a>\n\t\t\tAurora Pujol recibe financiaci\u00f3n de la convocatoria CaixaResearch de Investigaci\u00f3n en Salud 2024<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t13\/11\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIdentifican un potencial biomarcador de la progresi\u00f3n de la enfermedad de Parkinson<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t12\/11\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tSe celebra la 9\u00aa edici\u00f3n del PhD Day del IDIBELL, en esta ocasi\u00f3n centrada en la inteligencia artificial<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t11\/11\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tLa Fundaci\u00f3n Niemann-Pick dona cerca de 105.000 euros para continuar con el ensayo cl\u00ednico de un f\u00e1rmaco para detener el deterioro cognitivo de la enfermedad<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t09\/11\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tUn nuevo estudio de Bellvitge alerta sobre la p\u00e9rdida de masa \u00f3sea tras la cirug\u00eda bari\u00e1trica<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t08\/11\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tBioCl\u00faster, gamificaci\u00f3n e innovaci\u00f3n en salud: la participaci\u00f3n del IDIBELL en el Smart City Expo World Congress 2024<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t07\/11\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tEstablecer una cobertura de enfermer\u00eda segura puede evitar complicaciones con el cat\u00e9ter venoso perif\u00e9rico<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t04\/11\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIdentifican 6 regiones gen\u00e9ticas que podr\u00edan reducir el riesgo cardiovascular<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t29\/10\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tSara Calvo recibe el premio al mejor art\u00edculo de investigaci\u00f3n en salud para doctorandos en el marco de la 15a Jornada del ICS<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t25\/10\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIdentifican biomarcadores en muestras de semen que podr\u00edan reducir el sobrediagn\u00f3stico en el cribado de c\u00e1ncer de pr\u00f3stata<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t25\/10\/2024\t\t\t\t\t\t\t\n\t\t\n\n","protected":false},"excerpt":{"rendered":"