{"id":17596,"date":"2021-06-30T08:07:33","date_gmt":"2021-06-30T06:07:33","guid":{"rendered":"https:\/\/idibell.cat\/es\/?page_id=17596"},"modified":"2024-11-11T16:42:18","modified_gmt":"2024-11-11T15:42:18","slug":"trastornos-del-neurodesarrollo","status":"publish","type":"page","link":"https:\/\/idibell.cat\/es\/investigacion\/area-de-neurociencias\/programa-de-neurociencias\/trastornos-del-neurodesarrollo\/","title":{"rendered":"Trastornos del neurodesarrollo"},"content":{"rendered":"\n<h1>\n\t\tTrastornos del neurodesarrollo\n\t<\/h1>\n<h3>\n\t\tResumen\n\t<\/h3>\n\t<p>El desarrollo del sistema nervioso central est\u00e1 estrictamente modulado por factores gen\u00e9ticos y ambientales de una manera espacio-temporal. Incluso las alteraciones leves en los genes y \/ o las se\u00f1ales ambientales durante los per\u00edodos cr\u00edticos del desarrollo pre y postnatal, conducen a anomal\u00edas morfol\u00f3gicas y funcionales que comprometer\u00e1n el comportamiento normal y la funci\u00f3n cognitiva. Mediante la identificaci\u00f3n de factores de riesgo y la investigaci\u00f3n de su papel en el desarrollo del sistema nervioso central, utilizando tecnolog\u00edas in vitro e in vivo de vanguardia, tenemos como objetivo dise\u00f1ar estrategias nuevas y m\u00e1s efectivas para la intervenci\u00f3n terap\u00e9utica.<\/p>\n<h2>85<\/h2>\n<h2>Publicaciones<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/es\/wp-content\/uploads\/sites\/4\/2021\/06\/Neurodevelopmental-disorders2.jpg\" alt=\"Neurodevelopmental-disorders2\" itemprop=\"image\" height=\"300\" width=\"600\" title=\"Neurodevelopmental-disorders2\" onerror=\"this.style.display='none'\"  \/>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\">L\u00edneas estrat\u00e9gicas<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-0\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-0\"><i>Expand<\/i><\/a>\n\t\t\t\t\t&#8211; Neurogen\u00f3mica funcional<br \/>\n&#8211; Estrategias biomim\u00e9ticas para dirigir el desarrollo y regeneraci\u00f3n neural<br \/>\n&#8211; Modelado humano de trastornos neurol\u00f3gicos\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\">Publicaciones seleccionadas<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-1\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-1\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>Alvarez,Z;Ortega,JA;Sato,K;Sasselli,IR;Kolberg Edelbrock,AN;Qiu,RM;Marshall,KA et al, <strong>Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons<\/strong>, Cell Stem Cell, 2023;30(2):219-doi:10.1016\/j.stem.2022.12.010<\/li>\n<li>SMITH, C. S., \u00c1LVAREZ, Z., QIU, R., SASSELLI, I. R., CLEMONS, T., ORTEGA, J. A., VILELA-PICOS, M., WELLMAN, H., KISKINIS, E. &amp; STUPP, S. I. 2023. <strong>Enhanced Neuron Growth and Electrical Activity by a Supramolecular Netrin-1 Mimetic Nanofiber<\/strong>. ACS Nano, 17, 19887-19902<\/li>\n<li>Ortega JA, Sasselli IR, Boccitto M, Fleming AC, Fortuna TR, Li Y, Sato K, Clemons TD, Mckenna ED, Nguyen TP, Anderson EN, Asin J, Ichida JK, Pandey UB, Wolin SL, Stupp SI, Kiskinis E. <strong>CLIP-Seq analysis enables the design of protective ribosomal RNA bait oligonucleotides against C9ORF72 ALS\/FTD poly-GR pathophysiology<\/strong>. Sci Adv. 2023 Nov 10;9(45):eadf7997. doi: 10.1126\/sciadv.adf7997<\/li>\n<li>Musokhranova,U;Grau,C;Vergara,C;Rodr\u00edguez Pascau,L;Xiol,C;Castells,AA;Alc\u00e1ntara,S et al, <strong>Mitochondrial modulation with leriglitazone as a potential treatment for Rett syndrome<\/strong>., J. Transl. Med., 2023;21(1):756-756, doi:10.1186\/s12967-023-04622-5<\/li>\n<li>Garcia