{"id":26298,"date":"2025-06-25T10:58:35","date_gmt":"2025-06-25T08:58:35","guid":{"rendered":"https:\/\/idibell.cat\/es\/?post_type=agenda&p=26298"},"modified":"2025-06-25T11:28:01","modified_gmt":"2025-06-25T09:28:01","slug":"facultyseminars-opioid-induced-neurotoxicity-after-opioid-rotation-to-methadone-with-stop-and-go-method-in-patients-with-cancer-pain-a-multicenter-retrospective-cohort-study","status":"publish","type":"agenda","link":"https:\/\/idibell.cat\/es\/agenda\/facultyseminars-opioid-induced-neurotoxicity-after-opioid-rotation-to-methadone-with-stop-and-go-method-in-patients-with-cancer-pain-a-multicenter-retrospective-cohort-study\/","title":{"rendered":"#Facultyseminars: Opioid-Induced Neurotoxicity after Opioid Rotation to Methadone with Stop-and-Go Method in patients with Cancer Pain: a multicenter retrospective cohort study."},"content":{"rendered":"

Premise:<\/strong><\/p>\n

Opioid rotation(OR) to methadone is a common strategy for managing cancer pain. However, the safety of the Stop-and-Go(SAG) method regarding neurotoxicity induced by opioids(NIO) remains uncertain.<\/p>\n

Scope:
\n<\/strong>To identify variables associated with NIO within 14 days after opioid rotation to methadone using SAG method in patients with inadequate pain control.<\/p>\n

Material and methods:
\n<\/strong>Multicenter retrospective cohort study in two oncology centers(January 2018-October 2022). Hospitalized cancer patients \u226518 years undergoing OR to methadone with the SAG method for pain management were included. Ethics committee approval was obtained.<\/p>\n

Results:
\n<\/strong>372 patients were included. The mean daily morphine equivalent dose prior OR was 212.2 mg(SD 128). 58% were using fentanyl before ROP. Pain improved in 62.2% of patients after OR.
\n70 patients(18.8%) developed NIO after OR. Younger patients had lower rates of NIO(mean age 59.4 versus 63years; p=0.032). Women showed a trend towards lower NIO rates compared to men (13% versus 22%;p=0.065).
\nPatients with cognitive failure or delirium before OR presented more NIO compared to those without cognitive impairment (52.4% versus 16.8%;p<0.001).
\nSimilar distributions of the rates of patients presenting NIO after OR were observed regarding previous tobacco use(p=0.229), alcohol consumption(p=0.270), disease stage(p=0.823), chemotherapy use in the last month(p=0.11), pain pathophysiology(p=0.567),\u00a0previous doses of opioids(p=0.786), and previous opioid(p=0.876).<\/p>\n

Conclusions:
\n<\/strong>Opioid rotation to methadone using the SAG method was associated with a low rate of NIO (<20%). These findings suggest that OR to methadone with SAG method could be considered a safe procedure, especially in younger patients and in those without cognitive impairment.<\/p>\n","protected":false},"featured_media":26299,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"tags":[402],"class_list":["post-26298","agenda","type-agenda","status-publish","has-post-thumbnail","hentry","tag-cancer"],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/agenda\/26298","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/agenda"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/agenda"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/26299"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=26298"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=26298"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}