{"id":16751,"date":"2021-04-25T22:46:41","date_gmt":"2021-04-25T20:46:41","guid":{"rendered":"https:\/\/idibell.cat\/es\/?post_type=agenda&#038;p=16751"},"modified":"2021-04-25T22:46:41","modified_gmt":"2021-04-25T20:46:41","slug":"idibellseminars-inhibition-of-the-sulfatase-of-steroid-hormones-improves-aging-and-symptoms-of-alzheimers-disease-in-nematode-and-mice-models","status":"publish","type":"agenda","link":"https:\/\/idibell.cat\/es\/agenda\/idibellseminars-inhibition-of-the-sulfatase-of-steroid-hormones-improves-aging-and-symptoms-of-alzheimers-disease-in-nematode-and-mice-models\/","title":{"rendered":"#IDIBELLseminars: Inhibition of the sulfatase of steroid hormones improves aging and symptoms of Alzheimer\u2019s disease in nematode and mice models"},"content":{"rendered":"<p><strong>Manuel Mu\u00f1oz<\/strong><br \/>\nCentro Andaluz de Biolog\u00eda del Desarrollo &#8211; Pablo Olavide University<br \/>\nSteroid hormones can be modified by adding a sulfate moiety, which generates a profound change in their chemical properties. This modification is traditionally considered to inactivate the hormones and can be reversed by the activity of the sulfatase of steroid hormone gene (SUL-2 in nematode, STS in humans). Using the nematode C. elegans, we have observed that the reduction of the activity of sul-2 gene generates an increase of longevity. Aging and reduction of protein homeostasis are linked process. We have found that inhibition of this activity either by mutation or by pharmacological treatment, improves symptoms of models of neurodegeneration in C. elegans (Alzheimer, Parkinson and Huntington\u2019s Corea). We have also tested the inhibition of the sulfatase of steroid hormones in mouse model of Alzheimer\u2019s disease and we observed that this treatment generates an improvement of the cognitive deficiency caused by the disease and reduction of plaque formation of \u03b2-amyloid. We propose that pharmacological inhibition of the sulfatase of steroid hormones could be of potential interest for treatment of Alzheimer\u2019s disease in humans.<\/p>\n<p><em>Hosted by Juli\u00e1n Cer\u00f3n<\/em><\/p>\n","protected":false},"featured_media":16752,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}}},"tags":[392],"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/agenda\/16751"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/agenda"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/agenda"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/16752"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=16751"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=16751"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}