The study of the molecular mechanisms that regulate the signaling pathways of transforming growth factor (TGF-beta) is the field of action of Peter Ten Djike and his research group at the University of Leiden, the Netherlands. Ten Djike explained their latest developments in a lecture in the seminar series IDIBELL on March 2.<\/p>\n
TGF-beta is involved in the regulation of many cellular processes. With respect to tumors has been shown to have a dual function contradictory. On one hand, in the initial state induces programmed cell death, so that it has a suppressive function of tumor growth, but in more advanced phases promotes cell migration and invasion, and therefore the metastasis.<\/p>\n
“We are interested in this second role of TGF-beta” explained Ten Djike “because most patients do not die from a primary tumor but for its expansion and metastasis to other body parts.” His group studies receptors involved in the signaling pathway of TGF-beta that induces proliferation “they are enzymes and molecules that can be targeted by therapeutic treatments to inhibit the final action of TGF-beta to promote metastasis.”<\/p>\n
Ten Dijke works with different molecules that are potential targets. He talked about TRAF4 in breast cancer “is a negative regulator of the signaling pathway of TGF-beta. If we inhibit this enzyme, we are inhibiting migration, invasion, therefore metastasis, induced by TGF-beta in breast cancer cells”.<\/p>\n
Another approach that is already in clinical trials involving a pharmaceutical company is the inhibition of angiogenesis (genesis of blood vessels needed for nutrition and growth of tumor cells) induced by TGF-beta. “Inhibiting ALK receptor 1 and getting an antiangiogenic effect that makes tumor cells can not grow or migrate.”<\/p>\n","protected":false},"excerpt":{"rendered":"
The study of the molecular mechanisms that regulate the signaling pathways of transforming growth factor (TGF-beta) is the field of action of Peter Ten Djike and his research group at the University of Leiden, the Netherlands. Ten Djike explained their latest developments in a lecture in the seminar series IDIBELL on March 2. TGF-beta is […]<\/p>\n","protected":false},"author":6,"featured_media":22074,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-6738","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sin-categorizar"],"publishpress_future_action":{"enabled":false,"date":"2024-11-29 13:40:50","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts\/6738","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=6738"}],"version-history":[{"count":2,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts\/6738\/revisions"}],"predecessor-version":[{"id":22073,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts\/6738\/revisions\/22073"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media\/22074"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=6738"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/categories?post=6738"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/tags?post=6738"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}