Uterine leiomyomas (ULs) are benign yet neoplastic tumors of the uterine smooth muscle wall. They are remarkably frequent, as up to 70% of all women develop these lesions during lifetime. About 20% of women develop symptoms, such as abnormal menstrual bleeding, pelvic pain and infertility. While ULs display little malignant potential, research on these tumors has been extremely fruitful not only in allowing molecular stratification of ULs into different subclasses with mutually exclusive driver genes and characteristic clinicopathological features, but also by contributing to our understanding on mechanisms of neoplasia in general. This talk will review some lessons learnt through Helsinki myoma study, a research program that has been running for 25 years.<\/p>\n
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