#IDIBELLfellows: Iswarya Sreeram / Ana Cantos Cortes

From Senescence to cell death: exploring novel therapeutic approaches in Malignant Pleural Mesothelioma (MPM)
Iswarya Sreeram – Preclinical and experimental research in thoracic tumors (PreTT) Group

Malignant Pleural Mesothelioma (MPM) is an aggressive neoplasm caused by exposure to asbestos fibres. The standard treatment consists of chemotherapy but few patients achieve long-term survival and novel therapeutic approaches are needed. This talk would be about the effect of CDK4/6 inhibitor, palbociclib: It causes cell cycle arrest and senescent-like phenotype in MPM cells but it does not kill them. We explored the combination of senolytics and palbociclib to observe possible effects in cell death. We will present these data and other combination approaches that may contribute to eradicate MPM cells.

New experimental approaches to analyze the role of TGF-β in liver tumor microenvironment
Ana Cantos Cortes – TGF-beta & Cancer Group