{"id":17672,"date":"2021-07-01T15:56:33","date_gmt":"2021-07-01T13:56:33","guid":{"rendered":"https:\/\/idibell.cat\/es\/?page_id=17672"},"modified":"2024-05-02T08:52:14","modified_gmt":"2024-05-02T06:52:14","slug":"inmunidad-inflamacion-y-cancer","status":"publish","type":"page","link":"https:\/\/idibell.cat\/es\/investigacion\/area-de-cancer\/programa-de-mecanismos-moleculares-y-terapia-experimental-en-oncologia-oncobell\/inmunidad-inflamacion-y-cancer\/","title":{"rendered":"Inmunidad, inflamaci\u00f3n y c\u00e1ncer"},"content":{"rendered":"\n
Nuestro grupo se centra en tres l\u00edneas de investigaci\u00f3n. Con respecto a la exonucleasa TREX2, nuestros estudios han sido pioneros en desentra\u00f1ar la expresi\u00f3n espec\u00edfica de TREX2 en los queratinocitos y su papel clave en la carcinog\u00e9nesis cut\u00e1nea y la psoriasis. Tambi\u00e9n estudiamos c\u00f3mo los factores de cromatina integran se\u00f1ales extracelulares en el n\u00facleo para regular la expresi\u00f3n g\u00e9nica y, en \u00faltima instancia, influir en el destino y el comportamiento de las c\u00e9lulas. Nuestro objetivo es comprender la din\u00e1mica de la cromatina en el c\u00e1ncer para encontrar nuevas intervenciones terap\u00e9uticas. En cuanto a los virus vaccinia oncol\u00edticos (VACV), nuestro grupo se centra en mejorar su capacidad para generar respuestas inmunes antitumorales robustas mediante la activaci\u00f3n de una muerte celular cancerosa inmunog\u00e9nica (ICD) tras la infecci\u00f3n. Adem\u00e1s, tambi\u00e9n exploramos la combinaci\u00f3n de estos agentes con otras inmunoterapias contra el c\u00e1ncer con el fin de lograr una inmunoterapia combinatoria con un potencial real para curar tumores s\u00f3lidos.<\/p>\n
Manils J, Marruecos L, Soler C. Exonucleases: Degrading DNA to Deal with Genome Damage, Cell Death, Inflammation and Cancer<\/strong>. Cells. 2022;11(14):doi:10.3390\/cells11142157.<\/p>\n Sol\u00e9 Morata N, Baenas I, Etxandi M, Granero R, Forcales SV, Gen\u00e9 M, Barrot C, G\u00f3mez Pe\u00f1a M, Mench\u00f3n JM, Ramoz N, Gorwood P, Fern\u00e1ndez Aranda F, Jim\u00e9nez Murcia S. The role of neurotrophin genes involved in the vulnerability to gambling disorder<\/strong>. Sci Rep. 2022;12(1):6925-6925. doi:10.1038\/s41598-022-10391-w.<\/p>\n L\u00f3pez-Cano M, Filgaira I, Nolen EG, Cabr\u00e9 G, Hernando J, Tosh DK, Jacobson KA*, Soler C*, Ciruela F*. Optical control of adenosine A3 receptor in psoriasis.<\/strong> Pharmacological Research 2021; 170:105731.<\/p>\n Riederer S, Fux R, Lehmann MH, Volz A, Sutter G, Rojas JJ. Activation of interferon regulatory factor 3 by replication-competent vaccinia viruses improves antitumor efficacy mediated by T cell responses.<\/strong> Molecular Therapy-Oncolytics 2021; 22:399-409.<\/p>\n Marruecos L, Manils J, Moreta C, G\u00f3mez D, Filgaira I, Serafin A, Ca\u00f1as X, Espinosa L, Soler C. Single loss of a Trp53 allele triggers an increased oxidative, DNA damage and cytokine inflammatory responses through deregulation of IKBa expression.<\/strong> Cell Death and Disease 2021; 12(4):359.<\/p>\n Dumbovic G, Sanjuan X, Perucho M, Forcales SV. Stimulated emission depletion (STED) super resolution imaging of RNA- and protein-containing domains in fixed cells.<\/strong> Methods 2021; 187:68-76.<\/p>\n\t\t\t\t\tProyectos seleccionados<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\t Small molecule TREX2 inhibitors as novel non-immunosuppressive therapeutics for psoriasis.<\/strong> Ministerio de Ciencia e Innovaci\u00f3n. Ref. PDC2021-120879-I00. 149.500,00 \u20ac. 01\/12\/2021-30\/11\/2023. IP: Concepci\u00f3 Soler Prat. Entitat: Universitat de Barcelona.<\/p>\n New strategies to overcome limitations of immune-oncolytic vaccinia virus threapy<\/strong>. Ministerio de Ciencia, Innovaci\u00f3n y Universidades. Ref. PID2019-109102RA-I00. 