{"id":16917,"date":"2021-05-10T09:00:42","date_gmt":"2021-05-10T07:00:42","guid":{"rendered":"https:\/\/idibell.cat\/es\/?post_type=agenda&#038;p=16917"},"modified":"2021-05-10T09:00:42","modified_gmt":"2021-05-10T07:00:42","slug":"idibellseminars-animal-models-for-human-liver-cancer-from-pathogenesis-to-therapy","status":"publish","type":"agenda","link":"https:\/\/idibell.cat\/es\/agenda\/idibellseminars-animal-models-for-human-liver-cancer-from-pathogenesis-to-therapy\/","title":{"rendered":"#IDIBELLseminars: Animal models for human liver cancer: From pathogenesis to therapy"},"content":{"rendered":"<p><strong>Diego F. Calvisi<\/strong><br \/>\nInstitute of Pathology, University of Regensburg, Germany<\/p>\n<p>Primary liver cancer (PLC) ranks among the most frequent and deadly tumor entities worldwide. PLC consists mainly of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) in adults and hepatoblastoma (HB) in children. Due to the late diagnosis, the vast majority of cases of HCC and CCA cannot be curatively treated, and systemic treatments remain of limited efficacy. Thus, more efficacious therapies are urgently needed. For this purpose, a better understanding of the molecular events underlying PLC is imperative.<br \/>\nUsing a comprehensive approach consisting of PLC-derived cell lines, ad hoc generated mouse models using hydrodynamic gene technology, and human tumor specimens, we have investigated various signaling pathways responsible for PLC onset and progression, both in terms of the molecular pathogenesis of the tumors and experimental therapeutics. The results obtained by our investigations indicate that PLC is a highly heterogeneous disease characterized by distinct molecular features in various tumor subsets. Thus, appropriate models recapitulating the uniqueness of each tumor subset should be generated and investigated for the development of more effective therapies against this aggressive disease.<\/p>\n<p><em>Hosted by Isabel Fabregat<\/em><\/p>\n","protected":false},"featured_media":16918,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"tags":[],"class_list":["post-16917","agenda","type-agenda","status-publish","has-post-thumbnail","hentry"],"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/agenda\/16917","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/agenda"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/agenda"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/16918"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=16917"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=16917"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}