A study by the Bellvitge Institute of Biomedical Research (IDIBELL ) led by the head of the research group in signaling pathways in angiogenesis , Mariona Graupera concludes that p110alpha protein inhibition in mice causes a reduction of tumor growth associated with a defect in blood vessel formation . Study results were published in the Journal of Experimental Medicine. The p110alpha is an isoform ( variant ) of the PI3Kinas, a protein which is altered in one way or another by more than 30 % of tumors . In a previous study , Graupera group had already shown that this isoform has a key role in the physiological process of blood vessel formation , called angiogenesis. ” What we wanted to check in this work,” says researcher ” is whether in context of cancer it also plays that role.”<\/p>\n
Angiogenesis<\/strong><\/p>\n Angiogenesis is a key process in the growth, proliferation and migration of solid tumors. Tumor cells need new blood vessels that provide extra oxygen and nutrients they need to grow a fast pace .<\/p>\n Researchers inhibited P110alpha by two strategies: with drugs and genetically engineered mice that do not express the protein. ” In both cases” Mariona Graupera explained ” its inhibition causes a slowing of tumor growth, associated with a defect in the formation of blood vessels.”<\/p>\n ” There are more vessels but they are smaller than normal and do not work well . So there dos not reach to tumor cells all the oxygen and nutrients they need.”<\/p>\n Alternative to conventional therapies<\/strong><\/p>\n According to Graupera “this study opens the door, although in a very initial stage,to new antiangiogenic therapies, that will be alternative to conventional therapies which inhibit VEGF and may eventually develop resistance and malignancy.”<\/p>\n <\/p>\n Article’s reference Soler A., Serra H., Pearce W., Angulo A., Guillermet-Guibert J., Friedman L.S., Vi\u00f1als F., Gerhardt H., Casanovas O., Graupera M. and Bart Vanhaesebroeck. Inhibition of the 110alpha isofrom of PI 3-Kinase stimulates nonfunctional tumor angiogenesis.<\/strong> The Journal of Experimental Medicien. 2013. september<\/p>\n","protected":false},"excerpt":{"rendered":" A study by the Bellvitge Institute of Biomedical Research (IDIBELL ) led by the head of the research group in signaling pathways in angiogenesis , Mariona Graupera concludes that p110alpha protein inhibition in mice causes a reduction of tumor growth associated with a defect in blood vessel formation . Study results were published in the […]<\/p>\n","protected":false},"author":6,"featured_media":19002,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[180,264,296,208,294],"tags":[],"class_list":["post-6274","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cancer","category-molecular-mechanisms-and-experimental-therapy-in-oncology-program-oncobell","category-molecular-signalling-in-cancer","category-tumour-angiogenesis","category-vascular-biology-and-signalling"],"publishpress_future_action":{"enabled":false,"date":"2025-04-09 21:45:01","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts\/6274","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=6274"}],"version-history":[{"count":3,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts\/6274\/revisions"}],"predecessor-version":[{"id":19003,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts\/6274\/revisions\/19003"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media\/19002"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=6274"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/categories?post=6274"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/tags?post=6274"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
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