Gonzalez,L;Marti Sarrias,A;Puertas,MC;Bayon Gil,A;Resa Infante,P;Martinez Picado,J;Navarro,A et al, <strong>Understanding the neurological implications of acute and long COVID using brain organoids, Dis. Model<\/strong>. Mech., 2023;16(7):doi:10.1242\/dmm.050049<\/li>\n<\/ul>\n\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--label-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\">Proyectos seleccionados<\/a>\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-accordion--icon-2\" tabindex=\"0\" aria-controls=\"fl-accordion--panel-2\"><i>Expand<\/i><\/a>\n\t\t\t\t\t<ul>\n<li>PUB22026. <strong>INVESTIGO 2022<\/strong>. SERVICIO PUBLICO DE EMPLEO ESTATAL SEPE. Budget: 66.217,68\u20ac. 2022 &#8211; . PI: Ortega Cano, Juan Alberto.<\/li>\n<li>INT23001. <strong>theALSmatrisome: Defining the contribution of ALS-associated alterations in motor neuron microenvironment to disease pathogenesis<\/strong>. ASSOCIATION FRAN\u00c7AISE CONTRE LES MYOPATHIES (FRENCH MUSCULAR DYSTROPHY ASSOCIATION) AFM-T\u00c9L\u00c9THON.\u00a0Budget: 30.000,00\u20ac. 2023-2025. PI: Ortega Cano, Juan Alberto.<\/li>\n<\/ul>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/es\/wp-content\/uploads\/sites\/4\/2022\/11\/Soledad-Alcantara22-150x150.jpg\" alt=\"Soledad-Alcantara22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Soledad-Alcantara22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tAlc\u00e1ntara Horrillo, Soledad\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:salcantara@idibell.cat\" title=\"salcantara@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tsalcantara@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tInvestigadores principales\n\t<\/h2>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/es\/wp-content\/uploads\/sites\/4\/2022\/11\/Soledad-Alcantara22-150x150.jpg\" alt=\"Soledad-Alcantara22\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Soledad-Alcantara22\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tAlc\u00e1ntara Horrillo, Soledad\n\t<\/h4>\n<h4>\n\t\t<a href=\"mailto:salcantara@idibell.cat\" title=\"salcantara@idibell.cat\" target=\"_blank\" rel=\"noopener\">\n\t\tsalcantara@idibell.cat\n\t\t<\/a>\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/es\/wp-content\/uploads\/sites\/4\/2021\/06\/Sandra-Acosta-Verdugo-150x150.jpg\" alt=\"Sandra-Acosta-Verdugo\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"Sandra-Acosta-Verdugo\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tAcosta Verdugo, Sandra\n\t<\/h4>\n\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/idibell.cat\/es\/wp-content\/uploads\/sites\/4\/2021\/06\/J-Alberto-Ortega-Cano-150x150.jpg\" alt=\"J-Alberto-Ortega-Cano\" itemprop=\"image\" height=\"150\" width=\"150\" title=\"J-Alberto-Ortega-Cano\" onerror=\"this.style.display='none'\"  \/>\n<h4>\n\t\tOrtega Cano, Alberto\n\t<\/h4>\n<h4>\n\t\tENLACES RELACIONADOS\n\t<\/h4>\n<h4>\n\t\t<a href=\"http:\/\/www.neurociencies.ub.edu\/neurodevelopmental-disorders\/\" title=\"Instituto de Neurociencias UB\" target=\"_blank\" rel=\"noopener\">\n\t\tInstituto de Neurociencias UB\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/www.ub.edu\/portal\/web\/dp-patologia-terapeutica\/laboratori-de-desenvolupament-neural-ndlab-\" title=\"Soledad Alc\u00e1ntara - NDLab\" target=\"_blank\" rel=\"noopener\">\n\t\tSoledad Alc\u00e1ntara &#8211; NDLab\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"http:\/\/www.acostalab.cat\/\" title=\"Acosta Lab\" target=\"_blank\" rel=\"noopener\">\n\t\tAcosta Lab\n\t\t<\/a>\n\t<\/h4>\n<h4>\n\t\t<a