{"id":6802,"date":"2011-11-29T00:00:00","date_gmt":"2011-11-28T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/en\/blog\/2020\/05\/01\/the-dark-genome-and-human-disease\/"},"modified":"2023-03-03T16:06:35","modified_gmt":"2023-03-03T15:06:35","slug":"the-dark-genome-and-human-disease","status":"publish","type":"post","link":"https:\/\/idibell.cat\/en\/2011\/11\/the-dark-genome-and-human-disease\/","title":{"rendered":"The dark genome and human disease"},"content":{"rendered":"<p>The best well-studied genome sequences are genes that encode proteins, but only represent 1.5% of the genome. Therefore, much of the genome, called dark genome, comprises transcribed sequences that may have a critical biological importance.<\/p>\n<p>The importance of this functional part of the genome that encodes proteins is particularly evident in a group of non-coding RNAs, microRNAs. In human cancer, studies by our group and others have shown that epigenetic and genetic defects in microRNA processing and in their machinery are a common feature of the disease. But beyond the microRNAs there are other non-coding RNAs that may be altered in cancer cells?<\/p>\n<p>The director of the Cancer Epigenetics and Biology Program (PEBC) at IDIBELL, Manel Esteller, has published an article at the journal <a href=\"http:\/\/www.nature.com\/nrg\/journal\/v12\/n12\/index.html\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"enllac\">Nature Reviews Genetics <\/span><\/a>in addressing this issue, highlighting the emerging role of new technologies of genomics and epigenomics to study classes of non-coding RNAs, microRNAs different: Transcribed-ultraconserved Regions (T-RCUs), small nucleolar RNPs (snoRNPs), PIWI-associated RNAs (piRNAs) and the heterogeneous group of non-coding RNAs long (lncRNAs).<\/p>\n<p>The research results will enable us to obtain in the future the first non-coding transcript genome map in human cancer, an &#8220;epigenetic signature&#8221; that could have consequences not only valuable for the understanding of disease but also for the development of new markers molecular and targeted therapies.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Article&#8217;s reference<\/strong><\/p>\n<p>Esteller M. Non-coding RNAS in human disease. Nature Review Genetics 12, 861-874 (December 2011) | doi: 10.1038\/nrg3074<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Article&#8217;s reference<\/p>\n","protected":false},"author":6,"featured_media":22172,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[],"tags":[],"class_list":["post-6802","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"publishpress_future_action":{"enabled":false,"date":"2025-01-29 05:04:48","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts\/6802","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=6802"}],"version-history":[{"count":3,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts\/6802\/revisions"}],"predecessor-version":[{"id":22174,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts\/6802\/revisions\/22174"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media\/22172"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=6802"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/categories?post=6802"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/tags?post=6802"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}