Regeneración del páncreas: progenitores pancreáticos y sus nichos

Desarrollar terapias para mantener la normoglicemia en pacientes diabéticos para evitar o reducir las complicaciones de la diabetes tipo 1.

Desarrollar terapias regenerativas en diabetes humana, ya sea mediante la manipulación de tejido exocrino pancreático de donantes in vitro y su posterior trasplante, o mediante la manipulación in vivo o in vitro de las células del conducto pancreático de los pacientes.

Pancreatic β-cell regeneration: advances in understanding the genes and signaling pathways involved

Solomon Afelik* and Meritxell Rovira*. Genome Medicine. 05/2017. Review. *Corresponding authors.

 

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Pancreas β-cell regeneration: facultative or dedicated progenitors? Molecular and Cellular Endocrinology

Solomon Afelik* and Meritxell Rovira*. 445:85-94. 04/2017. Review. *Corresponding authors.

 

Centraocinar cells: At the center of pancreas regeneration

Rebecca L. Beer RL*, Michael J. Parsons, Meritxell Rovira*. Developmental Biology. Volume 413, Issue 1, 1 May 2016, Pages 8–15. Review. * Corresponding authors.

 

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Centroacinar cells are progenitors that contribute to endocrine pancreas regeneration

Fabien Delaspre*; Rebecca L. Beer*; Meritxell Rovira; Wei Huang; Guangliang Wang; Stephen Gee; Maria Del Carmen Vitery; Sarah J. Wheelan; Michael J. Parsons. Diabetes. pp 3499-509. 07/2015. ISSN 1939-327. *authors contributed equally to this work.

 

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TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors

Inês Cebola*; Santiago A. Rodríguez-Seguí*; Candy H.-H*. Cho; José Bessa*; Meritxell Rovira*, Mario Luengo; Mariya Chhatriwala; Andrew Berry; Joan Ponsa-Cobas; Miguel Angel Maestro; Rachel E. Jennings; Lorenzo Pasquali; Ignasi Morán; Natalia Castro; Neil A. Hanley; Jose Luis Gomez Skarmeta; Ludovic Vallier; Jorge Ferrer. Nature Cell Biology. 17 – 5, pp. 615 – 626. 05/2015. ISSN 1476-4679. *authors contributed equally to this work.

 

Weaning gives β cells license to regenerate

Meritxell Rovira*; Jorge Ferrer*. Developmental Cell. 32 – 5, pp. 531 -532. 03/2015. ISSN 1878-1551. *corresponding authors. Editorial.

 

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Chemical screen identifies {FDA-approved} drugs and target pathways that induce precocious pancreatic endocrine differentiation

Meritxell Rovira; Wei Huang; Shamila Yusuff; Joong Sup Shim; Anthony A Ferrante; Jun O Liu; Michael J Parsons. Proceedings of the National Academy of Sciences of the United States of America. 108 -48, pp. 19264 – 19269. 11/2011. ISSN 1091-6490

 

Genetic inducible fate mapping in larval zebrafish reveals origins of adult insulin-producing β-cells

Yiyun Wang; Meritxell Rovira; Shamila Yusuff; Michael J Parsons. Development (Cambridge, England). 138 – 4, pp. 609 -617. 02/2011. ISSN 1477-9129

 

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Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas

Meritxell Rovira; Sherri-Gae Scott; Andrew S Liss; Jan Jensen; Sarah P Thayer; Steven D Leach. Proceedings of the National Academy of Sciences of the United States of America. 107 – 1, pp. 75 – 80. 01/2010. ISSN 1091-6490

 

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Murine embryonic stem cell-derived pancreatic acinar cells recapitulate features of early pancreatic differentiation

Meritxell Rovira; Fabien Delaspre; Mohammad Massumi; Selma A Serra; Miguel Angel Valverde; Josep Lloreta; Marlène Dufresne; Bruno Payré; Stephen F Konieczny; Pierre Savatier; Francisco X Real; Anouchka Skoudy. Gastroenterology. 135 – 4, pp. 1301 – 5. 10/2008. ISSN 1528-0012

 

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Viral-mediated coexpression of Pdx1 and p48 regulates exocrine pancreatic differentiation in mouse ES cells

Meritxell Rovira; Judit Jané-Valbuena; Mélanie Marchand; Pierre Savatier; Francisco X Real; Anouchka Skoudy. Cloning and Stem Cells. 9 – 3, pp. 327 – 338. 2007. ISSN 1536-2302