{"id":5487,"date":"2016-12-13T00:00:00","date_gmt":"2016-12-12T23:00:00","guid":{"rendered":"https:\/\/idibell.cat\/en\/blog\/2020\/05\/01\/caixaimpulse-funds-an-idibell-project-on-hospital-acquired-infections\/"},"modified":"2020-08-07T10:56:50","modified_gmt":"2020-08-07T08:56:50","slug":"caixaimpulse-funds-an-idibell-project-on-hospital-acquired-infections","status":"publish","type":"post","link":"https:\/\/idibell.cat\/en\/2016\/12\/caixaimpulse-funds-an-idibell-project-on-hospital-acquired-infections\/","title":{"rendered":"CaixaImpulse funds an IDIBELL project on hospital-acquired infections"},"content":{"rendered":"

Removal of antibodies with glycoconjugates<\/strong>
\n<\/strong> It is estimated that hospital-acquired or nocosomial infections are one of the leading causes of mortality both in Europe and the United States, affecting 10% of admitted patients. Gram-negative bacteria account for the vast majority of infections, and are associated with severe clinical conditions such as sepsis and septic shock.<\/p>\n

Antibody-dependent enhancement (ADE) of infection occurs when pre-exisiting non-neutralizing antibodies bind to a pathogen, facilitating infection instead of dampening it. The unique and novel approach developed by Dr. M\u00e1nez\u2019s research group aims to boost immunity in these patients by deactivating non-neutralizing antibodies with glycoconjugates, thus priming neutralizing antibodies.<\/p>\n

This selective depletion of ADE antibodies by glycoconjugates will improve serum bactericidal activity and prevents mortality in experimental Gram-negative infections.<\/p>\n

The use of glycoconjugates to boost immunity is a unique novel approach both for its mechanism of action and effect, which could become a very effective therapy to fight infections by Gram-negative. The possibility of boosting immunity by only depleting the non-neutralizing antibodies in the body represents a radical innovation as a therapeutic approach, which could also be used in other infections and cancer. According to the Innovation Union Scoreboard 2016 (IUS) report, Spain has cutting-edge infrastructure, first-rate research centres, and professionals.<\/p>\n

Nevertheless, it is ranked 21st in the European Union (EU) for innovation.<\/p>\n

In order to help change this reality, Obra Social \u201dla<\/p>\n

Caixa\u201d and Caixa Capital Risc launched CaixaImpulse, which uses their expertise in the fields of research, creation, development and investment in early-stage companies for a common aim: the transfer of research results to society.<\/p>\n

Jordi Portabella, Director of Research and Knowledge at the \u201dla Caixa\u201d Banking Foundation, and Carlos Trenchs, Managing Director at Caixa Capital Risc, presented all the selected innovative proposals yesterday.<\/p>\n

Of the 73 projects that were initially submitted, a committee of experts have chosen the 20 finalists, 3 of which belong to the field of life sciences, while 17 belong to the medical sciences and healthcare sectors.<\/p>\n","protected":false},"excerpt":{"rendered":"

Removal of antibodies with glycoconjugates Valuation and commercialisation, pending challenges<\/p>\n","protected":false},"author":6,"featured_media":7745,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"default","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[305],"tags":[],"class_list":["post-5487","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innovation"],"publishpress_future_action":{"enabled":false,"date":"2024-12-30 03:34:24","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category"},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts\/5487","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/comments?post=5487"}],"version-history":[{"count":0,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/posts\/5487\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media\/7745"}],"wp:attachment":[{"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/media?parent=5487"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/categories?post=5487"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/idibell.cat\/en\/wp-json\/wp\/v2\/tags?post=5487"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}