Molecular biomarkers can be used to detect cancer in minimally- and non-invasive sample types. An emerging biomarker for early cancer detection is DNA methylation, a common epigenetic event associated with tumor suppressor gene silencing.
\nTo study the diagnostic potential of methylation markers for gynecological cancer detection, we have collected paired urine samples, self-collected cervicovaginal swabs, and cervical scrapes from women diagnosed with cervical (pre)cancer, endometrial cancer and ovarian cancer. Urine and cervicovaginal swabs were collected at home.
\nBoth for cervical (pre)cancer and endometrial cancer it was found that methylation levels were significantly increased in patients compared to controls in all sample types (>90% sensitivity\/specificity). Results for ovarian cancer were less evident.
\nThis demonstrates the potential of methylation testing in at-home collected material as a novel diagnostic strategy for the (early) detection of cervical and endometrial cancer.<\/p>\n
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