href=\"https:\/\/twitter.com\/sacostav\" title=\"@sacostav\" target=\"_blank\" rel=\"noopener\">\n\t\t@sacostav\n\t\t<\/a>\n\t<\/h4>\n<h2>\n\t\tEquipo\n\t<\/h2>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-0\" data-index=\"0\" aria-selected=\"true\" aria-controls=\"fl-tabs--panel-0\" aria-expanded=\"true\" role=\"tab\" tabindex=\"0\">\t\t\t\tJefes\/as de grupo\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-1\" data-index=\"1\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-1\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadores\/as principales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-2\" data-index=\"2\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-2\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadores\/as postdoctorales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-3\" data-index=\"3\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-3\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tInvestigadores\/as predoctorales\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<a href=\"#\" id=\"fl-tabs--label-4\" data-index=\"4\" aria-selected=\"false\" aria-controls=\"fl-tabs--panel-4\" aria-expanded=\"false\" role=\"tab\" tabindex=\"0\">\t\t\t\tSoporte cient\u00edfico\t\t\t\t<\/a>\n\t\t\t\t\t\tJefes\/as de grupo\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Alc\u00e1ntara Horrillo, Soledad<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadores\/as principales\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Acosta Verdugo, Sandra<\/li>\n<li>Ortega Cano, Alberto<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadores\/as postdoctorales\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Garc\u00eda Gonz\u00e1lez, Laura<\/li>\n<\/ul>\n\t\t\t\t\t\tInvestigadores\/as predoctorales\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Soriano Esque, Jos\u00e9 Pablo<\/li>\n<li>Soares de Aguiar, Gisele Priscila<\/li>\n<li>Mart\u00ed Sarrias, Andrea<\/li>\n<li>Turpin Moreno, Isabel<\/li>\n<\/ul>\n\t\t\t\t\t\tSoporte cient\u00edfico\n\t\t\t\t\t\t\t\t\t\t\t<ul>\n<li>Cuenca Medina, Marta<\/li>\n<\/ul>\n<h2>\n\t\tNoticias relacionadas\n\t<\/h2>\n\t<meta itemscope itemprop=\"mainEntityOfPage\" itemtype=\"https:\/\/schema.org\/WebPage\" itemid=\"http:\/\/25046\" content=\"BioCl\u00faster, gamificaci\u00f3n e innovaci\u00f3n en salud: la participaci\u00f3n del IDIBELL en el Smart City Expo World Congress 2024\" \/><meta itemprop=\"datePublished\" 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Incluso las alteraciones leves en los genes y \/ o las se\u00f1ales ambientales durante los per\u00edodos cr\u00edticos del desarrollo pre y postnatal, conducen a anomal\u00edas morfol\u00f3gicas y funcionales que comprometer\u00e1n el comportamiento normal [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":503,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-17596","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2024-12-01 12:30:58","action":"change-status","newStatus":"draft","terms":[],"taxonomy":""},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/17596","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/comments?post=17596"}],"version-history":[{"count":9,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/17596\/revisions"}],"predecessor-version":[{"id":25064,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/17596\/revisions\/25064"}],"up":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/pages\/503"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=17596"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}