{"id":17581,"date":"2021-06-29T10:26:32","date_gmt":"2021-06-29T08:26:32","guid":{"rendered":"https:\/\/idibell.cat\/es\/?post_type=agenda&#038;p=17581"},"modified":"2021-06-29T10:40:47","modified_gmt":"2021-06-29T08:40:47","slug":"idibellseminars-deciphering-the-clinical-and-biological-implications-of-brca2-mutant-prostate-cancer","status":"publish","type":"agenda","link":"https:\/\/idibell.cat\/es\/agenda\/idibellseminars-deciphering-the-clinical-and-biological-implications-of-brca2-mutant-prostate-cancer\/","title":{"rendered":"#IDIBELLseminars: Deciphering the clinical and biological implications of BRCA2 mutant prostate cancer"},"content":{"rendered":"<p>My research aim is to improve the outcomes of prostate cancer patients by understanding the biology behind the most aggressive forms of prostate cancer. My group has focused on understanding how genetic defects in DNA repair and DNA damage response pathways combine with other alterations to drive or suppress oncogenesis and tumor progression and in the identification of critical molecular characteristics that cause some cancers to metastasize and\/or fail to respond to available antitumor therapies. We use a reverse translational approach from the bedside to the bench and back again through a multidisciplinary approach that requires of different tools such as bioinformatics, genomics, cell lines, patient derived organoids and xenografts, genetically engineered mouse models, as well as patients\u2019 samples with available well-annotated and curated data from clinical trials. Our ultimate goal is to uncover how we can exploit these tumor characteristics to better stratify and treat patients.<\/p>\n<p><em>Hosted by Alvaro Aytes.<\/em><br \/>\n<em> Resistance and Progression Mechanisms in Prostate Cancer Group, IDIBELL<\/em><\/p>\n","protected":false},"featured_media":17582,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}}},"tags":[],"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/agenda\/17581"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/agenda"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/agenda"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/17582"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=17581"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=17581"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}