145.200,00 \u20ac. 01\/06\/2020-31\/05\/2023. IP: Juan Jos\u00e9 Rojas Exp\u00f3sito. Entitat: Universitat de Barcelona.<\/p>\n Unravelling the mechanisms of macrosatellite NBL2 and its associated lncRNA, TNBL, in cancer; promising new biomarkers and targets for therapy.<\/strong> Ministerio de Ciencia, Innovaci\u00f3n y Universidades. Ref. PID2019-105278RB-I00. 145.200,00 \u20ac. 01\/06\/2020-30\/05\/2023. IP: S\u00f2nia-Vanina Forcales Fern\u00e0ndez. Entitat: Universitat de Barcelona.<\/p>\n Function and mechanisms of TREX2 in skin pathogenesis. A novel strategy for the treatment of psoriasis and atopic dermatitis. Ministerio de Ciencia e Innovaci\u00f3n.<\/strong> Ref. PID2020-114477RB-I00. 108.900,00 \u20ac. 01\/09\/2021-31\/08\/2024. IP: Concepci\u00f3 Soler Prat. Entitat: Universitat de Barcelona.<\/p>\n Targeting TREX2 as innovative keratinocyte-based therapy for psoriasis.<\/strong> \u00abla Caixa\u00bb Foundation. Ref. CI20-00169. 70.000,00 \u20ac. 01\/12\/2020-31\/05\/2022. IP: Concepci\u00f3 Soler Prat. Entitat: Universitat de Barcelona.<\/p>\n Targeting TREX2: a novel apporach for skin-site psoriasis therapy.<\/strong> National Psoriasis Foundation (USA). 62.722,50 \u20ac. 01\/09\/2020-31\/08\/2021. IP: Concepci\u00f3 Soler Prat. Entitat: Universitat de Barcelona.<\/p>\n\t\t\t\t\tTransferencia de tecnolog\u00eda<\/a>\n\t\t\t\t\t\t\t\t\t\t\tExpand<\/i><\/a>\n\t\t\t\t\tPAT084 Inmunidad, inflamaci\u00f3n y c\u00e1ncer Resumen Nuestro grupo se centra en tres l\u00edneas de investigaci\u00f3n. Con respecto a la exonucleasa TREX2, nuestros estudios han sido pioneros en desentra\u00f1ar la expresi\u00f3n espec\u00edfica de TREX2 en los queratinocitos y su papel clave en la carcinog\u00e9nesis cut\u00e1nea y la psoriasis. Tambi\u00e9n estudiamos c\u00f3mo los factores de cromatina integran se\u00f1ales […]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":448,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"publishpress_future_action":{"enabled":false,"date":"2024-05-12 05:20:56","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/17672"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=17672"}],"version-history":[{"count":7,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/17672\/revisions"}],"predecessor-version":[{"id":24220,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/17672\/revisions\/24220"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/448"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=17672"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nIP: Concepci\u00f3 Soler i Francisco Ciruela
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\nTREX2 inhibitors\n\t\t\t\t\n\n\t\tSoler Prat, Concepci\u00f3\n\t<\/h4>\n
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\n\t\tNoticias relacionadas\n\t<\/h2>\n\t\t\n\t\t\t\t<\/a>\n\t\t\tPresentan un virus oncol\u00edtico dirigido a c\u00e9lulas NK con gran potencial antitumoral<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t12\/01\/2024\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tAnna Veiga, nueva Ombudsperson del IDIBELL<\/a>\n\t\t\tBy comunicacio<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t30\/07\/2020\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tIdentifican una mol\u00e9cula clave en el desarrollo de la psoriasis<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t04\/10\/2016\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tS\u00f2nia Forcales: \u00bbBAF60c tiene un papel esencial para la diferenciaci\u00f3n miog\u00e9nica\u00bb<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t13\/12\/2012\t\t\t\t\t\t\t\n\t\t\n\t\t\t\t<\/a>\n\t\t\tEmpieza el curso en el IDIBELL<\/a>\n\t\t\tBy Idibell<\/a>\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t | \n\t\t\t\t\t\t\t\t\t25\/09\/2012\t\t\t\t\t\t\t\n\t\t\n\n","protected":false},"excerpt":{"rendered":"