{"id":15573,"date":"2020-11-24T08:15:06","date_gmt":"2020-11-24T07:15:06","guid":{"rendered":"https:\/\/idibell.cat\/es\/?post_type=agenda&#038;p=15573"},"modified":"2020-11-24T08:15:06","modified_gmt":"2020-11-24T07:15:06","slug":"idibellconnect-the-mtor-larp1-axis-and-the-anabolic-reservoir-of-tumor-cells-a-new-therapeutic-target-in-colorectal-cancer-and-beyond","status":"publish","type":"agenda","link":"https:\/\/idibell.cat\/es\/agenda\/idibellconnect-the-mtor-larp1-axis-and-the-anabolic-reservoir-of-tumor-cells-a-new-therapeutic-target-in-colorectal-cancer-and-beyond\/","title":{"rendered":"#IDIBELLconnect: The mTOR-LARP1 axis and the anabolic reservoir of tumor cells: A new therapeutic target in colorectal cancer and beyond"},"content":{"rendered":"<p>Protein synthesis is the final step of the central dogma of biology that converts the genetic information into functional proteins. Ribosomes are in charge of this last step, operating as the cellular factories that generate basically all the cellular biomass. To grow and proliferate cancer cells have a high demand in protein synthesis rate, which in turn requires the hyper activation of the process of ribosome biogenesis.<br \/>\nA central question in cancer biology is how cancer cells hijack the protein synthetic pathway and alter the cellular translational program to meet the high anabolic demand. We have recently discovered that the translatome has an innate hierarchy that places all the ribosome biosynthesis components on the top of the cellular translational program. Thanks to the 40S-LARP1 complex the protein synthesis capacity is preserved in the form of mRNAs upon adverse growth condition characterized by mTOR inhibition. This constitutes an anabolic reservoir that tumor cells can spend when growing conditions return permissive, potentially conferring a metabolic resistance in the process of tumorigenesis and upon chemotherapeutic treatments.<\/p>\n","protected":false},"featured_media":15574,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"default","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}}},"tags":[],"_links":{"self":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/agenda\/15573"}],"collection":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/agenda"}],"about":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/types\/agenda"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media\/15574"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/media?parent=15573"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/es\/wp-json\/wp\/v2\/tags?post=15573"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}